Non–high-density lipoprotein cholesterol and other lipid indices vs elevated glucose risk in Arab adolescents

Al-Daghri, Nasser M.; Aljohani, Naji; Al‐Attas, Omar S.; Al‐Saleh, Yousef; Wani, Kaiser; Alnaami, Abdullah M.; Alfawaz, Hanan; Al-Ajlan, Abdulrahman; Kumar, Sudhesh; Chrousos, George P.; Alokail, Majed S.

doi:10.1016/j.jacl.2014.11.001

Cited by 6 publications

(3 citation statements)

References 21 publications

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“…Other cross-sectional studies have described changes of lipid levels by age during childhood and adolescence, in a similar way to the previous Lebanese report [11], with a tendency toward worsening of lipid profile in boys and improvement in girls after puberty [4, 12–14]. These studies were performed in US [7, 12–14], Europe [15, 16] and in the Middle-East [17], but longitudinal studies are sparse [18, 19].…”

Section: Introductionsupporting

confidence: 75%

Longitudinal changes of lipid profile in the Lebanese pediatric population

2019

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BackgroundFew studies looked at the prevalence of dyslipidemia in pediatric Middle-Eastern countries. In addition, worldwide longitudinal changes of lipid profile is not well documented. The purpose of this study is to look at the longitudinal changes of lipid parameters in Lebanese school-age children.Materials and methodsA total of 97 subjects (41 girls and 56 boys) aged between 11 and 21 years were included in this study. The subjects were selected among 339 school-age children with a previous abnormal lipid profile who were recruited from 10 schools of varying socio-economic levels (SEL). A fasting lipid profile [total cholesterol (TC), triglycerides (TG) and HDL-cholesterol (HDL-C)] was performed. Non-HDL-cholesterol (Non-HDL-C) was calculated. Weight and height were measured under the same conditions, and BMI percentiles were calculated. A multivariate covariance analysis model (MANCOVA) was used with TG, HDL-C and non-HDL-C as dependent variables with additional post-MANCOVA F tests.ResultsThe age of the current cohort is 16.5 ± 2.9 years with no significant difference according to gender. The current lipid profile was obtained 3.1 ± 0.7 years following the initial one, with 53.6% of the subjects having it normalized. TC, TG, and non-HDL-C decreased significantly over time in girls, while only TG decreased significantly in boys. No significant changes were observed for HDL-C. Using MANCOVA, a significant time by age interaction was observed (p < 0.0001), while gender, BMI and SEL were found not to be significant. Post-hoc F tests showed that the time by age interaction was driven by TG (p = 0.03) and non-HDL-C (p < 0.001), the larger effect being observed in younger children.ConclusionA high proportion of school-age children normalize their abnormal lipid profile with time. Screening for lipid disorders could be postponed until post puberty age.

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Section: Introductionsupporting

confidence: 75%

Longitudinal changes of lipid profile in the Lebanese pediatric population

2019

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“…This is consistent with the findings of previous studies (4,13). Although Al-Daghari et al (20) reported a higher risk of high non-HDL-C in girls, they also noted that high serum non-HDL-C concentrations was associated with more cardiometabolic risks in boys than girls. The higher frequency of high non-HDL-C in girls may be explained by the observed higher prevalence of overweight/obesity in girls than boys, both in the present study as well as in others (4,12).…”

Section: Discussionmentioning

confidence: 92%

Serum non-high-density lipoprotein cholesterol concentration: Profile and prevalence of high levels among adolescent Nigerian students

Onyiriuka¹,

Iduoriyekemwen²,

Sadoh³

2019

Sri Lanka J. Diabetes Endocrinol. Metab.

