Non-Hodgkin lymphoma presenting with numb chin syndrome

Fan, Yuan; Luka, Rimas; Noronha, Avertano

doi:10.1136/bcr.01.2011.3712.corr1

Cited by 16 publications

(5 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There have been several other case reports of NCS where there has been no evidence of a metastatic lesion in the mandible or base of skull on imaging. 18,20 It is important to remember that lack of radiographic changes cannot exclude the possibility of small metastatic lesions in the jaw. 21 Friedrich reported a case of tumour infiltration of the inferior alveolar nerve inside the mandibular canal that was found on surgical exploration after a negative CT scan.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Unusual presentation of ‘numb chin syndrome’ as the manifestation of metastatic adenocarcinoma of the lung

Zaheer

Hussain²,

Rao

2013

International Journal of Surgery Case Reports

View full text Add to dashboard Cite

INTRODUCTIONNumb chin syndrome (NCS) is the presence of hypoaesthesia or paraethesia of the lip and chin over the distribution of the mental nerve. It is often caused by the presence of a metastatic tumour in the mandible or the base of skull and represents advanced malignancy.PRESENTATION OF CASEThis paper presents an unusual case of NCS associated with metastatic adenocarcinoma of the lung, for which no obvious lesion was found in the mandible or base of the skull.DISCUSSIONNCS can oftentimes present itself in the absence of mandibular or base of skull metastatic lesions.CONCLUSIONNCS can be a sign of underlying advanced metastatic malignancy and therefore cannot be ignored and must be investigated fully.

show abstract

Section: Discussionmentioning

confidence: 99%

“… 2,15 Current expert opinion is that NCS of unknown cause is to be treated as suspected malignancy until proven otherwise. 18 …”

Section: Introductionmentioning

confidence: 99%

Unusual presentation of ‘numb chin syndrome’ as the manifestation of metastatic adenocarcinoma of the lung

Zaheer

Hussain²,

Rao

2013

International Journal of Surgery Case Reports

View full text Add to dashboard Cite

show abstract

“…[ 7 ] In rare cases, a numb chin syndrome can be the only symptom, which should always be considered as a sign of malignancy. [ 8 ] Radiological signs are expansion of the bone, enlargement of the mandibular canal and mental foramen, and alveolar bone loss. In advanced stages, bone destruction can occur, appearing as a solitary defect or resorption of the alveolar bone margin, which resembles periodontitis or a periodontal abscess.…”

Section: Introductionmentioning

confidence: 99%

Numb chin as signal for malignancy-primary intraosseous diffuse large B-Cell lymphoma of the mandible

Fuessinger

Voss

Metzger

et al. 2018

Ann Maxillofac Surg

View full text Add to dashboard Cite

Malignant lymphomas are about 5% of all malignant tumors. Extranodal non-Hodgkin's lymphomas (NHLs) are found in 26% of these cases. Lymphomas of the head-and-neck area occur in 2%–3% of all malignancies, with 28% with an extranodal manifestation. Extranodal NHLs in the oral cavity are usually found in the maxilla, and rarely in the mandible. Their symptoms and clinical manifestation have no pathognomonic features; therefore, the expression of this uncommon entity can be diagnosed with an odontogenic inflammatory process, leading to a misdiagnosis. Delay in the decision for a biopsy, and adequate treatment for the patient directly impairs the prognosis of this neoplasm. This study reports a case of a patient with discomfort in the right mandible and paresthesia of the right lower lip and chin without any dental focus. After performing further diagnostic examinations including a subsequent biopsy, the final diagnosis was a diffuse large B-cell lymphoma (DLBCL). Intraosseous DLBCLs are uncommon in the daily clinical routine, but emphasize the need for careful examination by the clinicians also considering the differential diagnosis of sensory neuropathy. Neurological symptoms with no apparent cause should raise the suspicion of malignancy until the opposite is proven.

show abstract

“…The authors suggested a possible mechanism of microscopic seeding of the malignant cell in the nerve, which is not visible in radiological imaging. This could be another mechanism causing numb chin syndrome [11]. …”

Section: Discussionmentioning

confidence: 99%

Bilateral Numb Chin Syndrome as the Initial Presentation of Burkitt’s Lymphoma/Leukemia: A Report of Two Cases and Review of the Literature

Algahtani

Shirah

Bassuni

et al. 2016

Case Reports in Hematology

View full text Add to dashboard Cite

Numb chin syndrome, also known as mental nerve neuropathy, is a rare sensory neuropathy characterized by paresthesia and hypoesthesia in the area supplied by the mental nerve and its branches. This syndrome may be the first symptom of underlying malignancy or the first sign of recurrence and metastasis in patients with preexisting cancer. In this article, we present two cases with bilateral numb chin syndrome as the first manifestation of Burkitt's lymphoma/leukemia and review the relevant literature. Numb chin syndrome should be considered as a warning sign and raise the suspicion for an underlying malignancy. Bilateral involvement is especially hazardous and must not be underestimated. In fact, an astute neurologist and internist who realizes that chin numbness is a potentially significant symptom can then exclude serious underlying malignancies. Standard diagnostic protocol with different modalities of imaging based on the availability and experience of the radiology team should be mandatory. High index of suspicion should be practiced to avoid delay in diagnosis and progression of the underlying malignancy.

show abstract

Non-Hodgkin lymphoma presenting with numb chin syndrome

Abstract: There is an error in the author list of this article. The spelling of the second author's name 'Rimas Luka' is incorrect and it should be the following correct spelling, 'Rimas Lukas'.

Cited by 16 publications

References 0 publications

Unusual presentation of ‘numb chin syndrome’ as the manifestation of metastatic adenocarcinoma of the lung

Unusual presentation of ‘numb chin syndrome’ as the manifestation of metastatic adenocarcinoma of the lung

Numb chin as signal for malignancy-primary intraosseous diffuse large B-Cell lymphoma of the mandible

Bilateral Numb Chin Syndrome as the Initial Presentation of Burkitt’s Lymphoma/Leukemia: A Report of Two Cases and Review of the Literature

Contact Info

Product

Resources

About