Non-Invasive Breast Cancer Diagnosis through Electrochemical Biosensing at Different Molecular Levels

Campuzano, Susana; Pedrero, Marı́a; Pingarrón, José M.

doi:10.3390/s17091993

Cited by 47 publications

(12 citation statements)

References 55 publications

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“…Electrochemical biosensors of biochemical affinity study specific biological recognition interactions such as antigen-antibody binding and nucleic acid hybridization reactions, primarily triggering a measurable electrochemical response (Figure 1). These electrochemical biosensors are usually the most used in the detection of a large number of biomolecules of clinical relevance due to their high specificity [68].…”

Section: Nanobioengineered Electrochemical Biosensorsmentioning

confidence: 99%

Electrochemical Biosensors for Determination of Colorectal Tumor Biomarkers

et al. 2020

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The accurate determination of specific tumor markers associated with cancer with non-invasive or minimally invasive procedures is the most promising approach to improve the long-term survival of cancer patients and fight against the high incidence and mortality of this disease. Quantification of biomarkers at different stages of the disease can lead to an appropriate and instantaneous therapeutic action. In this context, the determination of biomarkers by electrochemical biosensors is at the forefront of cancer diagnosis research because of their unique features such as their versatility, fast response, accurate quantification, and amenability for multiplexing and miniaturization. In this review, after briefly discussing the relevant aspects and current challenges in the determination of colorectal tumor markers, it will critically summarize the development of electrochemical biosensors to date to this aim, highlighting the enormous potential of these devices to be incorporated into the clinical practice. Finally, it will focus on the remaining challenges and opportunities to bring electrochemical biosensors to the point-of-care testing.

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Section: Nanobioengineered Electrochemical Biosensorsmentioning

confidence: 99%

Electrochemical Biosensors for Determination of Colorectal Tumor Biomarkers

et al. 2020

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“…Alternatively, electrochemical immunosensors allows simultaneous determination of different analytes, e.g., using multi-electrode arrays, with versatility, simplicity, quickness and under a wide range of concentrations [18,19]. Definitively, voltammetric immunosensors are among the most promising and interesting biosensors.…”

Section: Voltammetric Immunosensorsmentioning

confidence: 99%

“…MBs can help in lowering the detection limit, since they comprise a large surface area to immobilize biomolecules. They allow a fast and efficient purification and pre-concentration of the analyte contained in crude samples, eliminating the pretreatment or clean up steps [19,42]. In this sense, MBs have been widely used for the construction of immunosensors to improve the sensitivity and selectivity of the analytical methods, and minimize interferences from the matrix of complex samples.…”

Section: Screen-printed Electrodes (Spes) For Voltammetric Immunosmentioning

confidence: 99%

Disposable Voltammetric Immunosensors Integrated with Microfluidic Platforms for Biomedical, Agricultural and Food Analyses: A Review

Felix

Baccaro

Angnes

2018

Sensors

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Disposable immunosensors are analytical devices used for the quantification of a broad variety of analytes in different areas such as clinical, environmental, agricultural and food quality management. They detect the analytes by means of the strong interactions between antibodies and antigens, which provide concentration-dependent signals. For the herein highlighted voltammetric immunosensors, the analytical measurements are due to changes in the electrical signals on the surface of the transducers. The possibility of using disposable and miniaturized immunoassays is a very interesting alternative for voltammetric analyses, mainly, when associated with screen-printing technologies (screen-printed electrodes, SPEs), and microfluidic platforms. The aim of this paper is to discuss a carefully selected literature about different examples of SPEs-based immunosensors associated with microfluidic technologies for diseases, food, agricultural and environmental analysis. Technological aspects of the development of the voltammetric immunoassays such as the signal amplification, construction of paper-based microfluidic platforms and the utilization of microfluidic devices for point-of-care testing will be presented as well.

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“…For cancer-related mortality in women, breast cancer is one of the foremost reason. Eventhough, screening with mammography is widely used in clinical diagnosis, the prognosis still remains a challenge [4] [5].…”

Section: Introductionmentioning

confidence: 99%

Detection of Malignant Tissue using Metal Dielectric Interface Based Plasmonic Biosensor

2019

IJITEE

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Metal-dielectric interface based Plasmonic biosensors commonly known as Surface Plasmonic Resonance (SPR) used in numerous applications in the analysis of bio reagents interaction and detection of the biological pathogen, cells and provides the advantage of real-time label-free efficient method. Sensitivity is a key parameter to measure sensor performance during development. Among all the plasmonic configurations, waveguide coupled configuration is most effective. In such a configuration an SPR and a waveguide are coupled through an evanescent field. This provides superior control over the biological reagent interaction, greater sensitivity and a multichannel-robust sensing device. Such devices are very small in size, lightweight as compared to prism coupled configuration which is bulky. These devices are also equipped to segregate specific sensor responses from non-specific response simultaneous multi analytes analysis. In view of the aforesaid benefits of waveguide coupled SPR, our present work focuses on a dual channel integrated optical waveguide based on metal dielectric interface biosensor. To study the behaviour of a waveguide coupled SPR sensor, we carried out analysis and simulation of SPR on multilayer geometries using tumourassociated antigens (TAAs). First, we started with the analysis of an SPR in the multi-layer intersection and observed the effect of variation of material characteristics on SPR profile. Further, extended our investigation to multilayered optical waveguide and the propagation constant was calculated. TAA and Newton’s method were used for Lung Cancer and Breast Cancer infected tissue and sensitivity 300nm/RIU obtained.

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Non-Invasive Breast Cancer Diagnosis through Electrochemical Biosensing at Different Molecular Levels

Cited by 47 publications

References 55 publications

Electrochemical Biosensors for Determination of Colorectal Tumor Biomarkers

Electrochemical Biosensors for Determination of Colorectal Tumor Biomarkers

Disposable Voltammetric Immunosensors Integrated with Microfluidic Platforms for Biomedical, Agricultural and Food Analyses: A Review

Detection of Malignant Tissue using Metal Dielectric Interface Based Plasmonic Biosensor

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