Non-dopaminergic neurons partly expressing dopaminergic phenotype: Distribution in the brain, development and functional significance

Ugrumov, M. V.

doi:10.1016/j.jchemneu.2009.08.004

Cited by 97 publications

(118 citation statements)

References 84 publications

(209 reference statements)

Supporting

Mentioning

114

Contrasting

Unclassified

Order By: Relevance

“…Our observations are consistent with the results of recent studies, obtained by Ugrumov on fetus of mammals in natal and early postnatal periods of development prior to the formation of the blood-brain barrier (BBB) [23,24]. Undifferentiated neurons of rat's hypothalamus in these periods of fetal development have not formed synaptic structure yet and cells expressed a number of specific syntheses, including TH.…”

Section: Discussionsupporting

confidence: 92%

“…Inhibitory influence of serotonin to gene expression of neuropeptides was established, but serotonin also has a stimulating effect on the expression of the enzyme of monoamine synthesis [25]. Since this period of development in mammals the BBB has not yet formed, it prevents inflow of the substances to the systemic circulation, and thus cells act as endocrine glands, and brain act as an endocrine organ [23,24]. Evidence of this hypothesis is the establishment that concentration signals of cerebral origin in the blood in fetuses and newborn rats are as high as in the portal blood of adult animal.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Undifferentiated Catecholaminergic and NO-Producing Cells of Forebrain Matrix Zones and Intercellular Relationships in Periventricular Diencephalon of Juvenile Oncorhynchus masou

Пущина¹

2015

AJBIO

View full text Add to dashboard Cite

Localization of TH-and NO-producing systems in the diencephalon of juvenile masu salmon Oncorhynchus masou was investigated by using histofluorescence labeling of glyoxylic acid (GA), and ICH labeling of tyrosine hydroxylase (TH) and neuronal nitric oxide synthase (nNOS). High density distribution of catecholaminergic and NO-ergic cells has been found in preoptic, posterior tuberal and hypothalamic areas. Cells revealed in above mentioned diencephalic areas were assigned to three main types: pear-shaped, bipolar and rounded. Most of the TH-and NO-producing cells had the phenotype of undifferentiated elements localized on territory of diencephalic matrix zones. Paracrine and autocrine relationships between TH-and NO-producing cells in periventricular diencephalon of juvenile O. masou before formation of blood-brain barrier have been hypothesized. The lack of differentiated cells and the presence of a large variety of size groups of cells indicate a possible heterochrony in growth and differentiation of O. masou diencephalic areas. Location of catecholaminergic and NO-producing cells in the territory of diencephalic matrix zones suggests that catecholamines and nitric oxide are involved in the regulation of post-embryonic neurogenesis in diencephalon of O. masou.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Undifferentiated Catecholaminergic and NO-Producing Cells of Forebrain Matrix Zones and Intercellular Relationships in Periventricular Diencephalon of Juvenile Oncorhynchus masou

Пущина¹

2015

AJBIO

View full text Add to dashboard Cite

show abstract

“…The AN is a DA center at the hypothalamus-hypophyseal axis with the peculiarity of having dissociated the synthesis of DA. A significant number of AN neurons produce only one of the enzymes required for DA synthesis (Ugrumov 2009), being the production of DA, a cooperative task involving several neuronal subpopulations. The neurochemical and histological alterations in GDNF-deprived mice leads to the development of behavioral motor abnormalities characterized by a progressive hypokinetic syndrome (Fig.…”

Section: ;mentioning

confidence: 99%

GDNF and protection of adult central catecholaminergic neurons

Pascual

Hidalgo-Figueroa²,

Gómez-Díaz³

et al. 2011

Journal of Molecular Endocrinology

View full text Add to dashboard Cite

Neurotrophic factors are small proteins necessary for neuron survival and maintenance of phenotype. They are considered as promising therapeutic tools for neurodegenerative diseases. The glial cell line-derived neurotrophic factor (GDNF) protects catecholaminergic cells from toxic insults; thus, its potential therapeutic applicability in Parkinson's disease has been intensely investigated. In recent years, there have been major advances in the analysis of GDNF signaling pathways in peripheral neurons and embryonic dopamine mesencephalic cells. However, the actual physiological role of GDNF in maintaining catecholaminergic central neurons during adulthood is only starting to be unraveled, and the mechanisms whereby GDNF protects central brain neurons are poorly known. In this study, we review the current knowledge of GDNF expression, signaling, and function in adult brain, with special emphasis on the genetic animal models with deficiency in the GDNF-dependent pathways.

