Non-invasive in vitro sensing of d-glucose in pig blood

Melikyan, Harutyun; Danielyan, Emma; Kim, Seungwan; Kim, Jongchel; Babajanyan, Arsen; Lee, Jungha; Friedman, Barry; Lee, Kiejin

doi:10.1016/j.medengphy.2011.07.020

Cited by 39 publications

(27 citation statements)

References 21 publications

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“…In vitro studies have been conducted, using various types of sensors with various solutions: a sensor based on a rectangular MS patch antenna with both physiological saline-glucose as well as pig blood-glucose solutions in [12], an MS TL section with aqueous-and blood-glucose solutions in [13], waveguide with a goat blood-glucose solution in [14], a spiral MS resonator with blood phantom in [15] and with pig blood in [16].…”

Section: Introductionmentioning

confidence: 99%

A Microwave Metamaterial Inspired Sensor for Non-Invasive Blood Glucose Monitoring

Vrba¹,

Vrba²

2015

RADIOENGINEERING

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Section: Introductionmentioning

confidence: 99%

A Microwave Metamaterial Inspired Sensor for Non-Invasive Blood Glucose Monitoring

Vrba¹,

Vrba²

2015

RADIOENGINEERING

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“…On the other hand, the complex dielectric permittivity of solution depending on solute (glucose) concentration is given by ε g (ω) = [ε 0 (ω) + cδ ]−j[ε 0 (ω) + cδ where ε 0 (ω) is the complex permittivity of DI water (ε 0 (ω) = 73.89 and ε 0 (ω) = 21.55 at 6 GHz, 25 • C), c is the concentration of glucose, and δ is the increase in permittivity when the glucose concentration is raised by 1 unit (δ = 0.00577 (mg/dL)−1 and δ = 0.00015 (mg/dL)−1) [18,19]. Here the complex dielectric permittivity of DI water is giving by the Cole-Cole relaxation model…”

Section: Theoretical Backgroundmentioning

confidence: 99%

Real-Time Noninvasive Measurement of Glucose Concentration Using a Modified Hilbert Shaped Microwave Sensor

Odabashyan

Babajanyan

Baghdasaryan

et al. 2019

Sensors

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We developed a microwave glucose sensor based on the modified first-order Hilbert curve design and measured glucose concentration in aqueous solutions by using a real-time microwave near-field electromagnetic interaction technique. We observed S 21 transmission parameters of the sensor at resonant frequencies depend on the glucose concentration. We could determine the glucose concentration in the 0-250 mg/dL concentration range at an operating frequency of near 6 GHz. The measured minimum detectable signal was 0.0156 dB/(mg/dL) and the measured minimum detectable concentration was 1.92 mg/dL. The simulation result for the minimum detectable signal and the minimum detectable concentration was 0.0182 dB/(mg/dL) and 1.65 mg/dL, respectively. The temperature instability of the sensor for human glycemia in situ measurement range (27-34 • C for fingers and 36-40 • C for body temperature ranges) can be improved by the integration of the temperature sensor in the microwave stripline platform and the obtained data can be corrected during signal processing. The microwave signal-temperature dependence is almost linear with the same slope for a glucose concentration range of 50-150 mg/dL. The temperature correlation coefficient is 0.05 dB/ • C and 0.15 dB/ • C in 27-34 • C and 36-40 • C temperature range, respectively. The presented system has a cheap, easy fabrication process and has great potential for non-invasive glucose monitoring.

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“…There is currently no FDA approved noninvasive glucometer on the United States market but such a device would result in less patient discomfort and the ability to more closely monitor the glucose levels of affected individuals leading to better preventative care. The ability to non-invasively detect glucose has been explored using optical methods [12], impedance spectroscopy [13], open waveguides [14], and a spiral resonator [15]. Figure 15: Results of testing all the different structures as sensors for glucose-d. For each structure the main resonant peak is focused on so that the change due to the different concentrations of glucose-d can be more easily observed.…”

Section: Biosensing Applicationmentioning

confidence: 99%

Metamaterial inspired periodic structure used for microfluidic sensing

Byford

Park

Chahal

2015

2015 IEEE 65th Electronic Components and Technology Conference (ECTC)

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A novel metamaterial inspired resonating structure coupled with a microfluidic channel has been evaluated for sensing applications in the microwave frequency range. The structure is based on an open split ring resonator (OSRR) design, was simulated in a finite element analysis tool (Ansys HFSS R ) and tested using a Vector Network Analyzer to detect changes in resonant frequency, amplitude, and phase due to dielectric loading from different chemicals in the microfluidic channel. The sensor was tested as a single unit cell, in a three cell aperiodic array and as an array of three different frequencies. Different concentrations of water-isopropanol (IPA) and watermethanol were used to characterize the sensor. Additionally, a biosensor application was demonstrated in detecting glucose-d concentration in deionized water. BackgroundThere is a growing demand for inexpensive sensors that can effectively detect changes in material properties in extremely small samples of liquids. Applications range from biomedical devices, lab on chip devices, environmental monitoring and forensic investigations. Optical detection is considered the superior technology for use in microfluidic devices given its predominant use and well understood phenomena [1]. The key technologies from the optical perspective are absorbance detection, fluorescence detection, chemiluminescence detection, interferometric detection, and surface plasmon resonance detection. These approaches can be costly, require regular calibration and are limited in their ability to be miniaturized. Many of these approaches also rely on the use of "tagging", where fluorescent markers are used, which compromise the integrity of the chemical sample. Our approach to use a microstrip based microwave structure does not require calibration, does not require tagging, is simple and inexpensive to fabricate, and can easily be miniaturized.Microfluidic sensors in the microwave and radio frequency region have previously been demonstrated. The work described in [2] had a radio frequency device for sensing changes in small liquid samples that was transmission line based, the work in [3][4][5] use spiral based structures and show good sensitivity in the microwave region as well. Our approach requires a much less complicated design than the proposed system in [2] and has a few key advantages over the spiral based structures. Our structure has its electric field relatively concentrated in key areas on the designs surface meaning our microfluidic channel can be much simpler and smaller, thus requiring less fluid to get results. Our structure is also much smaller than the spiral based designs currently proposed and could be fur-

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Non-invasive in vitro sensing of d-glucose in pig blood

Cited by 39 publications

References 21 publications

A Microwave Metamaterial Inspired Sensor for Non-Invasive Blood Glucose Monitoring

A Microwave Metamaterial Inspired Sensor for Non-Invasive Blood Glucose Monitoring

Real-Time Noninvasive Measurement of Glucose Concentration Using a Modified Hilbert Shaped Microwave Sensor

Metamaterial inspired periodic structure used for microfluidic sensing

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