Non-Hodgkin′s lymphoma: A rare diagnosis on cervicovaginal cytology

Abstract

Cervicovaginal smear screening is well known to reduce morbidity and mortality rates of invasive cervical carcinoma. Herein, we report a case of 56-year-old woman whose cervicovaginal smear was found to consist of malignant cells characterized by high nuclear/cytoplasmic ratio, scant rim of cytoplasm, coarsely granular nuclear chromatin and irregular nuclear membrane that were all reminiscent of a malignant lymphoma. Histopathological examination of the hysterectomy and unilateral adnexectomy specimen confirmed the presence of a diffuse large B-cell non Hodgkin's lymphoma involving the cervix, endometrium, myometrium, serosa and the right ovary.

Primary large B‐cell lymphoma of the cervix: A case report and review of literature

“…Primary female genital lymphomas are extremely rare neoplasms that make up 0.2% to 1.1% of all extra‐nodal cases 2 . The age range at the time of the diagnosis is generally wide (20–80 years) with an average age of 40–59 years old 5 . The two presented cases in this article were younger than the mean age reported in the medical literature.…”

“…2 The age range at the time of the diagnosis is generally wide (20–80 years) with an average age of 40–59 years old. 5 The two presented cases in this article were younger than the mean age reported in the medical literature. In the literature review, DLBCL were the most frequent histologic type reported, as in the two cases introduced in the present article.…”

Primary Large B Cell Lymphoma of the Cervix: A Case Report and review of literature

“…The age range at the time of the diagnosis is generally wide (20 to 80 years) with an average age of 40 to 59 years old. (5). In the literature review, diffuse large B-cell lymphomas (DLBCL) were the most frequent histologic type reported (6).…”

Lymphoma of the Cervix: Case Report and Review of the Literature

“…For example, Yalta et al describe a case of LUCX where the imunohistochemical profile showed positivity for LCA, vimentin, CD20, CD30, Bcl6, Bcl2. The Ki-67 index was found to be 80% (35). Based on the histopathological appearance of LUCX the most important histopathological differential diagnoses include follicular or chronic cervicitis, small cell carcinoma, endometrial stromal sarcoma, and granulocytic sarcoma (35).…”

“…The Ki-67 index was found to be 80% (35). Based on the histopathological appearance of LUCX the most important histopathological differential diagnoses include follicular or chronic cervicitis, small cell carcinoma, endometrial stromal sarcoma, and granulocytic sarcoma (35). Dyer et al described positivity for CD20, BCL6, IgMk and negativity for CD10, MUM1, and BCL2 as typical for diffuse large B-cell LUCX (88).…”