Non-mammalian Toll-like receptor 18 (Tlr18) recognizes bacterial pathogens in common carp (Cyprinus carpio L.): Indications for a role of participation in the NF-κB signaling pathway

Shan, Shijuan; Liu, Dezhi; Liu, Rongrong; Zhu, Yuying; Li, Ting; Zhang, Fumiao; An, Liguo; Gao, Yang; Li, Hua

doi:10.1016/j.fsi.2017.09.081

Cited by 68 publications

(38 citation statements)

References 51 publications

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“…At the initiation of the inflammatory response, stimulation of dendritic cells and macrophages by foreign antigens leads to secretion of a series of pro‐inflammatory cytokines . At the same time, the pathogen itself may also produce metabolites that accumulate and spread to the surrounding tissues, forming a concentration gradient centered around the site of infection .…”

Section: Inflammation and Inflammatory Disordersmentioning

confidence: 99%

“…The role of HDAC6 in the adaptive CD4 + T‐cell response has been studied in several autoimmune and inflammatory situations, such as colitis and cardiac allograft rejection . In the process of an innate immune response to fight against intracellular bacterial infections, HDAC6 participates in the indication of the pro‐inflammatory transcriptional program through the Toll‐like receptor pathway, which is triggered by sensing of cell‐surface and endo‐phagosomal bacteria …”

Section: Structure and Function Of Hdac6mentioning

confidence: 99%

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Targeted inhibition of histone deacetylase 6 in inflammatory diseases

Ran

Zhou

2019

Thoracic Cancer

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Targeting epigenetic modification of gene expression represents a promising new approach under investigation for the treatment of inflammatory diseases. Accumulating evidence suggests that epigenetic mechanisms, such as histone modification, play a crucial role in a number of inflammatory diseases, including rheumatoid arthritis, asthma, and contact hypersensitivity. Consistent with this role, histone deacetylase (HDAC) inhibitors have shown efficacy in the treatment of inflammatory diseases. In particular, selective inhibitors of HDAC6, a cytoplasmic member of the HDAC family that contains two deacetylase domains, are under investigation as a potential treatment strategy for inflammatory diseases due to their ability to regulate inflammatory cells and cytokines. Here, we review recent findings highlighting the critical roles of HDAC6 in a variety of inflammatory diseases, and discuss the therapeutic potential of HDAC6 inhibitors in these settings.

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Section: Inflammation and Inflammatory Disordersmentioning

confidence: 99%

Section: Structure and Function Of Hdac6mentioning

confidence: 99%

Targeted inhibition of histone deacetylase 6 in inflammatory diseases

Ran

Zhou

2019

Thoracic Cancer

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“…All living things experience adverse conditions at some point during their lifespan . Plants and animals are subjected to abiotic and biotic stresses that include salt, drought, and pathogens . Environmental stresses also affect organisms at the cellular level.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic targeting of cellular stress responses in cancer

Chen

Xie

2018

Thoracic Cancer

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Similar to bacteria, yeast, and other organisms that have evolved pathways to respond to environmental stresses, cancer cells develop mechanisms that increase genetic diversity to facilitate adaptation to a variety of stressful conditions, including hypoxia, nutrient deprivation, exposure to DNA‐damaging agents, and immune responses. To survive, cancer cells trigger mechanisms that drive genomic instability and mutation, alter gene expression programs, and reprogram the metabolic pathways to evade growth inhibition signaling and immune surveillance. A deeper understanding of the molecular mechanisms that underlie the pathways used by cancer cells to overcome stresses will allow us to develop more efficacious strategies for cancer therapy. Herein, we overview several key stresses imposed on cancer cells, including oxidative, metabolic, mechanical, and genotoxic, and discuss the mechanisms that drive cancer cell responses. The therapeutic implications of these responses are also considered, as these factors pave the way for the targeting of stress adaption pathways in order to slow cancer progression and block resistance to therapy.

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“…() and Shan et al . (). Briefly, before the A. hydrophila challenge experiment in C. carpio , the bacteria were activated and cultured on Luria‐Bertani (LB) medium in a shaker incubator at 28°C overnight.…”

Section: Methodsmentioning

confidence: 97%

“…A total of 50 healthy C. carpio were intraperitoneally injected with 500 μl phosphate-buffered saline (PBS 7.4) containing poly I:C (1.6 mg ml −1 , Sigma; www.sigmaaldrich.com). Immunostimulation of Aeromonas hydrophila was performed according to the protocols of Li et al (2013), Yang et al (2014), Li et al (2018c) and Shan et al (2018a).…”

Section: Immune Challenge In Vivo and Sample Collectionmentioning

confidence: 99%

Molecular characterization and functional analysis of interferon regulatory factor 9 (irf9) in common carp Cyprinus carpio: a pivotal molecule in the Ifn response against pathogens

Zhu

Shan

et al. 2019

Journal of Fish Biology

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In the present study, interferon (IFN) regulatory factor (IRF) 9 gene (irf9) was identified and characterized in common carp Cyprinus carpio. The predicted protein sequence of Irf9 contains a DNA binding domain (DBD) that possess five tryptophans, an IRF association domain (IAD) and two nuclear localisation signals (NLS). Alignment of Irf9 of C. carpio with the corresponding Irf9 proteins of other species showed that the DBD is more highly conserved than the IAD. The putative Irf9 protein sequence of C. carpio shares higher identities with teleosts (53.8–82.3%) and lower identities with mammals (30.2–31.0%). Phylogenetic studies of the putative amino‐acid sequence of IRF9 based on the neighbour‐joining method showed that Irf9 of C. carpio has the closest relationship with the grass carp Ctenopharyngodon idella. Tissue distribution analysis showed that irf9 transcripts were detectable in all examined tissues with the highest expression in the skin and the lowest expression in the head kidney. Poly I:C and Aeromonas hydrophila stimulation up‐regulated irf9 expression in the spleen, head kidney, foregut and hindgut at different time intervals. In addition, irf9 was induced by Poly I:C and lipopolysaccharides (LPS) in vitro. These results indicate that Irf9 participates in antiviral and antibacterial immunity. Transfection of irf9 up‐regulated the expression of cytokines, including type I IFN, protein kinase R (PKR), interferon‐stimulated gene (ISG)15 and tumour necrosis factor (TNF)α in epithelioma papulosum cyprini cells (EPC) upon poly I:C and LPS stimulation. A dual‐luciferase reporter assay revealed that Irf9 has no effect on NF‐κB activation. The present study on Irf9 provides new insights into the IFN system of C. carpio and a valuable experimental platform for future studies on the immune system of fish.

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Non-mammalian Toll-like receptor 18 (Tlr18) recognizes bacterial pathogens in common carp (Cyprinus carpio L.): Indications for a role of participation in the NF-κB signaling pathway

Cited by 68 publications

References 51 publications

Targeted inhibition of histone deacetylase 6 in inflammatory diseases

Targeted inhibition of histone deacetylase 6 in inflammatory diseases

Therapeutic targeting of cellular stress responses in cancer

Molecular characterization and functional analysis of interferon regulatory factor 9 (irf9) in common carp Cyprinus carpio: a pivotal molecule in the Ifn response against pathogens

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