Transcranial Direct Current Stimulation, Symptomatology, and Cognition in Psychosis: A Qualitative Review

Gupta, Tina; Kelley, Nicholas J.; Pelletier-Baldelli, Andrea; Mittal, Vijay A.

doi:10.3389/fnbeh.2018.00094

Cited by 22 publications

(15 citation statements)

References 74 publications

(145 reference statements)

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“…tDCS has been used to improve functioning in patients with SSD in multiple tasks ( Chang et al , 2018 ; Gupta et al , 2018 ; Kennedy et al , 2018 ; Lee et al , 2018 ; Mellin et al , 2018 ; Mondino et al , 2018 ; Morgan and Singh, 2018 ; Sreeraj et al , 2018 ; Schülke and Straube, 2019 ); however, its effects on action-outcome monitoring have hitherto remained unexplored. Here, we provide some first insights into the effect of tDCS on the temporal prediction or monitoring of voluntary action outcomes in patients with SSD.…”

Section: Discussionmentioning

confidence: 99%

“…Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique increasingly used for modulation of central nervous system excitability in humans (see Woods et al , 2016 , for a review). Furthermore, the use of tDCS has been shown to improve performance in various tasks and can reduce symptoms in patients with schizophrenia (for reviews, see Gupta et al , 2018 ; Kennedy et al , 2018 ; Lee et al , 2018 ; Kostova et al , 2020 ). One general assumption is that anodal tDCS increases cortico-spinal excitability and cathodal tDCS decreases it ( Nitsche and Paulus, 2000 ).…”

Section: Introductionmentioning

confidence: 99%

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Transcranial direct current stimulation improves action-outcome monitoring in schizophrenia spectrum disorder

Straube

Kemenade

Kircher

et al. 2020

Brain Communications

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Patients with schizophrenia spectrum disorder often demonstrate impairments in action-outcome monitoring. Passivity phenomena and hallucinations, in particular, have been related to impairments of efference copy-based predictions which are relevant for the monitoring of outcomes produced by voluntary action. Frontal transcranial direct current stimulation has been shown to improve action-outcome monitoring in healthy subjects. However, whether transcranial direct current stimulation can improve action monitoring in patients with schizophrenia spectrum disorder remains unknown. We investigated whether transcranial direct current stimulation can improve the detection of temporal action-outcome discrepancies in patients with schizophrenia spectrum disorder. On 4 separate days, we applied sham or left cathodal/right anodal transcranial direct current stimulation in a randomised order to frontal (F3/F4), parietal (CP3/CP4) and frontoparietal (F3/CP4) areas of 19 patients with schizophrenia spectrum disorder and 26 healthy control subjects. Action-outcome monitoring was assessed subsequent to 10 min of sham/transcranial direct current stimulation (1.5 mA). After a self-generated (active) or externally generated (passive) key press, subjects were presented with a visual outcome (a dot on the screen), which was presented after various delays (0–417 ms). Participants had to detect delays between the key press and the visual consequence. Symptom subgroups were explored based on the presence or absence of symptoms related to a paranoid-hallucinatory syndrome. In general, delay-detection performance was impaired in the schizophrenia spectrum disorder compared to the healthy control group. Interaction analyses showed group-specific (schizophrenia spectrum disorder vs healthy control group) and symptom-specific (with/without relevant paranoid-hallucinatory symptoms) transcranial direct current stimulation effects. Post-hoc tests revealed that frontal transcranial direct current stimulation improved the detection of long delays in active conditions and reduced the proportion of false alarms in undelayed trials of the passive condition in patients. The patients with no or few paranoid-hallucinatory symptoms benefited especially from frontal transcranial direct current stimulation in active conditions, while improvement in the patients with paranoid-hallucinatory symptoms was predominantly reflected in reduced false alarm rates in passive conditions. These data provide some first evidence for the potential utility of transcranial direct current stimulation in improving efference copy mechanisms and action-outcome monitoring in schizophrenia spectrum disorder. Current data indicate that improving efference copy-related processes can be especially effective in patients with no or few positive symptoms, while intersensory matching (i.e. task-relevant in passive conditions) could be more susceptible to improvement in patients with paranoid-hallucinatory symptoms.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Transcranial direct current stimulation improves action-outcome monitoring in schizophrenia spectrum disorder

