Non-Destructive Raman Spectroscopic Method for Estimation of Montelukast From Tablet Dosages Form

Abstract

Objective: A rapid, non-destructive and non-solvent raman spectroscopic method for estimation of Montelukast from tablet dosages form Methods: Quantification was carried out by measuring the intensity of analyte peak at 1440 cm -1 . Each Raman spectrum corresponded to an accumulation of 4 scans with an exposure time of 5 sec for each scan with a total integration time of 20 sec. Results:The method exhibited linearity between 2 mg-24 mg show well resolve quantification From MON. The linearity equation was calculated as y = 13.036x+70.819 and the correlation coefficient was found to be 0.997 for MON. LOD (limit of detection) and LOQ(limit of quantification) values were calculated using the calibration curve slope and standard deviation of the response. The LOD (limit of detection) and LOQ (limit of quantification) values were found to be 1.71 mg and 5.13 mg respectively. Conclusion:The developed method was successfully applied for assay of montelukast in the intact formulation. The method was validated according to an international conference on harmonisation guidelines. A recent study, montelukast sodium had been analysed by the raman method, but, looking into the tremendous potential of raman spectroscopic method; it can be extended as a process analysis and technology tool in various quality checks during manufacturing of pharmaceutical products.

Non-Destructive Analysis of Chlorpheniramine Maleate Tablets and Granules by Chemometrics-Assisted Attenuated Total Reflectance Infrared Spectroscopy

“…Applications for non-destructive analysis based on chemometrics-assisted spectroscopic methods such as near-infrared (NIR) spectroscopy, Raman spectroscopy, Terahertz spectroscopy, Fourier transform infrared spectroscopy (FTIR) for process analytical technology (PAT), and quality control in pharmaceutical manufacturing are increasing [2][3][4][5][6][7][8]. In addition, trend quality guidelines for regulation use chemometrics-assisted spectroscopic methods in drug quality control [9].…”