Non-invasive control of influence of polyethylene glycol on transport function of fluorescent colored liposomal nanoparticles

Stelmashchuk, Olga; Zherebtsov, Evgeny; Zherebtsova, Angelina I.; Kuznetsova, Еlena; Vinokurov, Andrey Y.; Dunaev, Andrey V.; Mamoshin, Andrian; Снимщикова, И. А.; Борсуков, А. В.; Bykov, Alexander; Meglinski, Igor

doi:10.1117/12.2269379

Cited by 1 publication

(2 citation statements)

References 19 publications

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“…The similar result by the same probe was obtained by the authors for liposomal particles in previous studies. 8,9 The diagnostic volume and depth for the fluorescence measurements for the different excitation wavelengths for the fiber optical probe were also assessed by the Monte Carlo modelling previously. 16 Based on the results of the study, it was found that the nanocapsules contribute to the distribution and accumulation of the dye in tissue.…”

Section: Resultsmentioning

confidence: 99%

“…The diagnostic approach has considerable potential for drug discovery, not only during the development of a new drug formula but also in preclinical and clinical trials. 8,9 Optical methods, in particular, fluorescent spectroscopy, are promising tools for diagnostics in the modern medical practice as well 10 . Another vibrant area of modern study is targeted delivery of medicines, which can significantly improve the effectiveness of treatment of various diseases, reduce the occurrence of possible adverse side effects and disease complications.…”

Section: Introductionmentioning

confidence: 99%

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Noninvasive control of rhodamine-loaded capsules distribution in vivo

Stelmashchuk

Tarakanchikova

Seryogina³

et al. 2018

Saratov Fall Meeting 2017: Optical Technologies in Biophysics and Medicine XIX

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Using fluorescence spectroscopy system with the fibre-optical probe, we investigated the dynamics of propagation and circulation in the microcirculatory system of experimental nanocapsules fluorescent-labelled (rhodamine TRITC) nanocapsules. The studies were carried out in clinically healthy Wistar rats. The model animals were divided into control group, and the group received injections of the nanocapsules. The fluorescent measurements conducted transcutaneously on the thigh surface. The administration of the preparation with the rhodamine concentration of 5 mg/kg of animal weight resulted in a twofold increase of fluorescence intensity by reference to the baseline level. As a result of the study, it was concluded that fluorescence spectroscopy can be used for transdermal measurements of the rhodamine-loaded capsules in vivo.Keywords: nanocomposite polymeric capsules, fluorescent labelled particles, rhodamine TRITC, drug delivery, fluorescence spectroscopy, blood microcirculation, optical measurements in vivo 1. * o.a.stelmashuk@gmail.com; phone +7 919 269 79 92; www.bmecenter.ru/en/fluorescence_spectroscopy_in_vivo

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Section: Resultsmentioning

confidence: 99%