Non-invasive measurements of intralabyrinthine pressure changes by electrocochleography and otoacoustic emissions

Büki, Béla; Giraudet, Fabrice; Avan, Paul

doi:10.1016/j.heares.2009.02.004

Cited by 25 publications

(22 citation statements)

References 37 publications

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“…Evidence to support this second hypothesis is that OAEs are sensitive to positional changes, specifically in the low frequencies (de Kleine et al 2001; Voss et al 2006). However, previous reports documenting changes in OAE, ECoG, and oVEMP in response to postural changes have been limited to ACS stimuli (Buki et al 2009; de Kleine et al 2001; Jerin and Gürkov 2014; Voss et al 2006). In the present study, equal reduction in oVEMP amplitude regardless of stimulus type (ACS versus midline taps, Table 1), was found, suggesting that in addition to the cochlea, increased intralabyrinthine pressure may directly affect sensory structures in the vestibular system.…”

Section: Discussionmentioning

confidence: 99%

“…In patients with increased ICP secondary to hydrocephalus, intracranial tumors, etc, differences in tympanic membrane displacement during stapedial reflex testing were noted when compared to individuals with normal ICP (Reid et al 1990). OAEs, electrocochleography (ECoG), and recently oVEMP have also been measured in normal subjects after being placed on an inversion table (Buki et al 2000; Buki et al 2009; de Kleine et al 2000; de Kleine et al 2001; Deppe et al 2013; Jerin and Gürkov 2014; Voss et al 2006). ICP increases as a result of inversion, and because of the cochlear and vestibular aqueducts, intralabyrinthine pressure is increased in response to rises in ICP.…”

Section: Discussionmentioning

confidence: 99%

“…ICP increases as a result of inversion, and because of the cochlear and vestibular aqueducts, intralabyrinthine pressure is increased in response to rises in ICP. When intralabyrinthine pressure is increased, OAEs have been documented to show phase and magnitude changes (Buki et al 1996; Buki et al 2000; Buki et al 2009; de Kleine et al 2000; Deppe et al 2013; Voss et al 2006). Similarly, phase changes have also been documented in ECoG measurements (Buki et al 2009).…”

Section: Discussionmentioning

confidence: 99%

“…When intralabyrinthine pressure is increased, OAEs have been documented to show phase and magnitude changes (Buki et al 1996; Buki et al 2000; Buki et al 2009; de Kleine et al 2000; Deppe et al 2013; Voss et al 2006). Similarly, phase changes have also been documented in ECoG measurements (Buki et al 2009). However, these changes occur slowly, over 30–60 seconds, in most normal human subjects (Buki et al 2000; de Kleine et al 2001).…”

Section: Discussionmentioning

confidence: 99%

“…The mechanisms proposed to account for these response changes in the cochlea are that increased ICP may alter the biomechanics of the basilar membrane or the stiffness of the annular ligament, which in turn alters sound transmission, particularly for low frequency stimuli as a result of middle ear stiffness changes (Buki et al 2009; Olzowy et al 2008; Voss et al 2006). Evidence to support this second hypothesis is that OAEs are sensitive to positional changes, specifically in the low frequencies (de Kleine et al 2001; Voss et al 2006).…”

Section: Discussionmentioning

confidence: 99%

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The effect of increased intracranial pressure on vestibular evoked myogenic potentials in superior canal dehiscence syndrome

