Introduction: Primary non-Hodgkin’s lymphomas (NHLs) of the oral cavity, especially in the tongue, are extremely rare and account for 1% of all malignant tumors of the oral cavity, accounting for 7% of all primary Waldeyer’s ring NHLs. Clinical features are non-specific ulcerative lesions that do not heal, making its diagnosis challenging. Fine-needle aspiration biopsy was helpful in the early diagnosis of the intraoral NHL involving a cervical lymph node. Case Report: we present a rare case of extranodal NHL of the base of tongue in a 55-year-old female who presented with a mass in the base of the tongue with cervical lymphadenopathy. The diagnosis was confirmed as primary NHL diffuse large B cell type by histopathological and immunohistochemistry results. Conclusion: A careful clinical evaluation supported by histopathological and radiologic investigations will help identify the disease early, resulting in a better prognosis.