populations. Moreover, with the advent of the novel coronavirus disease (COVID-19), significant investment in medical resources is required. Under the umbrella of the global COVID-19 pandemic, the use of biosensors in healthcare and online medical care are becoming ubiquitous, which represent methods that can be used to detect signs from the human body for further health analysis. Furthermore, the internet of things (IoT) technology in healthcare is a method by which biosensorembedded objects can be worn on the human body in everyday life that continuously measure and digitize health information without any burden to the wearer. [1] Recently, various biometric technologies have been developed, wearable devices such as smart watches, invasive biodevices, and devices that sense the everyday surrounding environment of the wearer. Medical data can be collected using such devices, which can then be further analyzed by artificial intelligence (AI). These data can then be used for health promotion, prevention of disease, and early disease diagnosis. Moreover, with the advent of COVID-19, healthcare IoT (HIoT) technology has become extremely important. [2] In terms of the individual, when a mask is constantly worn it may cause lung damage to the user. Therefore, the HIoT would make a significant contribution in this case to offer forewarning about the situations of the lungs As society advances, the shift from passive medical care to health management and preventive medical care has become an important issue, with the realization of wearable monitors becoming desirable. In light of the COVID-19 pandemic, the number of patients who are in urgent need of the monitoring of biological information is increasing. This review focuses on piezoelectric materials and composites that convert kinetic energy into electrical energy to realize self-powered wearable monitoring sensors, outlining the recent research activity on sensors for use in healthcare monitoring. First, a general description of the principles of piezoelectric monitoring sensors is given. Next, the development status of piezoelectric materials and composites aimed at the application of detecting tiny motions of the human body is introduced, and then the research trends on the detection of larger human body movements are highlighted. Finally, after presenting the performance of current piezoelectric sensors and future research guidelines for developing multifunctional systems in the post COVID-19 era, the achievements are summarized. Overall, this review will provide guidance to researchers who are seeking to design and develop highly sensitive self-powered piezoelectric sensors that monitor human motion and physiological signals.The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10.1002/admt.202200318.