Straube

Kemenade

Kircher

et al. 2020

Brain Communications

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“…These encouraging findings have led to a few small pilot studies which found that the combination of cognitive remediation plus aerobic exercise leads to differential improvement for some aspects of cognition and functioning. Similarly, based on findings that transcranial direct current stimulation (tDCS) may improve selected aspects of cognition in schizophrenia, a few small pilot studies have reported differential benefits of brief cognitive remediation plus tDCS (versus sham) interventions on trained cognitive tasks.…”

Section: Interventions For Cognitive Impairmentsmentioning

confidence: 99%

Nonsocial and social cognition in schizophrenia: current evidence and future directions

2019

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Cognitive impairment in schizophrenia involves a broad array of nonsocial and social cognitive domains. It is a core feature of the illness, and one with substantial implications for treatment and prognosis. Our understanding of the causes, consequences and interventions for cognitive impairment in schizophrenia has grown substantially in recent years. Here we review a range of topics, including: a) the types of nonsocial cognitive, social cognitive, and perceptual deficits in schizophrenia; b) how deficits in schizophrenia are similar or different from those in other disorders; c) cognitive impairments in the prodromal period and over the lifespan in schizophrenia; d) neuroimaging of the neural substrates of nonsocial and social cognition, and e) relationships of nonsocial and social cognition to functional outcome. The paper also reviews the considerable efforts that have been directed to improve cognitive impairments in schizophrenia through novel psychopharmacology, cognitive remediation, social cognitive training, and alternative approaches. In the final section, we consider areas that are emerging and have the potential to provide future insights, including the interface of motivation and cognition, the influence of childhood adversity, metacognition, the role of neuroinflammation, computational modelling, the application of remote digital technology, and novel methods to evaluate brain network organization. The study of cognitive impairment has provided a way to approach, examine and comprehend a wide range of features of schizophrenia, and it may ultimately affect how we define and diagnose this complex disorder.

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“…Therefore, we aimed to examine the effects of tDCS on the left posterior temporal cortex, thereby targeting the auditory cortex excitability, in more detail. The effectiveness of tDCS on processing in the AC is particularly interesting in the context of tDCS as a potential treatment option for electrophysiological parameters and symptoms of psychiatric diseases, e.g., lower N100 or auditory verbal hallucinations in schizophrenia ( Ford et al, 2001a , b , c , d ; Hubl et al, 2007 ; Li et al, 2016 ; Ponde et al, 2017 ; Gupta et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

No Effect of Transcranial Direct Current Stimulation of the Auditory Cortex on Auditory-Evoked Potentials

Kunzelmann¹,

Meier²,

Grieder³

et al. 2018

Front. Neurosci.

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Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique to change cortical excitability. Its effects are shown for cognitive processing, and behavior in the motor and perceptual domains. However, evidence of tDCS effects in the perceptual domain particularly for auditory processing is rare. Therefore, and in the context of disturbances in auditory processing in psychiatric populations, e.g., in patients with auditory verbal hallucinations, we aimed to investigate the potential modulatory effect of tDCS on the excitability of left posterior temporal cortex in detail. We included 24 healthy participants in a crossover design, applying sham and anodal stimulation in two measurement sessions 1 week apart. Electroencephalography (EEG) was recorded while participants listened to tones before, during, and after stimulation. Amplitudes and latencies of P50, N100, and P200 auditory-evoked potentials (AEP) were compared between anodal and sham stimulation, and between time points before, during, and after tDCS. In contrast to previous studies, results demonstrate no significant differences between stimulation types or time points for any of the investigated AEP amplitudes or latencies. Furthermore, a topographical analysis did not show any topographical differences during peak time periods of the investigated AEP for stimulation types and time points besides a habituation effect. Thus, our results suggest that tDCS modulation of excitability of the left posterior temporal cortex, targeting the auditory cortex, does not have any effect on AEP. This is particularly interesting in the context of tDCS as a potential treatment for changed electrophysiological parameters and symptoms of psychiatric diseases, e.g., lower N100 or auditory verbal hallucinations in schizophrenia.

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Transcranial Direct Current Stimulation, Symptomatology, and Cognition in Psychosis: A Qualitative Review

Cited by 22 publications

References 74 publications

Transcranial direct current stimulation improves action-outcome monitoring in schizophrenia spectrum disorder

Transcranial direct current stimulation improves action-outcome monitoring in schizophrenia spectrum disorder

Nonsocial and social cognition in schizophrenia: current evidence and future directions

No Effect of Transcranial Direct Current Stimulation of the Auditory Cortex on Auditory-Evoked Potentials

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