Non-Hodgkin's lymphoma of the urethra: A rare extranodal entity

Primary Non-Hodgkin’s Lymphoma of the Male Urethra

“…With regard to primary extranodal lymphomas, only 2.7% are located in the geni tourinary system [24], and only rarely is the urethra involved: in immunocompetent patients we found only 4 Male Urethra cases of primary NHL in the urethra, all of them females, in spite of an intensive search of the literature so far [9][10][11][12]. In the case of a 51-year-old female patient a urethral NHL was diagnosed in a biopsy specimen and subse quently treated with combined chemotherapy which led to complete remission [10].…”

“…Because all primary NHLs of the urethra reported so far in immunocompetent persons were found in female patients, Nabholtz et al [11] developed the theory of an etiologic association between urethral NHL and females. At that time no NHL of the urethra had been described in male patients.…”

“…In the case of a 51-year-old female patient a urethral NHL was diagnosed in a biopsy specimen and subse quently treated with combined chemotherapy which led to complete remission [10]. Nabholtz et al [11] surgical ly removed a urethral NHL from a 63-year-old woman and subsequently applied adjuvant polychemotherapy. Another case of an extranodal low grade malignant NHL in a female urethra, described by Mark et al [12], was successfully treated by resection and radiotherapy.…”

“…In 1992 Mostofi et al [5] collected and reviewed about 600 cases of urethral carcinomas world-wide, con sisting of urothelial and squamous cell carcinomas and, rarely, papillary adenocarcinomas [6], Even more uncom mon is the occurrence of primary non-Hodgkin's lympho mas (NHLs) in the urethra [7], To our knowledge a prima ry extranodal manifestation of NHL in the urethra, i.e. of the mucosa-associated lymphoid tissue (MALT) type [8], has been described only in 4 female immunocompetent patients [9][10][11][12], A probable secondary involvement of a nodal NHL in the urethra of 2 further cases, as reported in the patients' histories [13,14], seems to be a relatively Received: September 15,1994 Accepted after revision: March 8,1995 more frequent event in the urinary tract than its primary occurrence [15][16][17], Additionally in male AIDS patients 2 recent case reports of urethral NHL were published [18,19], which may be related to the higher lymphoma inci dence in immunodeficient persons with HIV infection , In the present report a primary extranodal NHL of the male urethra is described, and it seems to be the first documented case (to our knowledge) in a male patient without an immunodeficiency status. …”

A case of intraepithelial squamous cell carcinoma arising from urethral caruncle

“…Some types of neoplasms, such as Non-Hodgkin's lymphoma, malignant melanoma and ovarian tumours, have a urethral caruncle-like appearance. [8][9][10] Marshall and colleagues reported that 2.4% of all patients with a preoperative diagnosis of urethral caruncle were found to have either carcinoma (1.6%) or Bowen's disease (0.8%) in a series of 376 patients. 6 Urethral carcinoma resembling a urethral caruncle is also rarely observed.…”