Non-Pressurized Topical Spray Pharmaceutical-Methodology of Formulation Development and Quality Control Management

Abstract

The medicine was given to the target site with a pressurized topical spray (aerosol pharmaceutical) and a non-pressurized topical spray solution by gently pressing the spray container against the skin and initiating the spray. Formulation components consists of product concentrate (one or more pharmaceutical drugs with relevant excipient) and packaging components (valves, pump, actuator, container). After formulation process development various quality control test like spray pattern, spray content uniformity and geometry, particulate matter, droplet size distribution, microbial limit, net content, pH, osmolarity, weight loss, leachability, viscosity, valves, actuators, diptubes, weight checking, leak test, valve discharge rate, dosage with valves, therapeutic activity, and toxicity studies to check the quality and efficacy. The benefit of Topical Spray Life Cycle Management (post-approval adjustments, 30-day supplements, annual report, Food and Drug Administration inspection and enforcement, cover letter, risk management standard and related information from the International Organization for Standardization) is that it covers the entire lifecycle of a topical spray, from conception through formulation design development to marketing. The product lifecycle management data offers regulatory bodies with a significant financial benefit. Topical non-pressurized sprays have been developed for a variety of applications due to their ease of use, environmental friendliness, low cost, and innovative technology. This review give details about meter dose topical spray of Estradiol, 1% tolnaftate, 2% Miconazole nitrate spray, 0.5% w/w Voriconazole spray, Clotrimazole transdermal apray, Lopinavir meter dose transdermal spray are studied by researcher. This review also enlisted patents and marketed formulation on topical spray from year 2007 to 2020.

Superior Skin Penetration of Diclofenac from Dynapar QPS Plus as Compared to Diclofenac Aerosol Spray

“…Dynapar QPS Plus is non-pressurized spray dispensing system which does not require use of propellant so safer than aerosol spray pumps [16,17]. Dynapar QPS Plus container has metered valve for delivering exact quantities of product at each discharge.…”

“…The aerosol based spray pumps have also been developed with the aim of providing higher penetration. However these aerosol based spray pump are pressurized system which uses propellants which are not much user and environment friendly [16,17]. Further, non-metered topical spray aerosols are not able to deliver accurate dosing of drugs [18].…”

Formulation and Evaluation of Gambier (Uncaria gambir)-Chitosan Microparticle Intranasal Delivery for Alzheimer’s Diseases

“…This process was repeated ten times, and the average weight of the spray produced per spray (individual weights) was calculated. The difference between the weights generated in each experiment should not exceed 6% and should not exceed 10% of the average weight of ten trials (Pawar and Chaudhary, 2015) .…”

“…The weight at each spray in the solution is collectively determined by evaluating the uniformity of weight in a particular spray. Weighing were done at 6th, 7th, 8th, 82th, 164th, 165th, and 166th spray (Pawar and Chaudhary, 2015) .…”

Narrative Review: Herbal Nanospray Sebagai Anti-Aging

“…Sediaan spray dipilih karena teknologi spray dapat memberikan profil penghantaran yang cepat dan mudah kering sehingga memberikan pengalaman yang menyenangkan untuk pasien. Sediaan spray juga memiliki prinsip mengikuti kaidah sifat alir cairan Newton, dimana dengan sifat alir Newton menujukkan profil cairan mudah dikeluarkan dari wadah penyimpanan tanpa bantuan propellant [70,71]. Keuntungan pemberian topikal spray menurut Pawar et al (2017) [72], diantaranya: tidak perlu alat mekanis apapun untuk pengaplikasian, tanpa kontak langsung dengan jari, sediaan dapat diberikan langsung di tempat yang diinginkan, ringan saat dipakai dan area aplikasi yang relatif luas.…”