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Keywords: Adolescence, non-high-density lipoprotein cholesterol, obesity, overweight, Nigeria.Correspondence: e-mail< alpndiony@yahoo.com>. Background/Aim: Non-high-density lipoprotein cholesterol (non-HDL-C) concentration include both cholesterol-rich and triglycerides-rich atherogenic apolipoprotein B-containing lipoproteins. The present study described the distribution and estimated the prevalence of high serum non-HDL-C levels in adolescent Nigerian students.Methods: This was a case control study, conducted in an urban secondary school. The study population consists of a total of 98 students, aged 10-16 years (49 subjects with high BMI ( ≥ 85th percentile) and 49 controls with normal BMI (5th to < 85th percentile). The first school in an alphabetically arranged list was selected. The participants were randomly selected and matched for age and sex. The serum concentrations of total cholesterol (TC), high-density lipoprotein-cholesterol (HDL-C), triglycerides (TG) and low-density lipoprotein-cholesterol (LDL-C) were determined, using automated analyzer with commercially available kits. The serum non-HDL-C concentration was determined from the difference between the TC and HDL-C concentrations.Results: The prevalence of elevated (borderline plus abnormal) non-HDL-C concentrations in overweight/obese and normal-weight participants were 26.5% (95% CI=26.3-26.6) and 8.2% (95% CI = 5.9-14.5) respectively; Z-test statistic = 2.666, p < 0.01. In overweight/obese participants, the prevalence rates of "borderline" and "abnormal" serum non-HDL-C levels were 24.5% and 2.0%, respectively. The corresponding prevalence rates in normal-weight participants were 8.2% and zero percent, respectively. The frequency of high non-HDL-C was higher in participants whose waist-to-height ratio (WHtR) was ≥ 0.5 than those with WHtR < 0.5. The risk of high serum non-HDL-C level was 2.5-fold higher in girls than boys. The mean serum non-HDL-C concentrations in overweight/obese and normal weight participants were 101.4±23.3mg/dl and 93.6±24.8mg/dl, respectively; p>0.05. The mean serum non-HDL-C in overweight/obese boys was 3.9mg/dl higher than that of normal weight boys and for the girls, this difference was 10.8mg/dl. Conclusion:The risk of developing a significantly elevated non-HDL-C level is greater in overweight/obese than normalweight adolescents and this risk is also greater in girls.

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“…Children with chronic diseases, such as type 1 diabetes mellitus (T1DM) and asthma, as well as those on medications that might influence the metabolic parameters of interest, were excluded. Subjects were recruited randomly from different Primary Health Care Centers (PHCC) across Riyadh as previously described [ 28 ]. Each participating subject submitted a general questionnaire containing demographic, past and present medical history, as well as diet information from the food frequency questionnaire.…”

Section: Methodsmentioning

confidence: 99%

Gender-specific associations of serum sex hormone-binding globulin with features of metabolic syndrome in children

Al-Daghri

Khan

Sabico

et al. 2016

Diabetol Metab Syndr

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BackgroundSex hormone-binding globulin (SHBG) has been proposed as a biomarker of MetS in children and adults. We aim to determine the associations of SHBG with components of MetS in children from the Middle-East where the prevalence of MetS are on the rise.MethodsIn this cross-sectional study, a total of 509 randomly selected school children (226 boys and 283 girls) aged 12–16 years were recruited. Fasting blood glucose and lipid profile were determined using routine laboratory procedures. Serum SHBG is measured with Cobas e411 using an electrochemiluminescence immunoassay. The modified definition of ATP-III (NHANES III) was used for the diagnosis of MetS.ResultsAmong 509 children, 23.4 % had metabolic syndrome. Boys had a significantly higher waist circumference and systolic blood pressure (p < 0.032, 0.024, respectively) than girls, while levels of glucose (p < 0.029), and SHBG (p < 0.003) were significantly higher in girls than in boys. In overall population, a significant inverse correlation of SHBG level with age, BMI, systolic blood pressure and triglycerides and a significant direct correlation between SHBG level and HDL-c was exhibited. Children with the lowest tertile of serum SHBG had significantly higher prevalence of MetS (p < 0.05). ROC curve shows SHBG level as more sensitive marker of MetS in boys (AUC = 0.70, p < 0.001).ConclusionsSerum SHBG is significantly more sensitive in identifying MetS in boys, not girls, indicating gender dimorphism.Electronic supplementary materialThe online version of this article (doi:10.1186/s13098-016-0134-8) contains supplementary material, which is available to authorized users.

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Non–high-density lipoprotein cholesterol and other lipid indices vs elevated glucose risk in Arab adolescents

Cited by 6 publications

References 21 publications

Longitudinal changes of lipid profile in the Lebanese pediatric population

Longitudinal changes of lipid profile in the Lebanese pediatric population

Serum non-high-density lipoprotein cholesterol concentration: Profile and prevalence of high levels among adolescent Nigerian students

Gender-specific associations of serum sex hormone-binding globulin with features of metabolic syndrome in children

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