Non enzymatic colorimetric detection of glucose using cyanophenyl boronic acid included β-cyclodextrin stabilized gold nanoparticles

Nair, Priya A.; Sreenivasan, K.

doi:10.1039/c5ay02716k

Cited by 29 publications

(13 citation statements)

References 29 publications

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“…Nevertheless, the sensitive enzymatic glucose sensors are associated with several drawbacks such as instability (pH, temperature and humidity) due to the denaturation of the enzyme, oxygen limitations and complex immobilization procedures [ 12 ]. Owing to the fast growth of the world population, ~422 million people in 2020 suffered from diabetes, and the number is expected to reach 592 million by 2035 [ 13 ]. Therefore, the development of an accurate, sensitive and low-cost electrochemical glucose sensor is of great need.…”

Section: Introductionmentioning

confidence: 99%

Sensitive Electrochemical Non-Enzymatic Detection of Glucose Based on Wireless Data Transmission

Kim

Chinnadayyala

et al. 2022

Sensors

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Miniaturization and wireless continuous glucose monitoring are key factors for the successful management of diabetes. Electrochemical sensors are very versatile and can be easily miniaturized for wireless glucose monitoring. The authors report a microneedle-based enzyme-free electrochemical wireless sensor for painless and continuous glucose monitoring. The microneedles (MNs) fabricated consist of a 3 × 5 sharp and stainless-steel electrode array configuration. Each MN in the 3 × 5 array has 575 µm × 150 µm in height and width, respectively. A glucose-catalyzing layer, porous platinum black, was electrochemically deposited on the tips of the MNs by applying a fixed cathodic current of 2.5 mA cm−2 for a period of 200 s. For the non-interference glucose sensing, the platinum (Pt)-black-coated MN was carefully packaged into a biocompatible ionomer, nafion. The surface morphologies of the bare and modified MNs were studied using field-emission scanning electron microscopy (FESEM) and energy-dispersive X-ray analysis (EDX). The wireless glucose sensor displayed a broad linear range of glucose (1→30 mM), a good sensitivity and higher detection limit of 145.33 μA mM−1 cm−2 and 480 μM, respectively, with bare AuMN as a counter electrode. However, the wireless device showed an improved sensitivity and enhanced detection limit of 445.75, 165.83 μA mM−1 cm−2 and 268 μM, respectively, with the Pt-black-modified MN as a counter electrode. The sensor also exhibited a very good response time (2 s) and a limited interference effect on the detection of glucose in the presence of other electroactive oxidizing species, indicating a very fast and interference-free chronoamperometric response.

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Section: Introductionmentioning

confidence: 99%

Sensitive Electrochemical Non-Enzymatic Detection of Glucose Based on Wireless Data Transmission

Kim

Chinnadayyala

et al. 2022

Sensors

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“…The use of in-situ synthesis of nanomaterials for colorimetric sensing has gained much attention due to its simplicity, ease of operation, and good sensitivity [ 21 ]. Some optical, colorimetric glucose sensing mechanisms based on noble metal nanoparticles have been presented in the literature, but most rely on pre-functionalization of particles or complementary use of enzymes or other catalytic reactions for the production of color signals, instead of using direct reactions between glucose and the precursor reagents, and there is yet to be such approach translated into a paper-based platform [ 22 , 23 , 24 , 25 , 26 , 27 ]. Nanostructured gold has also been applied in electrochemical sensing as a means of improving sensors catalytic capabilities, both in conjugation with GOx or for the development of non-enzymatic sensors [ 28 , 29 , 30 , 31 , 32 ].…”

Section: Introductionmentioning

confidence: 99%

Paper-Based In-Situ Gold Nanoparticle Synthesis for Colorimetric, Non-Enzymatic Glucose Level Determination

