The equivalence principle, being one of the building blocks of general relativity, seems to be crucial for analysis of quantum effects in gravity. In this paper we consider the relation between the equivalence principle and the consistency of quantum information processing in gravitational field. We propose an analysis with a looped evolution consisting of steps both in the gravitational field and in the accelerated reference frame. We show that without the equivalence principle the looped quantum evolution cannot be unitary and looses its consistency. For this reasoning the equivalence principle is formulated in terms of the gauge transformations and is analyzed for particles acquiring an appropriate phase associated with the action over the looped path. In consequence, to keep consistency of quantum operations in gravitational field, it is required to keep a quantum variant of the equivalence principle. This proves importance of the quantized version of this fundamental gravitational principle for quantum information processing.