Non-ionic iodinated contrast media related immediate reactions: A mechanism study of 27 patients

Zhai, Liqin; Guo, Xiangjie; Zhang, Haoyue; Jin, Qianqian; Zeng, Qiang; Tang, Xiaoxian; Gao, Cai-rong

doi:10.1016/j.legalmed.2016.11.006

Cited by 7 publications

(4 citation statements)

References 26 publications

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“…We also measured circulating levels of PGD2 in obese subjects before and after gastric bypass surgery ( Fig 4J–K ). Circulating levels of PGD2 in obese patients were approximately 2 fold higher than the clinical reference rage for normal individuals ( 57 , 61 – 64 ). Furthermore, after substantial weight loss of ~35% (average BMI reduced from 43.6 to 28.2) PGD2 levels were unchanged one year after gastric bypass surgery.…”

Section: Resultsmentioning

confidence: 76%

Obesity-induced changes in lipid mediators persist after weight loss

et al. 2017

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BackgroundObesity induces significant changes in lipid mediators, however, the extent to which these changes persist after weight loss has not been investigated.Subjects/MethodsWe fed C57BL6 mice a high fat diet to generate obesity and then switched the diet to a lower fat diet to induce weight loss. We performed a comprehensive metabolic profiling of lipid mediators including oxylipins, endocannabinoids, sphingosines and ceramides in key metabolic tissues including adipose, liver, muscle, hypothalamus and plasma.ResultsWe found that changes induced by obesity were largely reversible in most metabolic tissues but the adipose tissue retained a persistent obese metabolic signature. Prostaglandin signaling was perturbed in the obese state and lasting increases in PGD2, downstream metabolites 15-deoxy PGJ2 and delta-12-PGJ2 were observed after weight loss. Furthermore, the enzyme responsible for PGD2 synthesis (hematopoietic prostaglandin D synthase, HPGDS) was increased in obese adipose tissues and remained high after weight loss. We found that inhibition of HPGDS over the course of 5 days resulted in decreased food intake in mice. Increased HPGDS expression was also observed in human adipose tissues compared with lean individuals. We then measured circulating levels of PGD2 in obese patients before and after weight loss and found that while elevated relative to lean subjects, levels of this metabolite did not decrease after significant weight loss.ConclusionsThese results suggest that lasting changes in lipid mediators induced by obesity, still present after weight loss, may play a role in the biological drive to regain weight.

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Section: Resultsmentioning

confidence: 76%

Obesity-induced changes in lipid mediators persist after weight loss

et al. 2017

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“…Safety is a major concern in the use of iodine contrast agents, and all clinical strategies are used to avoid or reduce the ADR to iodine contrast agents which was initially thought to be an allergy-like reactions rather than a true immunoglobulin E (IgE) mediated hypersensitivity. These reactions are thought to result from the activation of complement, brinolytic system, and kinin system, as well as the release of histamine, prostaglandin, bradykinin, and other mediators [4].However, studies have shown that because of the release of histamine and trypsin and the occurrence of positive skin tests, the IgE mediated allergic mechanism is also one of the evidences for the occurrence of acute adverse reactions of iodine contrast agents [5] [6].Studies have shown that patients with IgE-mediated allergy-like reactions have a history of exposure to relevant allergens [7]. The data of this retrospective analysis showed that only 11 patients who had been exposed to iodine contrast agents should not be excluded from the IgE mediated acute adverse reactions of iodine contrast agents.…”

Section: Discussionmentioning

confidence: 99%

“…3) Iopromide (I 3 , Ultrvist 370, Bayer Pharmaceutical Co. Ltd) for CTA/CTU scan of patients over 85 kg. 4) Iodixanol (I 4 , Jiangsu Hengrui Pharmaceutical Co. Ltd), 270 mgI/ml for enhanced visceral scan and CTA/CTU scan of patients below 85 kg, 5) Iopromide, Iodixanol and Iohexol were randomly used for angiographic administration: whole cerebral arteriography, 5-10ml at a time; selective coronary artery, 4-8ml at a time; peripheral artery, 30-60ml at a time; aortic angiography, 40-60ml at a time De nition of acute adverse reactions According to the ESUR Contrast Media Safety Guidelines Version 10.0 [4], acute adverse reaction de nes to an adverse reaction which occurs within 1 hour of contrast agent injection. Acute reactions are either allergy-like, hypersensitivity reactions or chemotoxic responses.…”

Section: Types Of Examinationmentioning

confidence: 99%

“…In this study, the incidence of ADR of iodine contrast agent in arteriography was signi cantly lower than that of intravenous administration, which also indicated from another perspective that high viscosity contrast agents may produce more adverse reactions during intravenous administration. 4. Whether fasting, hydration, heating and corticosteroid prophylaxis can reduce the incidence of adverse reactions?…”

Section: Risk Factors Related To Adverse Reactions Of Iodine Contrast Agentsmentioning

confidence: 99%

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Retrospective Analysis of Acute Adverse Reactions of 4 Iodine Contrast Agents

Zhu

Zheng

Wang

et al. 2021

Preprint

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Objective Incidence of acute adverse reactions (ADR) of 4 kinds of iodine contrast agents were retrospective analyzed in 10532 cases of CT enhanced scan and 6130 cases of arteriography in our hospital, and to investigate the safety of these 4 types agents in clinical application.Materials and Methods The occurrence of ADR to Iohexol, Ioversol, Iopromide and Iodixanol (expressed as I1, I2, I3 and I4) were recorded in detail from August,2007. 36 months' data were analyzed by Fisher's `Exact Test. The incidences of ADR were calculated, and medicine information and features of adverse reactions induced by these 4 types agents are analyzed. Results: CT enhanced scan and arteriography was performed in 16662 cases, including body enhanced scan, CTA ，CTU and arteriography. Acute adverse reactions occurred in 25 cases, and the incidence of ADR was 0.15%. Among them, 18 cases had mild ADR (0.10%), 7 cases had moderate ADR (0.04%) and 0 cases had severe acute adverse reaction. There was a difference in the incidence of acute adverse reaction between the 4 contrast agents used (X2=5.854, p=0.022). I4 had the highest incidence of ADR, it was 0.32%, and the lowest incidence of ADR occurred in I2, it`s 0.08%. The incidence of ADR with I1 and I3 was 0.14% and 0.18%, respectively. The incidence of ADR in intravenous administration was significantly higher than that in arterial administration（X2=4.655，p=0.036）. Conclusion In this study, the incidence of acute adverse reaction to Iodixanol was the highest, and Ioversol was the lowest. The incidence of ADR in arteriography was significantly lower than that in patients with intravenous administration enhanced CT.

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