Non-invasive Transcranial Electrical Stimulation in Movement Disorders

Ganguly, Jacky; Murgai, Aditya; Sharma, Soumya; Aur, Dorian; Jog, Mandar

doi:10.3389/fnins.2020.00522

Cited by 35 publications

(23 citation statements)

References 126 publications

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“…Non-invasive techniques such as transcranial direct current stimulation (tDCS) have demonstrated that external stimulation of parietal areas including the angular gyrus can induce extensive changes in resting-state activity of sensorimotor and cognitive areas ( Clemens et al, 2014 ). However, for PD patients, applications of tDCS have been limited to stimulation of motor and frontal areas with modest benefit ( Costa-Ribeiro et al, 2016 ; Dobbs et al, 2018 ; Ganguly et al, 2020 ). Knowledge of the specific PD circuitry illustrated in this study may guide future external modulation of key regions using newer therapeutic methodologies.…”

Section: Discussionmentioning

confidence: 99%

Spectral guided sparse inverse covariance estimation of metabolic networks in Parkinson's disease

Spetsieris

Eidelberg

2021

NeuroImage

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In neurodegenerative disorders, a clearer understanding of the underlying aberrant networks facilitates the search for effective therapeutic targets and potential cures. [ 18 F]-fluorodeoxyglucose (FDG) positron emission tomography (PET) imaging data of brain metabolism reflects the distribution of glucose consumption known to be directly related to neural activity. In FDG PET resting-state metabolic data, characteristic disease-related patterns have been identified in group analysis of various neurodegenerative conditions using principal component analysis of multivariate spatial covariance. Notably, among several parkinsonian syndromes, the identified Parkinson’s disease-related pattern (PDRP) has been repeatedly validated as an imaging biomarker of PD in independent groups worldwide. Although the primary nodal associations of this network are known, its connectivity is not fully understood. Here, we describe a novel approach to elucidate functional principal component (PC) network connections by performing graph theoretical sparse network derivation directly within the disease relevant PC partition layer of the whole brain data rather than by searching for associations retrospectively in whole brain sparse representations. Using sparse inverse covariance estimation of each overlapping PC partition layer separately, a single coherent network is detected for each layer in contrast to more spatially modular segmentation in whole brain data analysis. Using this approach, the major nodal hubs of the PD disease network are identified and their characteristic functional pathways are clearly distinguished within the basal ganglia, midbrain and parietal areas. Network associations are further clarified using Laplacian spectral analysis of the adjacency matrices. In addition, the innate discriminative capacity of the eigenvector centrality of the graph derived networks in differentiating PD versus healthy external data provides evidence of their validity.

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Section: Discussionmentioning

confidence: 99%

Spectral guided sparse inverse covariance estimation of metabolic networks in Parkinson's disease

Spetsieris

Eidelberg

2021

NeuroImage

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“…The concept that PD symptoms are related to dysfunction in the multilevel, interconnected complex cortex-basal ganglia network, rather than the basal ganglia only, has opened up the possibility of modifying these networks by NIBS [34]. However, the application of tACS to PD symptoms has remained experimental, and a systematic review concluded there was no evidence supporting the treatment of PD using tACS [33].…”

Section: Pdmentioning

confidence: 99%

“…There is accumulating evidence that abnormal oscillatory brain activity and changes in oscillatory communication within and between motor-related regions are associated with motor deficits in patients with stroke and Parkinson's disease (PD) [29][30][31][32]. Therefore, tACS has emerged as a promising therapeutic approach for ameliorating motor deficits by non-invasively modulating oscillatory brain activity and communication via entrainment of specific frequency oscillations [33,34]. Despite its clinical potential, tACS studies aimed at ameliorating motor deficits in patients with stroke and PD remain scarce.…”

Section: Introductionmentioning

confidence: 99%

Motor Learning Based on Oscillatory Brain Activity Using Transcranial Alternating Current Stimulation: A Review

Takeuchi

Izumi

2021

Brain Sciences

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Developing effective tools and strategies to promote motor learning is a high-priority scientific and clinical goal. In particular, motor-related areas have been investigated as potential targets to facilitate motor learning by noninvasive brain stimulation (NIBS). In addition to shedding light on the relationship between motor function and oscillatory brain activity, transcranial alternating current stimulation (tACS), which can noninvasively entrain oscillatory brain activity and modulate oscillatory brain communication, has attracted attention as a possible technique to promote motor learning. This review focuses on the use of tACS to enhance motor learning through the manipulation of oscillatory brain activity and its potential clinical applications. We discuss a potential tACS–based approach to ameliorate motor deficits by correcting abnormal oscillatory brain activity and promoting appropriate oscillatory communication in patients after stroke or with Parkinson’s disease. Interpersonal tACS approaches to manipulate intra- and inter-brain communication may result in pro-social effects and could promote the teaching–learning process during rehabilitation sessions with a therapist. The approach of re-establishing oscillatory brain communication through tACS could be effective for motor recovery and might eventually drive the design of new neurorehabilitation approaches based on motor learning.

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“…There is a large and growing body of work demonstrating benefits of tES for neurorehabilitation (Brunoni et al, 2014;Cioato et al, 2016;Sasso et al, 2016;Aftanas et al, 2018;Leffa et al, 2018). In addition, tES applied as an add-on technique with cognitive or physical rehabilitation improve training outcomes, as widely demonstrated in a range of neurological conditions including post-stroke recovery (Babyar et al, 2016;Sebastian et al, 2016;Bornheim et al, 2020;Yan et al, 2020), multiple sclerosis (MS; Charvet et al, 2018;Pilloni et al, 2020), and Parkinson's disease (Agarwal et al, 2018;Ganguly et al, 2020).…”

Section: Role In Post-acute Recovery Of Functionmentioning

confidence: 99%

Update on the Use of Transcranial Electrical Brain Stimulation to Manage Acute and Chronic COVID-19 Symptoms

Pilloni

Bikson

Badran

et al. 2020

Front. Hum. Neurosci.

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The coronavirus disease 19 (COVID-19) pandemic has resulted in the urgent need to develop and deploy treatment approaches that can minimize mortality and morbidity. As infection, resulting illness, and the often prolonged recovery period continue to be characterized, therapeutic roles for transcranial electrical stimulation (tES) have emerged as promising non-pharmacological interventions. tES techniques have established therapeutic potential for managing a range of conditions relevant to COVID-19 illness and recovery, and may further be relevant for the general management of increased mental health problems during this time. Furthermore, these tES techniques can be inexpensive, portable, and allow for trained self-administration. Here, we summarize the rationale for using tES techniques, specifically transcranial Direct Current Stimulation (tDCS), across the COVID-19 clinical course, and index ongoing efforts to evaluate the inclusion of tES optimal clinical care.

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Non-invasive Transcranial Electrical Stimulation in Movement Disorders

Cited by 35 publications

References 126 publications

Spectral guided sparse inverse covariance estimation of metabolic networks in Parkinson's disease

Spectral guided sparse inverse covariance estimation of metabolic networks in Parkinson's disease

Motor Learning Based on Oscillatory Brain Activity Using Transcranial Alternating Current Stimulation: A Review

Update on the Use of Transcranial Electrical Brain Stimulation to Manage Acute and Chronic COVID-19 Symptoms

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