Non-invasive assessment of the age related changes in stiffness of major branches of the human arteries

Kawasaki, Takeshi; Sasayama, Shígetake; Yagi, Shinichi; Asakawa, Tetsuya; Hirai, Tadakazu

doi:10.1093/cvr/21.9.678

Cited by 613 publications

(388 citation statements)

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“…where ln is the natural logarithm, Ps is systolic and Pd is diastolic blood pressures in mmHg, Dd is diastolic aortic diameter and Ds is systolic aortic diameter 16 . Results are based on mean β stiffness index from three assessments.…”

Section: Methodsmentioning

confidence: 99%

Predictive markers of abdominal aortic stiffness measured by echo-tracking in subjects with varying insulin sensitivity

2014

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Predictive markers of abdominal aortic stiffness measured by echo-tracking in subjects with varying insulin sensitivity. Link to publication Citation for published version (APA): Gottsäter, M., Länne, T., & Nilsson, P. M. (2014). Predictive markers of abdominal aortic stiffness measured by echo-tracking in subjects with varying insulin sensitivity. Journal of Human Hypertension, 28(7), 456-460. DOI: 10.1038456-460. DOI: 10. /jhh.2013 General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal AbstractArterial stiffness is influenced by advancing age and vascular disease and is an independent risk factor for cardiovascular events and death. Using ultrasound measurements, arterial stiffness in a specific arterial segment can be assessed. The aim of this observational study was to explore the prospective and cross-sectional associations between arterial stiffness measured by ultrasound locally in the abdominal aorta and cardiovascular risk factors/markers including insulin resistance measured by the homeostatic model assessment -insulin resistance (HOMA-IR), lipids and abdominal obesity.This study includes 335 subjects from Malmö, Sweden, examined in 1991 and again at follow-up in 1998-2000. Ultrasound measurement of the abdominal aorta was performed at follow-up investigation.In the female subgroup, there was a positive association between HOMA-IR at baseline and abdominal aortic stiffness at follow-up (beta=0.18, p=0.03) and a negative association between high density lipoprotein and aortic stiffness (beta=-0.23, p=0.005), independently of classical cardiovascular risk factors. These associations were not found among men. The results suggest a greater or different role of impaired glucose metabolism in the pathophysiology of arterial stiffness in women than in men.

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Section: Methodsmentioning

confidence: 99%

Predictive markers of abdominal aortic stiffness measured by echo-tracking in subjects with varying insulin sensitivity

2014

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“…Elastic modulus, distensibility, and stiffness index β are the methods used for a local assessment of arterial stiffness 33, 34. However, validity and reproducibility of these methods are limited because of their dependence on the patient's blood pressure 7, 9.…”

Section: Discussionmentioning

confidence: 99%

Ascending Aortic Strain Analysis Using 2‐Dimensional Speckle Tracking Echocardiography Improves the Diagnostics for Coronary Artery Stenosis in Patients With Suspected Stable Angina Pectoris

Fan

et al. 2018

JAHA

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BackgroundArterial stiffening and atherosclerosis tend to coexist. Strain imaging, using a 2‐dimensional speckle tracking (2D‐ST) method, has been used for arterial stiffness assessment and early identification of atherosclerosis. We investigated whether the ascending aortic strain assessed by 2D‐ST echocardiography at rest can predict the presence of coronary artery disease (CAD).Methods and ResultsTwo hundred seventy‐one consecutive patients with suspected stable angina pectoris sequentially underwent exercise treadmill testing, 2‐dimensional echocardiography, M‐mode echocardiography, 2D‐ST echocardiography, and coronary angiography. Circumferential ascending aortic strain (CAAS) and radial ascending aortic strain were assessed by 2D‐ST echocardiography. Ninety‐two patients with coronary lumen area stenosis ≥70% were categorized as having significant CAD. Global CAAS was significantly lower in patients with significant CAD (7.41±2.30% versus 11.54±4.03%; P<0.001) and remained an independent predictor of significant CAD (odds ratio, 0.64 [0.54–0.75]; P<0.001) after multivariate regression. Based on the receiver operating characteristic curve for diagnosing significant CAD, the optimal cut‐off value of global CAAS was ≤9.22% (sensitivity, 86%; specificity, 70%; area under curve=0.82; P<0.001). Global CAAS decreased with increasing severity of CAD and was significantly associated with 3‐vessel disease (odds ratio, 0.58 [0.42–0.79]; P<0.001). Diagnostics for significant CAD were remarkably better for global CAAS combined with exercise treadmill testing than for exercise treadmill testing alone (area under curve=0.88 versus 0.78; P<0.001).ConclusionsGlobal CAAS assessed by 2D‐ST echocardiography at rest was able to predict the presence of significant CAD and identify multivessel disease. In addition, global CAAS combined with exercise treadmill testing remarkably improved the diagnostics for significant CAD.

