Non-invasive brain stimulation for negative symptoms in schizophrenia: An updated systematic review and meta-analysis

Osoegawa, Caio; Gomes, July Silveira; Grigolon, Ruth Bartelli; Brietzke, Elisa; Gadelha, Ary; Lacerda, Acioly Luiz Tavares de; Dias, Álvaro Machado; Cordeiro, Quirino; Laranjeira, Ronaldo; Jesus, Danilo de; Daskalakis, Zafiris J.; Brunelin, Jérôme; Cordes, Joachim; Trevizol, Alisson Paulino

doi:10.1016/j.schres.2018.01.010

Cited by 83 publications

(53 citation statements)

References 55 publications

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“…Meticulous homogenous subject selection, standardized neuromodulatory protocol delivery, recording and measuring potential confounding variables (e.g., smoking status, comorbid diabetes, genotyping of important plasticity-related polymorphisms) will go a long way in reducing the inter-individual response variability. Implementing these refined approaches can potentially improve the reliability of cortical plasticity responses, and the true intersubject variability can then be utilized as potential markers of response to not only noninvasive brain stimulation therapies (Osoegawa et al, 2018), but also to antipsychotic medications and cognitive training interventions in schizophrenia.…”

Section: Discussionmentioning

confidence: 99%

Motor cortical plasticity in schizophrenia: A meta-analysis of Transcranial Magnetic Stimulation – Electromyography studies

Mehta

Thanki

Padmanabhan

et al. 2019

Schizophrenia Research

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Background-Several lines of investigations converge upon aberrant synaptic plasticity as a potential pathophysiological characteristic of schizophrenia. In vivo experiments using neuromodulatory perturbation techniques like Transcranial Magnetic and Direct Current Stimulation (TMS & tDCS) have been increasingly used to measure 'motor cortical plasticity' in schizophrenia. A systematic quantification of cortical plasticity and its moderators in schizophrenia is however lacking. Method-The PubMed/MEDLINE database was searched for studies up to December 31 st , 2017 that examined case-control experiments comparing neuromodulation following single-session of TMS or tDCS. The primary outcome was the standardized mean difference for differential changes in motor evoked potential (MEP) amplitudes measured with single-pulse TMS (MEP Δ) between patients and healthy subjects following TMS or tDCS. After examining heterogeneity, metaanalyses were performed using fixed effects models. Results-A total of 16 datasets comparing cortical plasticity (MEP Δ) between 189 schizophrenia patients and 187 healthy controls were included in the meta-analysis. Patients demonstrated diminished MEP Δ with effect sizes (Cohen's d) ranging from 0.66 (LTP-like plasticity) to 0.68 (LTD-like plasticity). Heterosynaptic plasticity studies demonstrated a greater effect size (0.79) compared to homosynaptic plasticity studies (0.62), though not significant (P = 0.43). Clinical, perturbation protocol-and measurement-related factors, and study quality did not significantly moderate the aberrant plasticity demonstrated in schizophrenia. Conclusions-Schizophrenia patients demonstrate diminished LTP-and LTD-like motor cortical plasticity, which is not influenced by the various clinical and experimental protocol related *

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Section: Discussionmentioning

confidence: 99%

Motor cortical plasticity in schizophrenia: A meta-analysis of Transcranial Magnetic Stimulation – Electromyography studies

Mehta

Thanki

Padmanabhan

et al. 2019

Schizophrenia Research

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“…Although most studies focus on pharmacological interventions, some involve techniques known for their efficacy in a other clinical field. Noninvasive brain stimulation methods such as repetitive transcranial magnetic stimulation, (rTMS) and transcranial direct current stimulation (tDCS) have been tested in depression, schizophrenia, autism, and cognitive deficits in AD and MCI ( Wei et al., 2017 ; Barahona-Corrêa et al., 2018 ; Cruz Gonzalez et al., 2018 ; Osoegawa et al., 2018 ). A meta-analysis of randomized controlled trials found rTMS protocols to demonstrate efficacy but not tDCS ( Vacas et al., 2018 ); however, both were found to demonstrate safety and tolerability in the studied population.…”

