Non-invasive detection of osteoporotic bone loss using photothermal radiometry and modulated luminescence

Kwan, Chi-Hang; Matvienko, Anna; Mandelis, Andreas

doi:10.1117/12.763844

Cited by 3 publications

(5 citation statements)

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“…Medical and nondestructive testing applications of pulsed and continuously modulated ͑frequency-domain͒ photothermal radiometry methods ͑PPTR and FDPTR, respec-tively͒ have been the topic of many studies since the early 1980s. [1][2][3][4][5][6][7][8][9] PPTR ͑Ref. 3͒ uses short duration excitation sources with relatively high peak power while FDPTR ͑henceforth denoted simply by PTR͒ 1,2,4 incorporates low energy excitation sources with long duty cycles.…”

Section: Introductionmentioning

confidence: 99%

“…5 However, in the last decade, many efforts have been made to investigate the medical applications of PTR. [6][7][8][9] Mandelis and co-workers 6,7 were first to apply PTR to the detection of human dental demineralization lesions and defects. They were able to detect carious lesions in dentin and enamel fissures.…”

Section: Introductionmentioning

confidence: 99%

“…They were able to detect carious lesions in dentin and enamel fissures. Recently, preliminary results by Kwan et al 8 indicated that PTR also has the potential to detect osteoporotic bone loss. The most important drawback of medical PTR is its limited depth detection range.…”

Section: Introductionmentioning

confidence: 99%

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Thermal-wave radar: A novel subsurface imaging modality with extended depth-resolution dynamic range

Tabatabaei¹,

Mandelis²

2009

Review of Scientific Instruments

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126

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Combining the ideas behind linear frequency modulated continuous wave radars and frequency domain photothermal radiometry (PTR), a novel PTR method is introduced. Analytical solutions to the heat diffusion problem for both opaque and transparent solids are provided. Simulations and experimental results suggest a significant improvement in the dynamic range when using the thermal-wave radar (TWR) instead of conventional PTR. A practical TWR image resolution augmentation method is proposed.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Thermal-wave radar: A novel subsurface imaging modality with extended depth-resolution dynamic range

Tabatabaei¹,

Mandelis²

2009

Review of Scientific Instruments

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126

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“…Modulated luminescence (LUM) of hard tissues is a method which is based on direct near-infrared radiative photon emissions from chromophores responding to optical excitation. Our preliminary measurements on human cranial vault (skull) bones 12 have revealed strong luminescence emission with modulation frequency dependence very similar to that exhibited by dental enamel luminescence characteristic of hydroxyapatite. 13 LUM signals can subsequently be linked to intrinsic bone photophysical properties.…”

Section: Introductionmentioning

confidence: 84%

“…is the average of the excitation and decay coupling coefficients between the lower and upper energy states, E 1 and E 2 , of the endogenous chromophore participating in the optical interaction in the form of optical absorption (B 12 ) and luminescence emission (B 21 ) events, respectively.…”

Section: Theoretical Modelmentioning

confidence: 99%

Dynamic photophysical processes in laser irradiated human cortical skull bone

Mandelis

Kwan

Matvienko

2009

Optics in Bone Biology and Diagnostics

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Modulated luminescence (LUM) technique was applied to analyze photophysical processes in the cortical layer of human skull bones. The theoretical interpretation of the results was based on the optical excitation and decay rate equations of the fluorophore and on the molecular interaction parameter with the photon field density in the matrix of the bone. Using comparisons of the theory with the frequency response of dental LUM it was concluded that the optically active molecular species (fluorophore) in the bones is hydroxyapatite. An effective relaxation lifetime  of skull cortical bone was derived theoretically and was found to depend on the intrinsic fluorophore decay lifetime, on the photon field density, and on the thickness of the bone. The experimentally measured dependencies were in excellent agreement with the theoretical model. The theory was able to yield measurements of the optical scattering coefficient, optical absorption coefficient, and mean coupling coefficient. These results show that the quantitative LUM can be used as a sensitive method to measure optical properties of the active fluorophore in cortical skull bones and the optical-field-induced molecular interaction parameter. When calibrated vs. laser intensity, the modulated luminescence can also be used to measure human skull thickness. These traits can be applied to monitor the bone mineral density (BMD) and, ultimately can be used as potential markers of bone health or disease, such as osteoporosis or bone cancer.

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Optoelectronic tuning of two-dimensional engineered nanomaterials for enhanced photothermal therapy: opportunities and challenges

Osanloo,

Mohammadi,

Shahedi

et al. 2024

Graphene and 2D mater

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Non-invasive detection of osteoporotic bone loss using photothermal radiometry and modulated luminescence

Cited by 3 publications

References 0 publications

Thermal-wave radar: A novel subsurface imaging modality with extended depth-resolution dynamic range

Thermal-wave radar: A novel subsurface imaging modality with extended depth-resolution dynamic range

Dynamic photophysical processes in laser irradiated human cortical skull bone

Optoelectronic tuning of two-dimensional engineered nanomaterials for enhanced photothermal therapy: opportunities and challenges

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