Janky

Zúñiga

Schubert

et al. 2015

Clinical Neurophysiology

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Objective To determine if vestibular evoked myogenic potential (VEMP) responses change during inversion in patients with superior canal dehiscence syndrome (SCDS) compared to controls. Methods Sixteen subjects with SCDS (mean: 43, range 30–57 years) and 15 age-matched, healthy subjects (mean: 41, range 22–57 years) completed cervical VEMP (cVEMP) in response to air conduction click stimuli and ocular VEMP (oVEMP) in response to air conduction 500 Hz tone burst stimuli and midline tap stimulation. All VEMP testing was completed in semi-recumbent and inverted conditions. Results SCDS ears demonstrated significantly larger oVEMP peak-to-peak amplitudes in comparison to normal ears in semi-recumbency. While corrected cVEMP peak-to-peak amplitudes were larger in SCDS ears; this did not reach significance in our sample. Overall, there was not a differential change in o- or cVEMP amplitude with inversion between SCDS and normal subjects. Conclusions Postural-induced changes in o- and cVEMP responses were measured in the steady state regardless of whether the labyrinth was intact or dehiscent. Significance VEMP responses are blunted during inversion. Although steady-state measurements of VEMPs during inversion do not increase diagnostic accuracy for SCDS, the findings suggest that inversion may provide more general insights into the equilibration of pressures between intracranial and intralabyrinthine fluids.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

The effect of increased intracranial pressure on vestibular evoked myogenic potentials in superior canal dehiscence syndrome

Janky

Zúñiga

Schubert

et al. 2015

Clinical Neurophysiology

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Electrophysiological Monitoring of Cochlear Function as a Non-invasive Method to Assess Intracranial Pressure Variations

Sakka¹,

Thalamy

Giraudet

et al. 2012

Acta Neurochirurgica Supplementum

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The "cochlear" aqueduct is a narrow channel connecting the subarachnoid and intralabyrinthine spaces. Through this communication, cerebrospinal fluid (CSF) pressure variations are transmitted to the intralabyrinthine space and modify the impedance of the ear. Distortion-product otoacoustic emissions (DPOAE) are sounds emitted by cochlear sensory cells in response to sonic stimulation. Cochlear microphonic potentials (CMP) express the electrophysiological activity of cochlear sensory cells. At 1 kHz, the phase of DPOAE and CMP varies according to the impedance of the ear and thus to intracranial pressure (ICP) variations. DPOAE and CMP have been shown to strictly follow ICP variations produced during infusion tests performed in the diagnosis of chronic hydrocephalus. DPOAE and CMP recordings appear to be valuable tools for monitoring ICP non-invasively.

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Posture-induced changes of ocular vestibular evoked myogenic potentials suggest a modulation by intracranial pressure

Jerin¹,

Gürkov²

2014

Exp Brain Res

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Ocular vestibular evoked myogenic potentials (oVEMPs) represent extraocular muscle activity in response to vestibular stimulation. We sought to investigate whether oVEMPs are modulated by increasing intracranial pressure (ICP). Air-conducted oVEMPs were elicited in 20 healthy subjects lying supine on a tilt table. In order to elevate the ICP, the table was stepwise tilted from the horizontal plane to a 30° declination, corresponding to a 0°, 10°, 20° and 30° head-down position. At each inclination angle, oVEMP recording was performed in two head positions: (1) the head in line with the body and (2) the head positioned horizontally with the body tilted. When tilting both the body and head, oVEMP amplitudes gradually declined from 4.59 μV at 0° to 2.24 μV at 30° head-down position, revealing a highly significant reduction in amplitudes for all tilt angles when compared to the baseline value (p < 0.001). In parallel, the response prevalence decreased and latencies prolonged. Similar effects were observed when the body was tilted but the head positioned horizontally, even though the decrease in oVEMP amplitudes was less pronounced. A gravitoinertial force effect upon the otolith organs could thereby be excluded as a possible confounder. Hence, oVEMPs were most likely modulated by increasing ICP. In the range of the horizontal plane to a 30° head-down tilt, there was a linear correlation between oVEMP amplitudes and the inclination angle. oVEMPs might in principle be suited for non-invasive ICP monitoring.

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Non-invasive measurements of intralabyrinthine pressure changes by electrocochleography and otoacoustic emissions

Cited by 25 publications

References 37 publications

The effect of increased intracranial pressure on vestibular evoked myogenic potentials in superior canal dehiscence syndrome

The effect of increased intracranial pressure on vestibular evoked myogenic potentials in superior canal dehiscence syndrome

Electrophysiological Monitoring of Cochlear Function as a Non-invasive Method to Assess Intracranial Pressure Variations

Posture-induced changes of ocular vestibular evoked myogenic potentials suggest a modulation by intracranial pressure

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