Two-phase gas-liquid and gas-dispersed flows are frequently encountered in the energy, nuclear, chemical, geothermal, oil and gas and refrigeration industries. Two-phase gas-liquid flows can occur in various forms, such as flows transitioning from pure liquid to vapor as a result of external heating, separated flows behind a flow's sudden expansion or constriction, dispersed two-phase flows where the dispersed phase is present in the form of liquid droplets, or gas bubbles in a continuous carrier fluid phase (i.e. gas or liquid). Typically, such flows are turbulent with a considerable interfacial interaction between the carrier fluid and the dispersed phases. The interfacial heat and mass transfer is very important in the modeling of such flows. The variety of flow regimes significantly complicates the theoretical prediction of hydrodynamics of the two-phase flow. It requires the application of numerous hypotheses, assumptions, and approximations. Often the complexity of flow structures makes it impossible to theoretically describe its behavior, and so empirical data are applied instead.The correct simulation of two-phase gas-liquid flows is of great importance for safety's sake and the prediction of energy equipment elements. This Special issue discusses papers related to various aspects of the hydrodynamics and heat mass transfer in two-phase gas-liquid and gas-dispersed flows in pipes or ducts. They can be used as well as in basic sciences and vast applications. Authors from Russia, China, the U.S.A., the U.K., India, and Singapore published their recent contributions for this Special Issue. We are happy to see that all papers present findings characterized as unconventional, innovative, and methodologically new. We hope that the readers of the journal Water can enjoy and learn about experimental and numerical study of two-phase flows using the published material and share the results with the other researchers. In total, 11 papers were presented in this Special Issue (2 of them are reviews and 9 papers are the article) and 3 papers from this list are feature papers.The main goals of this Special Issue are to present the recent advances in experimental and numerical studies of hydrodynamics and heat mass transfer in two-phase gas-liquid and gas-dispersed flows in pipes or ducts for engineering and natural systems that can be very useful for researchers and engineers in heat transfer and heat exchangers communities.