Non-HDL cholesterol is better than Friedewald-estimated LDL cholesterol to associate with cardiometabolic markers

Abstract

Background and aim: Recent research has shown that non high-density lipoprotein cholesterol (non-HDL-C), a lipid measure that includes cholesterol of all potentially atherogenic lipoproteins, is a useful marker of the risk of cardiovascular disease. On the other hand, associations of non-HDL-C with dyslipidemia and metabolic syndrome (MetS) in healthy general population appear to be of importance in primary prevention and management of diseases. We here aim to analyze the correlation of non-HDL-C and Friedewald-estimated low density lipoprotein-cholesterol (LDL-C) with several routine metrics including body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting plasma glucose, hemoglobin A 1c (HbA 1c ), triglyceride, and uric acid for a healthy adult population in Japan.

Lactobacillus Strains Alleviated Hyperlipidemia and Liver Steatosis in Aging Rats via Activation of AMPK

“…Reports are now showing that cardiac events occur in people even without clinically abnormal LDL-C concentrations, suggesting that LDL-C is not the only parameter that need to be monitored [2]. Suggestion to improve the risk prediction and treatment has been to focus on non-high-density-lipoprotein (HDL) cholesterol (includes LDL and other intermediate or end products of triglyceride-rich lipoprotein) levels rather than on just LDL-C [8]. Probiotics, such as those from the genus of Lactobacillus, have been reported to have a long history of safe use, primarily for gut health, antimicrobial properties [9,10], and now in metabolic diseases including hypertension [11] for improvement of blood lipid profiles and reducing total cholesterol (TC) and TG concentrations in blood [12,13].…”

C-reactive Protein Associates with Metabolic Syndrome: An Improved Conventional Assay may Fit for Purpose in Population-based Analyses

“…For measurement CRP levels, CRP-latex Seiken was used (DENKA SEIKEN Co., Ltd, Tokyo, Japan). The measurements of other parameters were done as we previously described [11][12][13]. Briefly, for triglyceride (TG), total cholesterol (T-Chol), and HDL-cholesterol (HDL-Chol) levels, a Toshiba TBA-40FR Autoanalyzer (Toshiba Medical Systems, Tokyo, Japan) was used.…”