AimThis study sought to determine the factors influencing successful implementation of non‐medical prescribing (NMP).Data sourcesEMBASE, Medline, CINAHL and reference lists were searched from January 2010 to November 2020.Study SelectionUmbrella review and narrative synthesis of results were utilised. The retrieved reviews underwent title screening, abstract review, full‐text screening and assessment for inclusion. To guarantee the precision of the search results, Participants, Intervention, Control, and Outcomes (PICO) elements were recorded for each study. Studies were included if they were systematic reviews, published in English, published from January 2010 to November 2020, and discussed barriers and/or facilitators to NMP implementation.ResultsOf the 193 studies identified, eight were eligible for inclusion. Most of the reviews (62%) were published in 2017–2018. The majority of the reviews (62%) were focused on the United Kingdom. Three reviews discussed nurse prescribing, two reviews focused on pharmacist prescribing, and three reviews investigated NMP generally. Data were compiled into the Consolidated Framework for Implementation Research to evaluate the factors that influence the success or failure of NMP implementation.ConclusionImplementation of NMP is a complex process which requires fulfilment of all its elements. The success of NMP can be directly related to the extent of the whole system engagement and support, and available funding.