Non‐Melanoma Skin Cancer and Other Epidermal Skin Tumours

Quinn, Anthony G.; Perkins, William

doi:10.1002/9781444317633.ch52

Cited by 47 publications

(84 citation statements)

References 439 publications

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“…Pathogenesis of psoriasis and BCC is associated with keratinocytes hyperproliferation and their differentiation disorders, activation, adhesion, and migration of keratinocytes and endothelial cells, chronic inflammation, and angiogenesis [23,26,43,55,58]. The plasminogen system is known to be involved in all of these processes.…”

Section: Discussionmentioning

confidence: 99%

Increased expression of uPA, uPAR, and PAI-1 in psoriatic skin and in basal cell carcinomas

et al. 2017

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There is substantial evidence implicating the urokinase system in tissue remodeling during neo-vascularization, inflammation, tumor invasion, and metastasis. Regulated degradation of the extracellular matrix at the leading edge of migrating cells, mediated by uPA and uPAR, is required for tissue remodeling, invasiveness, and angiogenesis. Psoriasis and basal cell carcinoma (BCC) are the most common skin diseases. Pathogenesis of both of them is associated with keratinocyte hyperproliferation, inflammatory cell migration, and angiogenesis-processes in which the plasminogen system (uPA, uPAR, tPA, and PAI-1) plays a crucial role. In the present study, the comparative analysis of uPA, uPAR, tPA, and PAI-1 expression in the normal skin, in the biopsies of patients with psoriasis vulgaris, and BCC was carried out. uPA, uPAR, and PAI-1 expression was up-regulated in the epidermis of psoriatic skin and in tumor cells in BCC. Increased uPAR expression was detected in the derma of psoriatic lesions and in the stroma surrounding tumor cells in BCC. Increased expression of uPA in epidermal cells in psoriasis and in tumor cells in BCC suggests an important role of the uPA system for aggressively proliferating and invading cells of epidermal origin. A possible activation of the stroma, as a result of uPA-uPAR interaction between tumor cells and the surrounding stroma, is suggested.

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Section: Discussionmentioning

confidence: 99%

Increased expression of uPA, uPAR, and PAI-1 in psoriatic skin and in basal cell carcinomas

et al. 2017

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“…Przegląd Dermatologiczny 2017/1 introduction Skin tags (ST) are common, benign skin lesions composed of loose fibrous tissue and occurring mainly on the neck and major flexures as small, soft, pedunculated protrusions [1]. Apart from their cosmetic impact, they have now been linked to various metabolic complications [2,3] such as diabetes mellitus (DM), dyslipidemia, obesity and cardiovascular diseases, and may therefore serve as a marker of underlying systemic disorders.…”

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confidence: 99%

A clinicoepidemiological study of skin tags and their association with metabolic syndrome

Srivastava¹,

Khare²,

Gupta³

et al. 2017

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Introduction. Skin tags are known to be associated with several systemic diseases such as diabetes mellitus, obesity, dyslipidemia and cardiovascular diseases. Only a few Indian studies have investigated patients with skin tags for underlying metabolic complications. Objective. To assess the clinico-epidemiological profile of patients with skin tags and evaluate them for underlying metabolic abnormalities. Material and methods. All the patients reporting skin tag(s) at the dermatology outpatient department from October 2013 to September 2014 were included in the study. A detailed general, cutaneous and systemic examination was carried out. The data were analyzed using the c 2 test. A p-value < 0.05 was considered significant. Results. Out of 165 enrolled patients, 112 (67.88%) completed the study protocol. Females outnumbered males, the M : F ratio being 1 : 1.11. Most patients (32; 28.57%) were in the age group of 31-40 years. The majority of the patients (77; 68.75%) reported after 1 year of noticing the lesions. The most commonly affected site was the neck (99; 88.39%) followed by the axilla (53; 47.32%). Acanthosis nigricans was the most common skin disease associated with skin tags (37; 33.03%). The diagnostic criteria for metabolic syndrome were fulfilled by 47 (41.96%) patients. The majority of the patients (70; 62.5%) were either overweight or obese. Abnormal glucose tolerance and hypertension were found in 41 (36.6%) and 37 (33.03%) of the patients respectively. Above optimal LDL cholesterol was the most common lipid abnormality, detected in 64 (56.25%) of the cases. Patients with 11 or more skin tags lesions and those with involvement of the thigh, axilla or neck were more likely to have metabolic syndrome. Conclusions. Patients with skin tags should be screened for concomitant diseases such as diabetes, hypertension, dyslipidemia and cardiovascular disease. Early detection of these complications followed by appropriate lifestyle changes and/or drug therapy would be beneficial in terms of reducing the considerable morbidity and mortality.

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“…In some cases, the proliferating cells may be surrounded by relatively normal epidermal cells to give a characteristic “Borst-Jadassohn” appearance. [10]…”

Section: Discussionmentioning

confidence: 99%

Anti-retroviral therapy's miracle in the treatment of Bowen's disease in a human immunodeficiency virus-positive patient: A rare case report

Gopalan

Vellaisamy

Manickam

et al. 2016

Indian J Sex Transm Dis

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Bowen's disease (BD) is a form of squamous cell carcinoma in situ often associated with human papillomavirus. Co-infection with human immunodeficiency virus (HIV) is associated with a greater risk of malignancy. We describe a case of BD in a 52-year-old unmarried HIV-positive male who presented with extensive skin lesions of 1-year duration. Histopathology was suggestive of BD. He had been tried with topical imiquimod cream and cryo-therapy for 6 months. We observed no response for these above therapies. He was started on with anti-retroviral therapy (ART) as his CD4 count was 253 cells/mm3. The entire cutaneous lesions completely disappeared within 6 months of ART, which was an interesting incidence.

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Non‐Melanoma Skin Cancer and Other Epidermal Skin Tumours

Cited by 47 publications

References 439 publications

Increased expression of uPA, uPAR, and PAI-1 in psoriatic skin and in basal cell carcinomas

Increased expression of uPA, uPAR, and PAI-1 in psoriatic skin and in basal cell carcinomas

A clinicoepidemiological study of skin tags and their association with metabolic syndrome

Anti-retroviral therapy's miracle in the treatment of Bowen's disease in a human immunodeficiency virus-positive patient: A rare case report

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