Non Diabetic and Stress Induced Hyperglycemia [SIH] in Orthopaedic Practice What do we know so Far?

Goyal, Navendu; Kaur, Randeep; Sud, Ambuj; Ghorpade, Nilesh; Gupta, Manu

doi:10.7860/jcdr/2014/10027.5022

Cited by 7 publications

(6 citation statements)

References 26 publications

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“…There is also evidence that acute hyperglycemia is more detrimental than chronic hyperglycemia. This finding has been demonstrated in other inpatient populations [13][14][15][16][17]. In addition to poor short-term outcomes, patients with hyperglycemia in the setting of acute stroke may have worse longterm outcomes.…”

Section: Discussionsupporting

confidence: 59%

Inpatient Glycemic Management of Non-cardiac CVD: Focus on Stroke and PVD

Everett

Mathioudakis

2018

Curr Diab Rep

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Hyperglycemia in acute stroke is associated with poor short and long-term outcomes, and perioperative hyperglycemia in those undergoing revascularization for PVD is linked to increased post-surgical complications. Studies evaluating tight glucose control do not demonstrate improvement in clinical outcomes, although the risk for hypoglycemia increases substantially. Additional studies are needed to evaluate tight glucose goals relative to our current standard of care and the role of permissive hyperglycemia. Given the limited data to guide glycemic management in these patient populations, it is recommended that general guidelines for inpatient glycemic control be followed. Special considerations should be made to address factors that may impact glucose management, including neurological deficits and clinical changes that occur in the postoperative state.

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Section: Discussionsupporting

confidence: 59%

Inpatient Glycemic Management of Non-cardiac CVD: Focus on Stroke and PVD

Everett

Mathioudakis

2018

Curr Diab Rep

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“…38 Several other authors have noted that hyperglycemia in patients without a history or diagnosis of diabetes may be due to undiagnosed diabetes or as a result of stress-induced hyperglycemia. 14,26,39,40 Moreover, there is evidence in the orthopaedic trauma literature to suggest that hyperglycemia in the absence of an elevated hemoglobin A1C level is significantly associated with SSI. 26 Although there is no consensus definition, stress hyperglycemia is believed to be an acute physiologic process because of hormone and cytokine release in response to stress.…”

Section: Discussionmentioning

confidence: 99%

Admission Hyperglycemia Is a Risk Factor for Deep Surgical-Site Infection in Orthopaedic Trauma Patients

Anderson

Wise²,

Joshi

et al. 2021

Journal of Orthopaedic Trauma

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orthopaedic trauma patients with an extremity, pelvic, or acetabular fracture and requiring open reduction and internal fixation or intramedullary nailing. Intervention: None. Main Outcome Measurements: Ninety-day deep surgical site infection.Results: Admission blood glucose $200 mg/dL was significantly associated with the primary outcome (8/128, 6.3% vs. 35/337, 1.8%; P = 0.01). Multivariable logistic regression modeling demonstrated that admission blood glucose $200 mg/dL was a significant risk factor for deep surgical site infections [odds ratio (OR): 4.7, 95% confidence interval (CI) 1.4-15.7], after controlling for male gender

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“…), all the original details can be seen in references that follows [14] [15] [16]. It can be speculated that all kinds of stressors to the brain, in a "always present way", can indeed cause persistent hyperglycemia, a typical example of a noxious external element is the persistent mental stress induced by stressful work which might cause the well-known "burnout" or chronic fatigue syndrome (CFS) ("exhaustion syndrome") [17] [18] [19] [20].…”

Section: Introductionmentioning

confidence: 99%

Can Persistent Children Hyperglycemia Be Induced by Causes Other Than Pancreas Failure?

Assis¹,

Nobrega²

2022

OJEMD

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In this work, children's persistent hyperglycemia has been revised using the available literature to support the proposed reasoning. Based on this study, we have shown that the human glycemic management system must be seen as coupled and integrated by four subsystems, namely, production system, consumption system, distribution system, control system, and also it should be seen as coupled to external noxious factors/stressors, if not we show that the glycemic homeostasis analysis might be defective and might induce, in many cases, a misdiagnosis of the causes of the persistent hyperglycemia under consideration. Also, in this work, some considerations were presented to show that anomalies in the cerebral glycemic control through the glucose sensor neurons might be a possible cause/origin of some of the glycemic abnormalities and dysfunctions (however, not only the known related hypoglycemia but also hyperglycemia) that occur in childhood. Finally, it is shown that persistent novel external noxious factors of modernity or noxious factors already known, but amplified by modernity, such as persistent stress, media induced fears, and phobias, environmental pollution, and electromagnetic pollution, can and should also be considered as possible precursors for the development of anomalies in the juvenile homeostatic glycemic system that might well be, if intense and persistent, the driver of the worldwide observed T1DM epidemic events.

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Non Diabetic and Stress Induced Hyperglycemia [SIH] in Orthopaedic Practice What do we know so Far?

Cited by 7 publications

References 26 publications

Inpatient Glycemic Management of Non-cardiac CVD: Focus on Stroke and PVD

Inpatient Glycemic Management of Non-cardiac CVD: Focus on Stroke and PVD

Admission Hyperglycemia Is a Risk Factor for Deep Surgical-Site Infection in Orthopaedic Trauma Patients

Can Persistent Children Hyperglycemia Be Induced by Causes Other Than Pancreas Failure?

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