Non-invasive measurement of hemodynamic change during 8 MHz transcranial focused ultrasound stimulation using near-infrared spectroscopy

Kim, Evgenii; Anguluan, Eloise; Youn, Sangyeon; Kim, Jihun; Hwang, Jae Youn; Kim, Jae Gwan

doi:10.1186/s12868-019-0493-9

Cited by 17 publications

(12 citation statements)

References 41 publications

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“…DCS-diffuse correlation spectroscopy) and tissue oxygenation (static NIRS) (Hosomi et al, 2019;Hou et al, 2019). It is an attractive and accessible approach to investigate brain activity changes with its high temporal resolution, robustness to electrical artefacts, and low cost (Kim et al, 2019). The device measures relative changes in oxygenated-(oxy-), deoxygenated-(deoxy-) and total Hb concentrations, and oxygen saturation using different wavelengths (Hosomi et al, 2019;Hou et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Neuromonitoring During Cardiac Surgery in a Patient with Ventriculo-Caval Shunt Migration: Case Report

Leibuss

Babuškina

Žeņiļenko

et al. 2021

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

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Ventricular shunting is a well-recognised and commonly practiced method of reducing increased intracranial pressure in patients with neurologic pathology. There are possible complications related to shunt implantation, where the rarest is intracardiac migration of the distal shunt catheter. We present a case where the distal catheter migrated into the right ventricle, causing extrasystoles and was complicated with acute right ventricle failure during the endovascular shunt evacuation procedure.

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Section: Discussionmentioning

confidence: 99%

Neuromonitoring During Cardiac Surgery in a Patient with Ventriculo-Caval Shunt Migration: Case Report

Leibuss

Babuškina

Žeņiļenko

et al. 2021

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

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“…6. COMSOL 3-DIMENSIONAL ANALYSIS Studies using higher frequencies of 27.38 M H z and 8 M H z by [37] and [126] used intensities of I SP P A 0.465 W /cm 2 and I SP P A 12 and 5.2 W /cm 2 , respectively. Studies, using lower frequencies in general used higher intensities or pressures such as 1.76 M P a at 2 M H z by [29], I SP P A 34.96 W /cm 2 at 2.32 M H z by [127], I SP P A 46 W /cm 2 at 2 M H z by [128] and I SP P A of 8.93 W /cm 2 and pressure of 0.51 M P a at 2.9 M H z by [129].…”

Section: Comparison Between Simulation and Literaturementioning

confidence: 99%

Stent with Piezoelectric Transducers for High Spatial Resolution Ultrasound Neuromodulation- a Finite Element Analysis

Dilevicius

Serdijn

Costa

2022

2022 44th Annual International Conference of the IEEE Engineering in Medicine &Amp; Biology Society (EMBC)

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D EEP brain stimulation is currently the only technique used in the clinical setting, capable of stimulating the deep brain nuclei. Recently, low intensity focused ultrasound has been shown to reversibly modulate brain activity. At present, ultrasound neuromodulation is performed through the transcranial pathway. This requires the ultrasound waves to pass through the skull, thus attenuating the ultrasound waves. To reduce the effect of attenuation, lower frequencies are used of around 0.5 M H z, however, with decreasing frequency the focal region in which the stimulation occurs also increases. Therefore, a stent with an array of ultrasound transducers operating at high frequencies of around 5 M H z has been proposed to bypass the skull, thus significantly reducing the attenuation. Moreover, such a device would require a minimally invasive procedure removing the need for open brain surgery as currently performed for deep brain stimulation. This research was performed to evaluate the feasibility of using ultrasound arrays within the brain vasculature to stimulate deep brain nuclei using the finite element method.Initially, a literature review was conducted to identify the optimal ultrasound parameters for achieving neuromodulation. For stimulation, a PRF ranging from 500 to 1500 H z and a DC of around 50 to 70% were found to be optimal. Whereas for suppression, a PRF of<100 H z and a DC of around >=10% were found to be ideal. The intensity for both suppression and stimulation was found to greatly depends on the target region and individual as well as anaesthesia for stimulation, nonetheless, for 5 M H z an intensity of around 1 W /cm 2 was required to achieve neural excitation.Next, the brain nuclei were studied and the subthalamic nucleus, ventral intermediate nucleus and globus pallidus internus were identified to be the most commonly targeted nuclei for deep brain stimulation. Brain vasculature was then examined in terms of the blood vessel inner diameter, shape, orientation with respect to the nuclei and the distance to the nuclei. Basal vein of Rosenthal, internal cerebral vein and internal carotid artery were found to be most suitable to target the subthalamic nucleus, ventral intermediate nucleus and globus pallidus internus respectively.Afterwards, two-dimensional simulations were performed using COMSOL Multiphysics to identify the minimum required array width and length for stimulating each nucleus from its respective blood vessel. However, when compared to 3D counterparts it was found that 2D significantly overestimated the size of the focal region.Finally, 3D simulations of 100 x 100 x 262 µm transducers in a 104 (2D 26 x 4) and 105 (Checkered [3 x 2] x 21) arrays within the BVR were analysed targeting the STN. These arrays were found to produce a focal region of full width half intensity within the subthalamic nucleus model boundaries while reaching intensities and pressures of 0.558 W /cm 2 or 0.140 MPa and 0.311 W /cm 2 or 0.101 M P a with a 1 V terminal for 2D and checkered array respectively. Theref...