show abstract

“…Demonstrating the presence of L -amino acid decarboxylase and DA itself in these cells will be necessary to confirm this. If L -amino acid decarboxylase and/ or DA are not found in these cells, they would instead be similar to the hundreds of non-DAergic TH-ir cells in the rat, hamster, mouse, guinea pig, monkey and human brain that have been previously described [reviewed in Ugrumov, 2009]. In fact, fewer than 25% of the TH-ir cells in the male Syrian hamster amygdala can be confirmed to be DAergic [Asmus et al, 1992] and the same could be true in male prairie voles.…”

Section: Implications Of a Species-specific Th-ir Networkmentioning

confidence: 99%

Neuroanatomical Projections of the Species-Specific Tyrosine Hydroxylase-Immunoreactive Cells of the Male Prairie Vole Bed Nucleus of the Stria Terminalis and Medial Amygdala

Northcutt¹,

Lonstein²

2011

Brain Behav Evol

View full text Add to dashboard Cite

The principal nucleus of the bed nucleus of the stria terminalis (BSTpr) and posterodorsal part of the medial amygdalar nucleus (MEApd) are densely interconnected sites transmitting olfactory information to brain areas mediating sociosexual behaviors. In male prairie voles (Microtus ochrogaster), the BSTpr and MEApd contain hundreds of cells densely immunoreactive for tyrosine hydroxylase (TH). Such tremendous numbers of TH-immunoreactive (TH-ir) cells do not exist in other rodents examined, and studies from our laboratory suggest these cells may be part of a unique chemical network necessary for monogamous behaviors in prairie voles. To obtain information about how these TH-ir cells communicate with other sites involved in social behaviors, we first used biotinylated dextran amine (BDA) to determine sites that receive BSTpr efferents and also contain TH-ir fibers. Only in the medial preoptic area (MPO) and MEApd did we find considerable comingling of BDA-containing and TH-ir fibers. To examine if these sites receive input specifically from BSTpr TH-ir cells, the retrograde tracer Fluorogold was infused into the MPO or MEApd. Almost 80% of TH-ir projections to the MPO originated from the BSTpr or MEApd, involving about 40% of all TH-ir cells in these sites. In contrast, the MEApd received almost no input from TH-ir cells in the BSTpr, and received it primarily from the ventral tegmental area. Retrograde tracing from the BSTpr itself revealed substantial input from MEApd TH-ir cells. Thus, the male prairie vole brain contains a species-specific TH-ir network involving the BSTpr, MEApd, and MPO. By connecting brain sites involved in olfaction, sociality and motivation, this network may be essential for monogamous behaviors in this species.

show abstract

Non-dopaminergic neurons partly expressing dopaminergic phenotype: Distribution in the brain, development and functional significance

Cited by 97 publications

References 84 publications

Undifferentiated Catecholaminergic and NO-Producing Cells of Forebrain Matrix Zones and Intercellular Relationships in Periventricular Diencephalon of Juvenile Oncorhynchus masou

Undifferentiated Catecholaminergic and NO-Producing Cells of Forebrain Matrix Zones and Intercellular Relationships in Periventricular Diencephalon of Juvenile Oncorhynchus masou

GDNF and protection of adult central catecholaminergic neurons

Neuroanatomical Projections of the Species-Specific Tyrosine Hydroxylase-Immunoreactive Cells of the Male Prairie Vole Bed Nucleus of the Stria Terminalis and Medial Amygdala

Contact Info

Product

Resources

About