Non-HDL-cholesterol/HDL-cholesterol is a better predictor of metabolic syndrome and insulin resistance than apolipoprotein B/apolipoprotein A1

Kim, Se Won; Jee, Jae Hwan; Kim, Hye Jeong; Jin, Sang‐Man; Suh, Sunghwan; Bae, Ji Cheol; Kim, Sun Wook; Chung, Jae Hoon; Min, Yong‐Ki; Lee, Myung-Shik; Lee, Moon‐Kyu; Kim, Kwang-Won; Kim, Jae Hyun

doi:10.1016/j.ijcard.2013.03.027

Cited by 118 publications

(100 citation statements)

References 37 publications

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“…We demonstrated that non-HDL cholesterol (including Diff-C fraction) is strongly associated with metabolic syndrome. It was a consistent finding after multiple adjustments, in line with the majority of previous studies [22–26]. …”

Section: Discussionsupporting

confidence: 91%

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Non–high-density lipoprotein fractions are strongly associated with the presence of metabolic syndrome independent of obesity and diabetes: a population-based study among Iranian adults

Ghodsi

Meysamie

Abbasi

et al. 2017

J Diabetes Metab Disord

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BackgroundNon-HDL-C as a valuable predictor of premature atherosclerosis, coronary events like first Myocardial infarction and cardiovascular mortality has a high accuracy of measurement both in fasting and non-fasting individuals. Metabolic syndrome (MetS) can promote the development of diabetes mellitus, endothelial dysfunction and atherosclerosis. A common pathway for cross linking of metabolic abnormalities and non-HDL-C has been suggested. In this study we aimed to describe the potential association between non-HDL cholesterol fractions and metabolic syndrome.MethodsData of third national surveillance of the risk factors of non-communicable diseases (SuRFNCD-2007) were analyzed. We defined metabolic syndrome (MetS) according to the Adult Treatment Panel III (ATPIII) and International Diabetes Federation (IDF) criteria for 2125 subjects aging 25–64 years. The receiver operating characteristic (ROC) curves were used to determine the optimal cut-points for the diagnosis of MetS. The curves were depicted for non–high-density lipoprotein cholesterol (non-HDL-C) and difference of total non-HDL-C and LDL-C (Differential cholesterol or Diff-C) as predictors of MetS. Logistic regression was also performed in a complex sample analysis scheme.ResultsThe area under the curve (AUC) with 95% Confidence intervals of total non-HDL-C was computed. Values were 0.693 (0.670-0.715) for IDF-defined MetS and 0.719 (0.697-0.740) for ATPIII criteria. The optimal non-HDL-C cut-point we recommend for both criteria is 153.50 mg/dl (sensitivity: 75.7%, specificity: 57.2%, with ATPIII; sensitivity: 73.2%, specificity: 57.1%, with IDF). Using IDF criteria, the accuracy of predictors were greater in non-diabetic subjects. AUC of Diff-C in DM (−) vs. DM (+) were 0.786 (0.765-0.807) vs. 0.627(0.549-0.705). Adults with high non–HDL-C were 4.42 times more likely to have ATPIII-defined MetS (≥190 vs. < 190 mg/dL). Elevated Diff-C corresponded to increased risk of the MetS (ORs: 10.71 and 26.29 for IDF and ATP III criteria, respectively. All P-values <0.001).ConclusionsA significant robust association exists between non-HDL-C and MetS whether applying conventional or new thresholds.

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Section: Discussionsupporting

confidence: 91%

“…Plasma concentrations of the lipoproteins were highly related to the number of MetS components which was similar to results of previous studies [22–24]. The prevalence of MetS increased to a large degree along with rising levels of total non-HDL-C and Diff-C fractions regardless of gender type or criteria set for MetS.…”

Section: Discussionsupporting

confidence: 88%

Non–high-density lipoprotein fractions are strongly associated with the presence of metabolic syndrome independent of obesity and diabetes: a population-based study among Iranian adults

Ghodsi

Meysamie

Abbasi

et al. 2017

J Diabetes Metab Disord

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“…The NonHDLc/HDLc ratio captures atherogenic lipid abnormalities other than LDLc including abnormalities in lipid particles such as small dense LDL, very low-density lipoproteins (VLDL), and HDLc similarly to that of ApoB/A1 [9]. Accordingly, the NonHDLc/HDLc ratio had a stronger association with CHD risk than LDLc, HDL-cholesterol or non-HDL-cholesterol [11,20,21]. Our research described here extends findings that the NonHDLc/HDLc ratio not only is associated with CHD but also with the development of CKD.…”

