Non-invasive Brain Stimulation Therapy in Multiple Sclerosis: A Review of tDCS, rTMS and ECT Results

Palm, Ulrich; Ayache, Samar S.; Padberg, Frank; Lefaucheur, Jean‐Pascal

doi:10.1016/j.brs.2014.09.014

Cited by 66 publications

(65 citation statements)

References 54 publications

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“…Since this discovery, important progress has been made in tDCS field and this intervention has been introduced in human studies over the last 15 years [146]. tDCS application has yielded encouraging results in many neuropsychiatric disorders, like refractory major depression, chronic neuropathic pain, stroke, and MS, to cite a few [114,152]. Consequently, scientific awareness has been particularly raised to determine the place of this promising method in the treatment of MS fatigue.…”

Section: Non Invasive Brain Stimulationmentioning

confidence: 96%

“…As stated above, TMS concept is based on a known physical principle of the Evaluation and management of MS fatigue 21 the left DLPFC, respectively [113,143]. Concerning MS, rTMS has been tried to alleviate a number of MS-related symptoms such as pain, spasticity and urinary disturbances [152]. However, no rTMS study has been conducted in the context of MS fatigue, and the beneficial effects of this method are yet to be determined.…”

Section: Non Invasive Brain Stimulationmentioning

confidence: 98%

“…Therefore, combining pharmacological and alternative therapies would be the key toward an optimal management plan. A variety of alternative therapies has been assessed in this setting such as exercise [84], cognitive behavioral therapies [232], cryostimulation [130], and noninvasive brain stimulation (NIBS) [24,152] -and the list goes on. For the sake of this review, we will only focus on NIBS techniques.…”

Section: Alternative Therapiesmentioning

confidence: 99%

See 2 more Smart Citations

Fatigue in multiple sclerosis – Insights into evaluation and management

Ayache

Chalah

2017

Neurophysiologie Clinique/Clinical Neurophysiology

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129

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Section: Non Invasive Brain Stimulationmentioning

confidence: 96%

Section: Non Invasive Brain Stimulationmentioning

confidence: 98%

Section: Alternative Therapiesmentioning

confidence: 99%

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Fatigue in multiple sclerosis – Insights into evaluation and management

Ayache

Chalah

2017

Neurophysiologie Clinique/Clinical Neurophysiology

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129

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“…Transcranial direct current stimulation (tDCS) is a relatively recent therapeutic development that utilizes low amplitude direct current (2.0 mA) to induce changes in cortical excitability (1)(2)(3)(4). tDCS is known to be safe and well-tolerated (5)(6)(7)(8) with many advantages compared to other stimulation methods including ease of use, lower cost, and portability (9). It is theorized that pairing tDCS with rehabilitation strategies may lead to more meaningful and lasting benefit (10)(11)(12)(13)(14).…”

Section: Introductionmentioning

confidence: 99%

“…The most common subtype is relapsing-remitting and over half of these individuals transition to a progressive course; the remainder have a progressive course from the onset (31). tDCS warrants evaluation for potential clinical applications in MS (9,21,(32)(33)(34)(35)(36)(37)(38)(39). MS is associated with a high (>70%) rate of cognitive impairment.…”

Section: Introductionmentioning

confidence: 99%

Remotely Supervised Transcranial Direct Current Stimulation Increases the Benefit of At-Home Cognitive Training in Multiple Sclerosis

Charvet

Shaw

Dobbs

et al. 2018

Neuromodulation: Technology at the Neural Interface

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Objective To explore the efficacy of remotely-supervised transcranial direct current stimulation (RS-tDCS) paired with cognitive training (CT) exercise in participants with multiple sclerosis (MS). Methods In a feasibility study of RS-tDCS in MS, participants completed ten sessions of tDCS paired with CT (1.5 mA × 20 min, dorsolateral prefrontal cortex montage). RS-tDCS participants were compared to a control group of adults with MS who underwent ten 20-min CT sessions through the same remotely supervised procedures. Cognitive outcomes were tested by composite scores measuring change in performance on standard tests (Brief International Cognitive Assessment in MS or BICAMS), basic attention (ANT-I Orienting and Attention Networks, Cogstate Detection), complex attention (ANT-I Executive Network, Cogstate Identification and One-Back), and intra-individual response variability (ANT-I and Cogstate identification; sensitive markers of disease status). Results After ten sessions, the tDCS group (n = 25) compared to the CT only group (n = 20) had significantly greater improvement in complex attention (p = 0.01) and response variability (p = 0.01) composites. The groups did not differ in measures of basic attention (p =0.95) or standard cognitive measures (p = 0.99). Conclusions These initial findings indicate benefit for RS-tDCS paired with CT in MS. Exploratory analyses indicate that the earliest tDCS cognitive benefit is seen in complex attention and response variability. Telerehabilitation using RS-tDCS combined with CT may lead to improved outcomes in MS.

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Transcranial direct current stimulation for fatigue in neurological conditions: A systematic scoping review

Jagadish,

Shankaranarayana,

Natarajan

et al. 2023

Physiotherapy Res Intl

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Background and PurposeFatigue following neurological conditions negatively impacts daily activities, reducing overall quality of life. Transcranial direct current stimulation (tDCS) for fatigue management is still underexplored. This scoping review explores its use in managing fatigue among various neurological conditions.MethodsA thorough literature search was carried out using PubMed, Scopus, CINAHL, Web of Science, Embase, ProQuest, and the Cochrane Library. Google Scholar and clinicaltrials.gov were manually searched for gray literature and ongoing trials, respectively. Regardless of the study design, all studies utilizing tDCS for the management of fatigue in various neurological conditions were considered. Two reviewers independently screened all the studies, following which the data were retrieved.ResultsStudies employing tDCS for fatigue management across neurological conditions is as follows: Multiple sclerosis (MS) (n = 28, 66%), stroke (n = 5, 12%), Parkinson's disease (PD) (n = 4, 10%), post‐polio syndrome (PPS) (n = 2, 5%), traumatic brain injury (TBI) (n = 2, 5%), and amyotrophic lateral sclerosis (n = 1, 2%). All the studies used anodal stimulation, with the common stimulation site being the left dorsolateral prefrontal cortex for MS, stroke, and PD. A stimulation intensity of 1.0–4.0 mA with a duration ranging from 15 to 30 min in 1 to 24 sessions were commonly reported. The Fatigue Severity Scale (n = 21) and Modified Fatigue Impact Scale (n = 17) were frequently implemented outcome measures. Regardless of the study design, 36/42 (85.7%) studies reported an improvement in fatigue scores in the tDCS group. The common adverse events noted were tingling (n = 8, 35%), headache (n = 6, 26%), and itching (n = 6, 26%).DiscussionApplication of tDCS for fatigue was explored in individuals with stroke, PD, PPS, and TBI after MS. Even though a wide range of treatment parameters and outcome measures were adopted to assess and target fatigue, tDCS proves to have a promising role in alleviating this symptom.

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Non-invasive Brain Stimulation Therapy in Multiple Sclerosis: A Review of tDCS, rTMS and ECT Results

Cited by 66 publications

References 54 publications

Fatigue in multiple sclerosis – Insights into evaluation and management

Fatigue in multiple sclerosis – Insights into evaluation and management

Remotely Supervised Transcranial Direct Current Stimulation Increases the Benefit of At-Home Cognitive Training in Multiple Sclerosis

Transcranial direct current stimulation for fatigue in neurological conditions: A systematic scoping review

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