Non‐heartbeating kidney donors

Laskowski, Igor; Pratschke, Johann; Wilhelm, Markus J.; Paz, Dustin; Tilney, Nicholas L.

doi:10.1034/j.1399-0012.1999.130401.x

Cited by 16 publications

(6 citation statements)

References 23 publications

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“…A number of legal, ethical and logistic reasons as well as medical concerns are responsible for this and have even compromised existing NHBD programs50.…”

Section: Discussionmentioning

confidence: 99%

Non Heart-Beating Donors in England

Chaib

2008

Clinics

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Chaib E. Non heart-beating-donors in England. Clinics. 2008;63(1):121-34. When transplantation started all organs were retrieved from patients immediately after cardio-respiratory arrest, i.e. from nonheart-beating donors. After the recognition that death resulted from irreversible damage to the brainstem, organ retrieval rapidly switched to patients certified dead after brainstem testing. These heart-beating-donors have become the principal source of organs for transplantation for the last 30 years. The number of heart-beating-donors are declining and this is likely to continue, therefore cadaveric organs from non-heart-beating donor offers a large potential of resources for organ transplantation. The aim of this study is to examine clinical outcomes of non-heart-beating donors in the past 10 years in the UK as an way of decreasing pressure in the huge waiting list for organs transplantation. KEYWORDS:Transplantation. Liver. Kidney. Donors.The imbalance between supply of organs for transplantation and demand for them is widening all over the world. In the United Kingdom (UK) the figures are not different, by the end of December 2004 there were over 6000 people on the active waiting list for organ transplantation. Recent data suggest that over 400 of these people will die each year before a new organ becomes available.

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“…A number of legal, ethical and logistic reasons as well as medical concerns are responsible for this and have even compromised existing NHBD programs50.…”

Section: Discussionmentioning

confidence: 99%

Non Heart-Beating Donors in England

Chaib

2008

Clinics

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“…Nonheart-beating donors programs remain unpopular despite the potential to increase the donor pool by up to 30% [5]. A number of legal, ethical and logistic reasons as well as medical concerns are responsible for this and have even compromised existing NHBD programs [6].…”

Section: Discussionmentioning

confidence: 99%

Expected number of deaths in the liver transplantation waiting list in the state of São Paulo, Brazil

Chaib¹,

Massad²

2008

Transplant Int

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“…It is well known that donor age and organ quality strongly affect the outcome in renal transplantation [15]. One hypothesis suggests that the cumulative burden of age-related changes, immunologic and nonimmunologic injuries, accelerate the process of cell senescence and exhaust their ability to repair the damage [16].…”

Section: Figurementioning

confidence: 99%

Chronic Rejection of Small Bowel Grafts: Pediatric and Adult Study of Risk Factors and Morphologic Progression

et al. 2003

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One hundred and seventy-two patients underwent small bowel transplantation at Children's Hospital of Pittsburgh and University of Pittsburgh Medical Center between May 1990 and August 2001. Thirty-four patients had complete or partial resection of their primary graft and in 15, histologic features of chronic rejection were present in the resected small bowel. This is a descriptive and correlative study of the demographic, perioperative, and histologic features associated with progression to intestinal graft failure. Variable features associated with an increased risk of chronic rejection included acute rejection within the 1st month, increased number and higher grade of acute rejection episodes, isolated small bowel grafts rather than small bowel-liver grafts, older recipient age, non-Caucasian race, and Caucasian to non-Caucasian transplant. The mucosal biopsies showed predictive changes many months before the grafts were excised. The mucosal biopsy diagnosis of chronic vascular rejection can be difficult because the affected vessels, the distal branches of the mesenteric arteries, and the larger arteries of the subserosa and submucosa are not routinely sampled. The possibility of underlying arteriopathy, however, can be inferred in some instances from the presence of secondary mucosal changes in the small bowel biopsies though the "early" changes lack specificity. It is the progression of biopsy findings over time that is predictive of outcome. It is important to recognize the persistence of "late" mucosal changes of chronic rejection so that patients are not subjected to increased immune suppression when it is unlikely to be of significant benefit.

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Non‐heartbeating kidney donors

Cited by 16 publications

References 23 publications

Non Heart-Beating Donors in England

Non Heart-Beating Donors in England

Expected number of deaths in the liver transplantation waiting list in the state of São Paulo, Brazil

Chronic Rejection of Small Bowel Grafts: Pediatric and Adult Study of Risk Factors and Morphologic Progression

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