Section: Promising Therapeutic Options Of Bpsdmentioning

confidence: 99%

Pharmacotherapy of Behavioral and Psychological Symptoms of Dementia: State of the Art and Future Progress

et al. 2020

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The core symptoms of different dementia subtypes are the behavioral and psychological symptoms of dementia (BPSD) and its neuropsychiatric symptoms (NPS). BPSD symptoms may occur at any stage in the case of dementia due to Alzheimer’s disease (AD), whereas they tend to occur early on in the case of its behavioral variant frontotemporal dementia or dementia with Lewy bodies and are essential for diagnosis. BPSD treatment consists of non-pharmacological as well as pharmacological interventions, with non-pharmacological interactions being suggested as first-line treatment. Agitation, psychotic features, apathy, depression, and anxiety may not respond to acetylcholinesterase inhibitors or memantine in AD cases; therefore, antipsychotics, antidepressants, sedative drugs or anxiolytics, and antiepileptic drugs are typically prescribed. However, such management of BPSD can be complicated by hypersensitivity to antipsychotic drugs, as observed in DLB, and a lack of effective pro-cognitive treatment in the case of frontotemporal dementia. The present paper reviews current knowledge of the management of BPSD and its limitations and discusses on-going clinical trials and future therapeutic options.

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“…There is also research exploring the impacts of tDCS on negative symptoms ( Osoegawa et al, 2018 ; Pontillo et al, 2018 ). Previous work has examined negative symptoms in conjunction with positive symptoms such as auditory hallucinations, also targeting the DLPFC ( Brunelin et al, 2012 ; Fröhlich et al, 2016 ).…”

Section: Studies Evaluating the Efficacy Of Tdcs On Influencing Clinimentioning

confidence: 99%

“…To date, there are informative reviews investigating the impacts of tDCS on schizophrenia populations (e.g., Brunoni et al, 2014 ; Fregni et al, 2015 ; Fröhlich et al, 2015 ; Kadosh, 2015 ; Mondino et al, 2015 ) and more recent reviews discussing tDCS and symptoms ( Osoegawa et al, 2018 ; Pontillo et al, 2018 ). However, there have been several new tDCS studies conducted which are summarized in the current review.…”

Section: Introductionmentioning

confidence: 99%

Transcranial Direct Current Stimulation, Symptomatology, and Cognition in Psychosis: A Qualitative Review

Gupta

Kelley

Pelletier-Baldelli

et al. 2018

Front. Behav. Neurosci.

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Schizophrenia is a chronic, debilitating condition that affects approximately 1% of the population. Individuals diagnosed with schizophrenia typically exhibit positive (e.g., hallucinations) and negative symptoms (e.g., anhedonia) and impairments in cognitive function. Given the limitations of antipsychotic medication and psychotherapy in fully treating psychosis symptomatology, there has been increasing interest in other interventions such as transcranial direct current stimulation (tDCS). tDCS is a non-invasive neuromodulation technique, that is safe, cost-effective, and widely accessible. Here, we discuss treatment studies that seek to improve symptoms and cognitive performance in schizophrenia using tDCS. Currently within the literature, there is support for reductions in positive symptoms such as hallucinations after receiving tDCS. Further, studies indicate that tDCS can improve cognitive functioning, which is an area of investigation that is sorely needed, as it is unclear which types of interventions may be useful in ameliorating cognitive deficits among this group. Taken together, the evidence suggests that tDCS holds promise in improving symptoms and cognition. To that end, tDCS has critical clinical implications for this population.

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Non-invasive brain stimulation for negative symptoms in schizophrenia: An updated systematic review and meta-analysis

Cited by 83 publications

References 55 publications

Motor cortical plasticity in schizophrenia: A meta-analysis of Transcranial Magnetic Stimulation – Electromyography studies

Motor cortical plasticity in schizophrenia: A meta-analysis of Transcranial Magnetic Stimulation – Electromyography studies

Pharmacotherapy of Behavioral and Psychological Symptoms of Dementia: State of the Art and Future Progress

Transcranial Direct Current Stimulation, Symptomatology, and Cognition in Psychosis: A Qualitative Review

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