Non-Functional Carotid Body Tumors in Patients Without Somatic Mutations May Be Considered for Non-Operative Management

Malignant carotid body tumors: What we know, what we do, and what we need to achieve. A systematic review of the literature

“…Detailed scores according to the JBI checklist 153 for each article considered in the pooled MA are reported in Table S2. All included manuscripts were retrospective case series 18–39 ; of these 3 (15%) were multicentric 18,31,39 …”

“…Finally, 132 papers were considered appropriate for the present SR, for a total of 337 patients (Figure 1). Among these articles, 20 (158 patients) included 5 or more patients (Table 1) 18–39 and were considered for the proportion MA. The remaining 112 studies (179 patients), represented by case reports or case series with <5 patients, are reported in Table S1 3,40–152 …”

“…For proportion meta‐analysis (MA), only case series with at least five consecutive cases were considered (Table 1). 18–39 All the other case series describing less than five patients (including case reports) were considered only for the SR and detailed in Table S1 3,40–152 …”

“…Bilaterality is also more frequently associated with malignant behavior (25% for MCBTs compared with 8.5% for benign CBTs in the Zhang series). 36 Biochemical activity was rarely described, even though it reached 20% in the series by Reitz et al, 39 thus roughly paralleling the rate of familial syndromes.…”

“…All included manuscripts were retrospective case series ; of these 3 (15%) were multicentric. 18,31,39…”