Section: Discussionmentioning

confidence: 99%

“…identifying metabolic syndrome and insulin resistance [11]. Although sharing similar risk factors with CHD, little is known about the association between the NonHDLc/HDLc ratio and CKD.…”

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 99%

Non-HDL-cholesterol to HDL-cholesterol ratio as an independent risk factor for the development of chronic kidney disease

Zuo¹,

Chen²,

Liu

et al. 2015

Nutrition, Metabolism and Cardiovascular Diseases

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“…The LDLC:HDLC ratio can predict CHD development with higher hazard ratio than LDLC and HDLC levels and has been found to be an independent predictor for acute myocardial infarction in the Japanese population [4,7]. The non-HDLC:HDLC ratio is also suggested to be a better predictor of CHD risk than LDLC levels in a follow-up study for a mean of 4.8 years in the Swedish National Diabetes Register and has been found to be a stronger marker of metabolic syndrome and insulin resistance in Korean adults than apolipoprotein B/apolipoprotein A1 [8,9]. …”

Section: Introductionmentioning

confidence: 99%

Genome-Wide Association Study Reveals Four Loci for Lipid Ratios in the Korean Population and the Constitutional Subgroup

et al. 2017

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Circulating lipid ratios are considered predictors of cardiovascular risks and metabolic syndrome, which cause coronary heart diseases. One constitutional type of Korean medicine prone to weight accumulation, the Tae-Eum type, predisposes the consumers to metabolic syndrome, hypertension, diabetes mellitus, etc. Here, we aimed to identify genetic variants for lipid ratios using a genome-wide association study (GWAS) and followed replication analysis in Koreans and constitutional subgroups. GWASs in 5,292 individuals of the Korean Genome and Epidemiology Study and replication analyses in 2,567 subjects of the Korea medicine Data Center were performed to identify genetic variants associated with triglyceride (TG) to HDL cholesterol (HDLC), LDL cholesterol (LDLC) to HDLC, and non-HDLC to HDLC ratios. For subgroup analysis, a computer-based constitution analysis tool was used to categorize the constitutional types of the subjects. In the discovery stage, seven variants in four loci, three variants in three loci, and two variants in one locus were associated with the ratios of log-transformed TG:HDLC (log[TG]:HDLC), LDLC:HDLC, and non-HDLC:HDLC, respectively. The associations of the GWAS variants with lipid ratios were replicated in the validation stage: for the log[TG]:HDLC ratio, rs6589566 near APOA5 and rs4244457 and rs6586891 near LPL; for the LDLC:HDLC ratio, rs4420638 near APOC1 and rs17445774 near C2orf47; and for the non-HDLC:HDLC ratio, rs6589566 near APOA5. Five of these six variants are known to be associated with TG, LDLC, and/or HDLC, but rs17445774 was newly identified to be involved in lipid level changes in this study. Constitutional subgroup analysis revealed effects of variants associated with log[TG]:HDLC and non-HDLC:HDLC ratios in both the Tae-Eum and non-Tae-Eum types, whereas the effect of the LDLC:HDLC ratio-associated variants remained only in the Tae-Eum type. In conclusion, we identified three log[TG]:HDLC ratio-associated variants, two LDLC:HDLC ratio-associated variants, and one non-HDLC:HDLC-associated variant in Koreans and the constitutional subgroups.

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Non-HDL-cholesterol/HDL-cholesterol is a better predictor of metabolic syndrome and insulin resistance than apolipoprotein B/apolipoprotein A1

Cited by 118 publications

References 37 publications

Non–high-density lipoprotein fractions are strongly associated with the presence of metabolic syndrome independent of obesity and diabetes: a population-based study among Iranian adults

Non–high-density lipoprotein fractions are strongly associated with the presence of metabolic syndrome independent of obesity and diabetes: a population-based study among Iranian adults

Non-HDL-cholesterol to HDL-cholesterol ratio as an independent risk factor for the development of chronic kidney disease

Genome-Wide Association Study Reveals Four Loci for Lipid Ratios in the Korean Population and the Constitutional Subgroup

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