Non hodgkin′s lymphoma of tongue - A case report

Abstract

Primary non-Hodgkin's lymphoma (NHL) of the oral region is rare. Oral manifestations are present in 3-5% of cases of NHL and oral lesions are rarely the initial manifestation. We describe a 40 year old male who presented with a mass lesion primarily involving the tongue and was diagnosed as diffuse large B cell lymphoma. The patient was treated with CHOP chemotherapy with complete disappearance of lesion after first cycle. Pertinent literature is being reviewed.

Fine needle aspiration cytology of oral and oropharyngeal lesions with an emphasis on the diagnostic utility and pitfalls

“…[21,22] Oral manifestations are present in only 3-5% of the cases of NHL. [23] There were three cases of palatal NHL including a mucosa-associated lymphoid tissue (MALT) lymphoma in the present study. Two false-negative cases with sampling error in the present study highlight the difficulties in approaching the posterior soft palate lesions for FNAC.…”

Primary non-Hodgkin's lymphoma of the tongue: a diagnostic dilemma of unusual case presentation

“…Lip paraesthesia and pathological fracture may be reported as a common sign of jaw involvement 25. On histology, these tumours typically demonstrated a mixture of pleomorphic malignant T cells with few reactive cells infiltrate, such as eosinophil and histiocytes.Tongue lymphomas are usually made of B-cell origin 1 8. The patient's tumour of the presented case was of the T-cell type as confirmed by immunohistochemical phenotyping.…”

“…The head and neck is the second most common site for extranodal lymphomas after the gastrointestinal tract 9. Waldyer's ring lymphomas are the most common area of malignant lymphoma 1. The intraoral location is not common; it comprises only 2% of all extranodal lymphomas 10 11.…”

“…Guevara-Canales et al 14 in their systematic review of 714 patients from 1990 to 2010 found that Waldeyer's ring was the most frequent extraoral site, whereas gingiva was the most frequent intraoral site. The predisposing factors of oral NHLs have not been identified yet, although few cases have reported an association with HIV infection 1 2. Oral NHLs have similar clinical appearance of a more commonly benign oral lesions 15.…”

“…In total, 8–13% of lymphomas involve the head and neck region 1 2. Pazoki et al 3 reported four cases of primary extranodal NHL of jaw bones and reviewed the literature about extranodal NHL affecting the hard tissue.…”