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“…These indices are equations that rely on static data, such as end-systolic and end-diastolic diameter or systolic and diastolic blood pressure. 23,24 They result in a single indexed value for compliance, whereas our method can evaluate compliance continuously over time. These indices are also unable to isolate and quantify the individual contributions of radial and longitudinal motion to aortic compliance.…”

Section: Discussionmentioning

confidence: 99%

“…This functioned as control for differences in patients' blood pressure at the time of TEE image acquisition, minimizing its impact as a confounding variable when measuring compliance. Previous work has suggested that aortic pressure may contribute less than changes in volume with regard to indices of aortic compliance 23 ; therefore, the impact of lacking simultaneous invasive pressure measurements should be minimal.…”

Section: Diabetes Mellitus 19 Dyslipidemia 50mentioning

confidence: 99%

Proximal aortic compliance and diastolic function assessed by speckle tracking imaging

Gregory

Dobson

2013

Can J Anesth/J Can Anesth

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Purpose Speckle tracking imaging (STI) is a recent technique that evaluates an echocardiographic image throughout the cardiac cycle and provides dynamic variables such as tissue velocities and strain rates. The objective of our study was to determine 1) if STI can be used to quantify proximal aortic compliance and 2) if decreased aortic compliance determined by STI will reproduce the previously reported correlation with diastolic function. Methods This was a retrospective observational case series using previously obtained intraoperative transesophageal images. Diastolic performance was quantified by STI-based longitudinal velocities of the basal-septal and basal-lateral walls of the left ventricle in early diastole (LV E 0 ). Change in proximal aortic volume was calculated using STI to measure peak longitudinal and radial velocities in early diastole. After normalizing for mean arterial pressure, compliance was calculated and then compared with basal-septal and basal-lateral LV E 0 using single regression analysis.Results Twenty patients were included in our analysis. Linear regression of basal-septal LV E 0 and basal-lateral LV E 0 vs proximal aortic compliance during diastole each resulted in an R 2 value of 0.26 (P \ 0.05). Conclusion Speckle tracking can be used to describe the physical motion of the aortic wall and to calculate its compliance. We confirm that variation in diastolic function can be attributed, in part, to aortic compliance. Our novel approach of measuring compliance throughout the cardiac cycle, isolating radial and longitudinal contributions, and evaluating previously obtained images retrospectively provides advantages over previously reported measures of aortic compliance. Speckle tracking promises new insights into ventricular function, aortic mechanics, and the interaction between these structures. RésuméObjectif L'imagerie de suivi de pixel, ou speckle tracking imaging (STI) en anglais, est une technique re´cente qui permet d'e´valuer une image e´chocardiographique tout au long du cycle cardiaque et d'obtenir des variables dynamiques telles que les ve´locite´s tissulaires et les vitesses de de´formation. L'objectif de notre e´tude e´tait de de´terminer si 1) la STI pouvait eˆtre utilise´e pour quantifier la compliance de l'aorte proximale, et si 2) une compliance aortique re´duite telle que de´termine´e par la STI reproduisait la corre´lation avec la fonction diastolique rapporte´e pre´ce´demment. Méthode Cette e´tude est une se´rie de cas observationnelle re´trospective se fondant sur des images transoesophagiennes perope´ratoires obtenues par le passe´. La performance diastolique a e´te´quantifie´e par les ve´locite´s longitudinales fonde´es sur la STI des parois basales septales et basales late´rales du ventricule gauche en de´but de diastole (LV E 0 ). Les changements de volume de l'aorte proximale ont e´teć alcule´s à l'aide de la STI afin de mesurer les ve´locite´s

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Non-invasive assessment of the age related changes in stiffness of major branches of the human arteries

Cited by 613 publications

References 0 publications

Predictive markers of abdominal aortic stiffness measured by echo-tracking in subjects with varying insulin sensitivity

Predictive markers of abdominal aortic stiffness measured by echo-tracking in subjects with varying insulin sensitivity

Ascending Aortic Strain Analysis Using 2‐Dimensional Speckle Tracking Echocardiography Improves the Diagnostics for Coronary Artery Stenosis in Patients With Suspected Stable Angina Pectoris

Proximal aortic compliance and diastolic function assessed by speckle tracking imaging

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