Non-molting dwarf (nm-d) as a mutant of Bombyx mori with a defect in purine synthesis

Uric acid metabolism modulates diet-dependent responses to intraspecific competition in Drosophila larvae

“…In conclusion, I showed that the uric acid metabolic pathway is an important hub for the integration of various environmental signals that affect larval responses to diet and intraspecific competition levels. The purine metabolism—to which the uric acid metabolism belongs—is a cornerstone biochemical pathway for larval metamorphosis and growth 77 , 78 as well as the relationship between insects and its symbionts. 79 Thus, demonstrating the functional role of the uric acid metabolism on larval responses to conditions in the developmental environments provides an important step change toward an integrated eco-physiological understanding of insect development.…”

Functional characterization of Bmcap in uric acid metabolism in the silkworm

“…, 2018; Fujii & Banno, 2019; Fujii et al. , 2021), result in phenotypes similar to that of the Bm5’N mutants (Fujii et al. , 2010; Wang et al.…”

“…Bm5'N mutants have a general highly transparent phenotype in the G0 and G1 stages of larval development. Mutations in other genes involved in the synthesis of uric acid, BmXDH1, BmMocoS, and BmATIC (Fujii et al, 2018;Fujii & Banno, 2019;Fujii et al, 2021), result in phenotypes similar to that of the Bm5'N mutants (Fujii et al, 2010;Wang et al, 2013a;Zhang et al, 2017). Previous investigations, entailing the admin-istration of 14 C-labeled uric acid into B. mori and M. sexta larvae, have authenticated the conveyance of uric acid through the hemolymph and its accumulation within the epidermis (Tamura, 1983;Buckner & Newman, 1990).…”