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“…Two studies examined the neuromodulation effect on the S1 with wide-field optical imaging (Choi et al, 2019) and near infrared spectroscopy (NIRS) measurements (Kim et al, 2019a). Both of the studies showed that neuronal calcium signaling was at least twice that observed in peripheral regions.…”

Section: Neuromodulatory Effect Of Tus In Animalsmentioning

confidence: 99%

Effect of Low Intensity Transcranial Ultrasound Stimulation on Neuromodulation in Animals and Humans: An Updated Systematic Review

et al. 2021

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Background: Although low-intensity transcranial ultrasound stimulation (LI-TUS) has received more recognition for its neuromodulation potential, there remains a crucial knowledge gap regarding the neuromodulatory effects of LI-TUS and its potential for translation as a therapeutic tool in humans.Objective: In this review, we summarized the findings reported by recently published studies regarding the effect of LI-TUS on neuromodulation in both animals and humans. We also aim to identify challenges and opportunities for the translation process.Methods: A literature search of PubMed, Medline, EMBASE, and Web of Science was performed from January 2019 to June 2020 with the following keywords and Boolean operators: [transcranial ultrasound OR transcranial focused ultrasound OR ultrasound stimulation] AND [neuromodulation]. The methodological quality of the animal studies was assessed by the SYRCLE's risk of bias tool, and the quality of human studies was evaluated by the PEDro score and the NIH quality assessment tool.Results: After applying the inclusion and exclusion criteria, a total of 26 manuscripts (24 animal studies and two human studies) out of 508 reports were included in this systematic review. Although both inhibitory (10 studies) and excitatory (16 studies) effects of LI-TUS were observed in animal studies, only inhibitory effects have been reported in primates (five studies) and human subjects (two studies). The ultrasonic parameters used in animal and human studies are different. The SYRCLE quality score ranged from 25 to 43%, with a majority of the low scores related to performance and detection bias. The two human studies received high PEDro scores (9/10).Conclusion: LI-TUS appears to be capable of targeting both superficial and deep cerebral structures to modulate cognitive or motor behavior in both animals and humans. Further human studies are needed to more precisely define the effective modulation parameters and thereby translate this brain modulatory tool into the clinic.

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Non-invasive measurement of hemodynamic change during 8 MHz transcranial focused ultrasound stimulation using near-infrared spectroscopy

Cited by 17 publications

References 41 publications

Neuromonitoring During Cardiac Surgery in a Patient with Ventriculo-Caval Shunt Migration: Case Report

Neuromonitoring During Cardiac Surgery in a Patient with Ventriculo-Caval Shunt Migration: Case Report

Stent with Piezoelectric Transducers for High Spatial Resolution Ultrasound Neuromodulation- a Finite Element Analysis

Effect of Low Intensity Transcranial Ultrasound Stimulation on Neuromodulation in Animals and Humans: An Updated Systematic Review

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