Aim: This research paper aims to modeling and finite element analysis of PEEK 450G biomaterial used as cardiovascular stent implant. Methods: Commercially available CATIA V5 and ABAQUS 6.0 software were used for modeling and finite element analysis of cardiovascular stent implant to evaluate the radial displacement, stress distribution, and plastic strain in the proximal area of PEEK 450G biomaterial under pressure load conditions of 0.8, 1.0, and 1.2 MPa. Results: The results show that, both in non-linear bending analysis and non-linear pressure analysis, that PEEK 450G stent exhibits very good radial expansion and lowest stress concentration in plaque and also which is well below the yield level (100 MPa), however plastic strain is quite high. Conclusion: The blood circulation will be appropriate and also chances of vessel damage may be reduced more. Hence the study reveals that PEEK 450G can be best alternate biomaterial appropriate for cardiovascular stent implant.