Non-invasive analysis of metabolic reactions in body tissues, the case of myocardial fatty acids

Feinendegen, L. E.; Vyska, K.; Freundlieb, C.; Höck, A.; Machulla, Hans-Juergen; Kloster, G.; Stöcklin, G.

doi:10.1007/bf00290563

Cited by 54 publications

(14 citation statements)

References 2 publications

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“…Patients with dilated cardiomyopathy demonstrated significantly greater regional variability in the myocardial clearance of palmitate 1~C than did normal subjects (Sochor et al 1986). The regional heterogeneity of palmitate 11C accumulation has been confirmed with a23I-FFA analogues (Feinendegen et al 1981;Ugolini et al 1988).…”

Section: Cardiomyopathiesmentioning

confidence: 62%

“…As an alternative to PET, ~23I allows the labelling of a variety of fatty acids and their analogues for metabolic studies (Feinendegen et al 1981;Poe et al 1976). The unsaturated, 16-123I-iodohexadecanoic acid, a 16-carbon chain fatty acid, and the saturated 17-carbon analogue, 17-~23I-iodoheptadecanoic acid, are rapidly metabolised by the heart and liver (Freundlieb et al 1980).…”

Section: Free Fatty Acm Metabolismmentioning

confidence: 98%

“…Radioiodinated phenyl fatty acids, such as 123I-iodophenylpentadecanoic acid, provide a solution to the problem of deiodination because their /?-oxidation results in the release of iodobenzoic acid rather than free iodide as with alkyl fatty acids (Feinendegen et al 1981 ;Keriel et al 1990). Iodobenzoic acid is then oxidized to hippuric acid and rapidly excreted in the urine (Machulla et al 1980).…”

Section: Free Fatty Acm Metabolismmentioning

confidence: 99%

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Complementarity of magnetic resonance spectroscopy, positron emission tomography and single photon emission tomography for the in vivo investigation of human cardiac metabolism and neurotransmission

Syrota¹,

Jehenson²

1991

Eur J Nucl Med

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The three techniques allowing the noninvasive study of cardiac metabolism, namely magnetic resonance spectroscopy (MRS), positron emission tomography (PET) and single photon emission computed tomography (SPET), all use external detection with stable or radioactive isotopes. These techniques yield different information. PET is quantitative and very sensitive, and therefore only tracer amounts of molecules need to be injected. It allows neurotransmitters and receptors to be studied and a global view of metabolism (oxygen consumption, glucose and fatty acid utilization) to be obtained. SPET also has good sensitivity, but uses gamma-emitting isotopes of heteroatoms. Their longer half-lives allow follow-up for hours or days. MRS is based on stable elements with high (hydrogen 1, phosphorus 31, fluorine 19...) or low (carbon 13, Deuterium) natural abundance. It has very low sensitivity and only millimolar concentrations of substrates can be detected, but various parts of metabolism can be studied. The in vivo measurement of myocardial concentration of substances has many problems that are common to all three techniques (measurement of the volume, measurement of the quantity of each molecule, resolution, partial volume effect, improvement of the signal-to-noise ratio, movement of the organ). The complementarity of the techniques is illustrated by their applications to the study of cardiac metabolism. For instance, the energy metabolism can be studied by 31P-MRS, which detects the high-energy compounds ATP and phosphocreatine, and 13C-MRS yields information on the tricarboxylic acid cycle activity. PET and SPET allow the utilization of fatty acids, the normal fuels of the heart, to be studied. During ischaemia, PET with 18F-fluorodeoxyglucose (18FDG) can determine the glucose consumption and 1H-MRS shows the increase in lactic acid, reflecting anaerobic glycolysis. Comparison of the use of acetate labelled with 11C for PET or 13C for MRS shows the potentials and limitations of each technique. Myocardial perfusion can be evaluated directly with various PET tracers or indirectly with thallium 201 or various technetium-99m-labelled tracers by SPET. No MRS marker of perfusion is so far clinically available. Mainly SPET and PET are used clinically for the investigation of ischaemic heart disease as well as cardiomyopathies, but some initial results using 31P-MRS are being obtained.

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Section: Cardiomyopathiesmentioning

confidence: 62%

Section: Free Fatty Acm Metabolismmentioning

confidence: 98%

Section: Free Fatty Acm Metabolismmentioning

confidence: 99%

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Complementarity of magnetic resonance spectroscopy, positron emission tomography and single photon emission tomography for the in vivo investigation of human cardiac metabolism and neurotransmission

Syrota¹,

Jehenson²

1991

Eur J Nucl Med

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“…The former (c-type) seems to dominate with an irreversible, stabilized condition, the other (d-type) (2) is attributed to ischaemia, i.e. to viable myocardium which is not irreversibly injured" 4 ' and, thus, non-stable myocardium.…”

Section: The Resultsmentioning

confidence: 99%

On the Prognostic Potential of the Sequential 123-I-HDA-Tomoscintigram After the First MI

Rösler¹,

Noelpp²,

Tóth³

et al. 1985

European Heart Journal

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“…injection of IHA was iodide, which contributes substantially to the radioactive background observed in gamma camera studies [4,5]. Methods of correction for catabolite activity were proposed [4,6,7]. Thus, IHA has been used for a number of clinical studies of coronary artery disease and cardiomyopathies [5,6,[8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Beta-oxidation of 1-[14C]-17-[131I]-iodoheptadecanoic acid following intracoronary injection in humans results in similar release of both tracers

et al. 1993

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Radioiodine labelled 17-iodo-heptadecanoic acid (IHA) is used for non-invasive study of myocardial metabolism in coronary heart disease and cardiomyopathy. Yet in the interpretation of in vivo myocardial tracer kinetics, it is controversial whether the intracellular degradation of IHA or the removal of iodide across cellular membranes is the rate-limiting step in iodide release from the myocardium. In five patients undergoing coronary sinus catheterization, a mixture of about 40 kBq of [123I] NaI was injected into the left coronary artery. During the following 15-min period, frequent blood samples were taken from the aorta and the coronary sinus. In the aqueous phase of the venous blood, 14CO2 and inorganic 131I appeared nearly in parallel, with a peak time of 4-5 min. Moreover, as shown by the AV difference, there was no significant back diffusion of IHA and no significant non-specific deiodination detectable over the period of observation. There was myocardial retention of inorganic iodide (123I) injected into the left coronary artery. The data strongly support the premise that lipid turnover through beta-oxidation is the rate-limiting step in the externally measured release of iodide after IHA injection, provided that recirculating inorganic radioactive iodide is corrected for. In addition, 15 volunteers were studied using [11C]palmitic acid and [123I]IHA using PET and dynamic planar camera scintigraphy with iodide correction. There was no significant difference between the mean values of the elimination half-times, and also no significant correlation between half-times of both fatty acids for single individuals.

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Non-invasive analysis of metabolic reactions in body tissues, the case of myocardial fatty acids

Cited by 54 publications

References 2 publications

Complementarity of magnetic resonance spectroscopy, positron emission tomography and single photon emission tomography for the in vivo investigation of human cardiac metabolism and neurotransmission

Complementarity of magnetic resonance spectroscopy, positron emission tomography and single photon emission tomography for the in vivo investigation of human cardiac metabolism and neurotransmission

On the Prognostic Potential of the Sequential 123-I-HDA-Tomoscintigram After the First MI

Beta-oxidation of 1-[14C]-17-[131I]-iodoheptadecanoic acid following intracoronary injection in humans results in similar release of both tracers

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