Non-osteogenic fibroma of the mandibular condyle

The Non-ossifying Fibroma: A Case Report and Review of the Literature

“…The radiographic appearance as a well-demarcated multilocular radiolucency with sclerotic borders in the current case and in the majority of other cases reported in the mandible [16,18,19,21] is similar to the typical radiographic appearance in the long bones [7,20].…”

“…In contrast, NOF of the long bones appears more commonly in males [7,20]. Our review of the reported cases of NOF in the mandible demonstrated that 71 % of them occurred in females (male to female ratio of 1:2.3) [ Table 1].…”

“…While the definitive etiology of the NOF is unclear, it is considered to be a disturbance of growth or dystrophic calcification, rather than a tumor or neoplasm [10,20]. The presence of the NOF outside tooth-bearing areas, however, excludes an odontogenic origin [5].…”

“…Histologically, the NOF consists of spindle-celled fibrous tissue in a storiform pattern with a variable number of multinucleated giant cells, hemosiderin pigment within fibroblasts, and lipid-laden histiocytes (xanthoma cells) [3,4]. This histologic make-up is reflected in the gross appearance of the lesion: the cut surface of the gross specimen typically appears yellow, due to the lipid content, with a varied degree of brown speckling depending upon the amount of hemosiderin deposition [7,20]. In addition, occasional lymphocytes and endothelial-lined blood vessels are present [17,19,20].…”

“…This histologic make-up is reflected in the gross appearance of the lesion: the cut surface of the gross specimen typically appears yellow, due to the lipid content, with a varied degree of brown speckling depending upon the amount of hemosiderin deposition [7,20]. In addition, occasional lymphocytes and endothelial-lined blood vessels are present [17,19,20]. The background stroma is composed of reticulin fibers [13,23].…”