In heterogeneous dense networks where spectrum is shared, users privacy remains one of the major challenges. On a multi-antenna relay-assisted multi-carrier interference channel, each user shares the frequency and spatial resources with all other users. When the receivers are not only interested in their own signals but also in eavesdropping other users' signals, the cross talk on the frequency and spatial channels becomes information leakage. In this paper, we propose a novel secrecy rate enhancing relay strategy that utilizes both frequency and spatial resources, termed as information leakage neutralization. To this end, the relay matrix is chosen such that the effective channel from the transmitter to the colluding eavesdropper is equal to the negative of the effective channel over the relay to the colluding eavesdropper and thus the information leakage to zero. Interestingly, the optimal relay matrix in general is not block-diagonal which encourages users' encoding over the frequency channels. We proposed two information leakage neutralization strategies, namely efficient information leakage neutralization (EFFIN) and optimized information leakage neutralization (OPTIN). EFFIN provides a simple and efficient design of relay processing matrix and precoding matrices at the transmitters in the scenario of limited power and computational resources. OPTIN, despite its higher complexity, provides a better sum secrecy rate performance by Fig. 1. Three overlapping LTE cells. The sum secrecy rates over the cells can be improved if a smart multi-antenna relay is introduced into the system. The emphasized arrows from BS 1 to the smart relay in the middle and then to UE 1 illustrate that desired signal strength (together with the direct channel path in red) can be boosted by choosing an appropriate relay strategy. The emphasized arrows from BS 2 to the smart relay and then to UE 1 illustrate that information leakage (shown by a dashed arrow in blue) can be neutralized by choosing the relay strategy appropriately.optimizing the relay processing matrix and the precoding matrices jointly. The proposed methods are shown to improve the sum secrecy rates over several state-of-the-art baseline methods.