Non-infiltrating angiolipoma of the cheek: a case report and review of the literature

Abstract

Angiolipoma, spindle cell lipoma, mylelolipoma, chondrolipoma and myxolipoma are histologic variants of lipomas arising from fat tissue. Although angiolipoma is the most common tumor in the trunk and extremities of young people, it occurs infrequently in the head and neck region. The authors present the clinical and histological features of a non-infiltrating angiolipoma excised from the cheek of a 22-year old man. Clinical examination showed a soft, mobile, approximately 4 x 3 cm mass that could be palpated anterior to the masseter muscle. The mass was removed by an intraoral approach. Angiolipoma was confirmed on histopathologic evaluation. Lipomas represent about 1 to 5% of all neoplasms of the oral cavity. They are usually painless, soft, round and mobile. The diagnosis is based on both clinical and histologic characteristics. The treatment is surgical excision.

Oral lipomas in a Brazilian population: A 10-year study and analysis of 450 cases reported in the literature

“…Angiolipomas usually affect male adolescents and subjects in their early twenties. Infiltrating angiolipomas are typically diagnosed in older patients (17). In the present series, a 65-yearold woman exhibited areas of blood vessel formation amidst mature adipose tissue in the absence of fibrin thrombi, findings that led to the histological diagnosis of noninfiltrating angiolipoma.…”

“…In the present series, a 65-yearold woman exhibited areas of blood vessel formation amidst mature adipose tissue in the absence of fibrin thrombi, findings that led to the histological diagnosis of noninfiltrating angiolipoma. However, in the case of histological observation of abundant vascularity, careful examination should be performed to exclude angiosarcoma and Kaposi's sarcoma (17). Myxoid lipomas of the oral cavity are rare (1).…”

Oral soft-tissue angiolipoma: report of two cases of rare oral lipomatous lesion with emphasis on morphological and immunohistochemical features

“…Hamakawa et al (1) reported one case of angiolipoma of the cheek and reviewed nine previously reported cases of oral soft-tissue angiolipomas. Subsequently, nine additional cases were reported in the English literature, raising the total number of reported cases from 1976 to 2012 to 19 (3)(4)(5)(6)(7)(8). Male to female ratio from these intraoral angiolipomas was 1.4:1, in contrast to cutaneous angiolipomas and intraoral lipomas as a group, which either shows no sex predilection or a slight female predilection (2).…”

“…Pathogenesis of angiolipomas remains unclear, but history of trauma, lipomatous hormonal differentiation during puberty, fatty degeneration in hemangiomas and vascular proliferation in congenital lipomas have been suggested as possible associated causative factors (5,6). Most angiolipomas show a normal karyotype, suggesting that these tumors can represent reactive non-neoplastic proliferations.…”

Recurrent Infiltrating Angiolipoma – Complete Response to Radiation- A Case Report

“…Angiolipoma is a variant of lipoma exhibiting proliferating capillaries admixed with mature adipocytes. Angiolipoma was first defined by Bowen in 1912 [1] and differentiated from lipomas; histopathologically by Howard in 1960 [2] it has a rich vascular component and is classified as infiltrating and non-infiltrating. The infiltrating lesions are usually non capsulated orrarely encapsulate partially and tends to infiltrate bony, neural, muscular and fibro cartilaginous tissues, often making a complete resection difficult.…”