Cardiovascular disease such as atherosclerosis is one of the most common diseases in modern days which may cause pain and heart attack. Stenting is non surgical method to treat the atherosclerosis. Due to its efficiency and simplicity, the use of coronary stents in interventional procedures has rapidly increased and different stents have been introduced in the market. In order to have better output of the stent implantation, it is needed to analyze the mechanical behavior of this device before manufacturing and utilizing. The aim of this work is to investigate the biomechanical behavior of stent such as non linear bending analysis at different loading conditions by using different biomaterials. One of the most effective methods to investigate the biomechanical behavior of the stent is finite element method. A commercially available finite element package ABAQUS6.10 has been used for the analysis.

Zirconia is a bioinert ceramic biomaterial. Zirconia having composition of 97% Zirconia oxide and 3% Yttria oxide finds its vital application in the field of dental ceramics as an implant material for having good inert characteristics like minimum interaction with the adjacent tissues and exhibits good aesthetic property. This paper presents the in-vitro tests conducted to evaluation toxicity by cell culturing on zirconia biomaterial used in the dental implant by both direct contact and extraction method. In the present study, in-vitro assessment of tissue biocompatibility was conducted on L929 cell line (mouse fibroblast). Invitro test, the toxicity of Zirconia specimen was done by computing percentage of viability in a cell-cultured medium. An MTT system was used to measure the active cell activities with mitochondrial dehydrogenases, which is an easy method which gives accurate and precision results. The results of biocompatibility in-vitro test by both Direct and Extraction methods confirmed that Zirconia exhibits the highest cell growth of 93.17% and resulted with zero-grade cytotoxicity. Zirconia having good aesthetic characteristics, i.e. colour of the implant matches with the tooth colour. Hence Zirconia is a candidate implant material than other metal implants.

Aim: This research paper aims to modeling and finite element analysis of PEEK 450G biomaterial used as cardiovascular stent implant. Methods: Commercially available CATIA V5 and ABAQUS 6.0 software were used for modeling and finite element analysis of cardiovascular stent implant to evaluate the radial displacement, stress distribution, and plastic strain in the proximal area of PEEK 450G biomaterial under pressure load conditions of 0.8, 1.0, and 1.2 MPa. Results: The results show that, both in non-linear bending analysis and non-linear pressure analysis, that PEEK 450G stent exhibits very good radial expansion and lowest stress concentration in plaque and also which is well below the yield level (100 MPa), however plastic strain is quite high. Conclusion: The blood circulation will be appropriate and also chances of vessel damage may be reduced more. Hence the study reveals that PEEK 450G can be best alternate biomaterial appropriate for cardiovascular stent implant.

Abstract-Coronary stent implantation is one of the most important procedures to treating coronary artery disease such atherosclerosis. Due to its efficiency, flexibility and simplicity, the use of coronary stents procedures has increased rapidly. In order to have better output of stent implantation, it is needed to analyze the biomechanical behavior of this device before manufacturing and utilizing. Finite element method is one of the most effective methods to investigate biomechanical behavior of the stent. The objective of this research work is to investigate expansion characteristics of coronary stent for diverse materials, such as PEEK 450G, Magnesium AZ31 and CobaltChromium L605. The results demonstrate the radial displacement, dogbone ratio, foreshortening, and flexibility of diverse materials.

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