et al. 2020

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Due to its properties, paper represents an alternative to perform point-of-care tests for colorimetric determination of glucose levels, providing simple, rapid, and inexpensive means of diagnosis. In this work, we report the development of a novel, rapid, disposable, inexpensive, enzyme-free, and colorimetric paper-based assay for glucose level determination. This sensing strategy is based on the synthesis of gold nanoparticles (AuNPs) by reduction of a gold salt precursor, in which glucose acts simultaneously as reducing and capping agent. This leads to a direct measurement of glucose without any enzymes or depending on the detection of intermediate products as in conventional enzymatic colorimetric methods. Firstly, we modelled the synthesis reaction of AuNPs to determine the optical, morphological, and kinetic properties and their manipulation for glucose sensing, by determining the influence of each of the reaction precursors towards the produced AuNPs, providing a guide for the manipulation of nucleation and growth. The adaptation of this synthesis into the developed paper platform was tested and calibrated using different standard solutions with physiological concentrations of glucose. The response of the colorimetric signals obtained with this paper-based platform showed a linear behavior until 20 mM, required for glycemic control in diabetes, using the Red × Value/Grey feature combination as a calibration metric, to describe the variations in color intensity and hue in the spot test zone. The colorimetric sensor revealed a detection limit of 0.65 mM, depending on calibration metric and sensitivity of 0.013 AU/mM for a linear sensitivity range from 1.25 to 20 mM, with high specificity for the determination of glucose in complex standards with other common reducing interferents and human serum.

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“…Numerous studies employing nanomaterials, such as nAg, nAu, carbon dots, carbon nanotubes, and quantum dots, have been reported for detection of biomarkers in the diagnosis and monitoring of diseases using cost-effective methodologies. In this context, a nonenzymatic colorimetric detection of glucose based on the inclusion of 4-cyanophenyl boronic acid (CPBA) with β-cyclodextrin stabilized nAu was developed for potential use in the management of diabetes . Results showed that the engineered nanoprobes possessed good solubility and exhibited good selectivity for glucose in aqueous media .…”

Section: Engineering Biomedical Devices For Potential Applicationsmentioning

confidence: 99%

“…In this context, a nonenzymatic colorimetric detection of glucose based on the inclusion of 4-cyanophenyl boronic acid (CPBA) with β-cyclodextrin stabilized nAu was developed for potential use in the management of diabetes . Results showed that the engineered nanoprobes possessed good solubility and exhibited good selectivity for glucose in aqueous media . Furthermore, the applicability of this method was validated using human blood serum samples which demonstrated that the developed methodology could detect glucose in the concentration range between 1–20 mM and hence can be exploited for detection of glucose in biological fluids .…”

Section: Engineering Biomedical Devices For Potential Applicationsmentioning

confidence: 99%

Recent Advances in Biomaterials Science and Engineering Research in India: A Minireview

Victor

Selvam

Sharma

2018

ACS Biomater. Sci. Eng.

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Biomedical research in health innovation and product development encompasses convergent technologies that primarily integrate biomaterials science and engineering at its core. Particularly, research in this area is instrumental for the implementation of biomedical devices (BMDs) that offer innovative solutions to help maintain and improve quality of life of patients worldwide. Despite achieving extraordinary success, implantable BMDs are still confronted with complex engineering and biological challenges that need to addressed for augmenting device performance and prolonging lifetime in vivo. Biofabrication of tissue constructs, designing novel biomaterials and employing rational biomaterial design approaches, surface engineering of implants, point of care diagnostics and micro/nano-based biosensors, smart drug delivery systems, and noninvasive imaging methodologies are among strategies exploited for improving clinical performance of implantable BMDs. In India, advances in biomedical technologies have dramatically advanced health care over the last few decades and the country is well-positioned to identify opportunities and translate emerging solutions. In this article, we attempt to capture the recent advances in biomedical research and development progressing across the country and highlight the significant research work accomplished in the areas of biomaterials science and engineering.

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Non enzymatic colorimetric detection of glucose using cyanophenyl boronic acid included β-cyclodextrin stabilized gold nanoparticles

Abstract: Gold nanoparticles generated and stabilized by a β-cyclodextrin–cyano phenyl boronic acid complex enable the colorimetric detection of glucose.

Cited by 29 publications

References 29 publications

Sensitive Electrochemical Non-Enzymatic Detection of Glucose Based on Wireless Data Transmission

Sensitive Electrochemical Non-Enzymatic Detection of Glucose Based on Wireless Data Transmission

Paper-Based In-Situ Gold Nanoparticle Synthesis for Colorimetric, Non-Enzymatic Glucose Level Determination

Recent Advances in Biomaterials Science and Engineering Research in India: A Minireview

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