Isothermal transformations are minimally dissipative but slow processes, as the system needs to remain close to thermal equilibrium along the protocol. Here, we show that smoothly modifying the system-bath interaction can significantly speed up such transformations. In particular, we construct protocols where the overall dissipation W diss decays with the total time τ tot of the protocol as W diss ∝ τ −2α−1 tot , where each value α > 0 can be obtained by a suitable modification of the interaction, whereas α ¼ 0 corresponds to a standard isothermal process where the system-bath interaction remains constant. Considering heat engines based on such speed-ups, we show that the corresponding efficiency at maximum power interpolates between the Curzon-Ahlborn efficiency for α ¼ 0 and the Carnot efficiency for α → ∞. Analogous enhancements are obtained for the coefficient of performance of refrigerators. We confirm our analytical results with two numerical examples where α ¼ 1=2, namely the time-dependent Caldeira-Leggett and resonant-level models, with strong system-environment correlations taken fully into account. We highlight the possibility of implementing our proposed speed-ups with ultracold atomic impurities and mesoscopic electronic devices.