Non-selective impairment of Wisconsin Card Sorting Test performance in patients with schizophrenia

Dieci, M.; Vita, Antonio; Silenzi, Carlo; Caputo, Alberto; Comazzi, Margherita; Ferrari, Lara; Ghiringhelli, Laura; Mezzetti, Maura; Tenconi, F.; Invernizzi, G

doi:10.1016/s0920-9964(96)00125-9

Cited by 25 publications

(14 citation statements)

References 50 publications

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“…Articles reporting number of categories achieved and perseverative errors in SCZ, REL, and HC were included. Effect sizes were calculated and reported on a total of 41 articles (38 categories achieved: Altshuler et al, 2004; Battaglia et al, 1994; Braff et al, 1991; Cadenhead et al, 1999; Condray et al, 1999; Dieci et al, 1997; Drakeford et al, 2006; Egan, Goldberg et al, 2001; Franke et al, 1992; Glahn et al, 2000; Gold et al, 1997; Goldberg et al, 1998; Gooding et al, 1999; Gooding and Tallent, 2002; Gooding et al, 2001; Haut et al, 1996; Hoff et al, 1992; Hoff et al, 1998; Josman and Katz, 2006; Keefe et al, 1994; Keri et al, 2001; Laurent et al, 2000; Laurent et al, 2001; Merrin et al, 2006; Morrens et al, 2006; Perry and Braff, 1998; Rybakowski and Borkowska, 2002; Seidman et al, 1991; Shum et al, 2004; Snitz et al, 1999; Stratta et al, 2003; Stratta, Daneluzzo, Mattei et al, 1997; Stratta, Daneluzzo, Prosperini et al, 1997; Suhr, 1997; Sullivan et al, 1993; Tallent and Gooding, 1999; Toomey et al, 1998; Wolf et al, 2002; and 30 perseverative errors: Altshuler et al, 2004; Battaglia et al, 1994; Condray et al, 1999; Dieci et al, 1997; Drakeford et al, 2006; Egan, Goldberg et al, 2001; Glahn et al, 2000; Gold et al, 1997; Gooding et al, 1999; Gooding and Tallent, 2002; Gooding et al, 2001; Haut et al, 1996; Josman and Katz, 2006; Keefe et al, 1994; Keri et al, 2001; Laurent et al, 2000; Laurent et al, 2001; Merrin et al, 2006; Rybakowski and Borkowska, 2002; Scarone et al, 1993; Shum et al, 2004; Snitz et al, 1999; Stratta, Daneluzzo, Mattei et al, 1997; Stratta, Daneluzzo, Prosperini et al, 1997; Suhr, 1997; Sullivan et al, 1993; …”

Section: Neuropsychological Measuresmentioning

confidence: 99%

Endophenotypes in schizophrenia: A selective review

Allen

Griss

Folley

et al. 2009

Schizophrenia Research

185

113

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Background Given the wealth of data in the literature on schizophrenia endophenotypes, it is useful to have one source to reference their frequency data. We reviewed the literature on disease-liability associated variants in structural and functional magnetic resonance images (MRI), sensory processing measures, neuromotor abilities, neuropsychological measures, and physical characteristics in schizophrenia patients (SCZ), their first-degree relatives (REL), and healthy controls (HC). The purpose of this review was to provide a summary of the existing data on the most extensively published endophenotypes for schizophrenia. Methods We searched PubMed and MedLine for all studies on schizophrenia endophenotypes comparing SCZ to HC and/or REL to HC groups. Percent abnormal values, generally defined as > 2 SD from the mean (in the direction of abnormality) and/or associated effect sizes (Cohen’s d) were calculated foreach study. Results Combined, the articles reported an average 39.4% (SD=20.7%; range=2.2-100%) of abnormal values in SCZ, 28.1% (SD=16.6%; range=1.6-67.0%) abnormal values in REL, and 10.2% (SD=6.7%; range=0.0-34.6%) in HC groups. Conclusions These findings are reviewed in the context of emerging hypotheses on schizophrenia endophenotypes, as well as a discussion of clustering trends among the various intermediate phenotypes. In addition, programs for future research are discussed, as instantiated in a few recent large-scale studies on multiple endophenotypes across patients, relatives, and healthy controls.

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Section: Neuropsychological Measuresmentioning

confidence: 99%

Endophenotypes in schizophrenia: A selective review

Allen

Griss

Folley

et al. 2009

Schizophrenia Research

185

113

View full text Add to dashboard Cite

show abstract

“…Similarly, Goldstein et al 38 found that dense perseverative behavior is not common to all patients with schizophrenia. Comparing the discriminative power of the WCST and the WAIS, Dieci et al 17 demonstrated a lack of selectivity of the WCST performance in identifying individuals with schizophrenia from healthy comparison subjects.…”

Section: Discussionmentioning

confidence: 99%

“…[17][18][19] One reason for the controversial findings is the lack of a strict definition of these functions and the fact that none of the available neuropsy-ATBASOGLU et al…”

mentioning

confidence: 99%

Relative Sparing of Executive Functions in the Early Phase of Schizophrenia

Atbaşoğlu¹,

Özgüven²,

Saka³

et al. 2005

JNP

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Findings about the impairment of executive functions in schizophrenia are not conclusive. The authors hypothesized that the severity of the impairments in the abilities that comprise EF might be different. Forty patients were assessed with a comprehensive battery that included four measures of executive functions and were compared with 60 healthy subjects. Set shifting and response inhibition showed no significant between-group differences. Mental flexibility and concept formation were significantly worse in patients, but the effect sizes were small. Some executive functions might be relatively spared, at least in the early phase of schizophrenia. Studies on individual executive functions may yield more replicable findings.

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“…In addition to findings of specific deficits in attention, working memory and executive function (Shallice et al 1991 ;McGrath et al 1997 ;Seaton et al 2001), many studies highlight a general impairment in intellectual functioning (Pollack et al 1968 ;Dieci et al 1997 ;Bilder et al 2006 ;Woodberry et al 2008 ;Urfer-Parnas et al 2010b). The extent of this impairment was originally thought to be a powerful predictor of subsequent functioning, even more so than current symptom levels (Velligan et al 1997(Velligan et al , 2000Harvey et al 1998 ;Green et al 2000).…”

Section: Introductionmentioning

confidence: 98%

Intellectual functioning and the long-term course of schizophrenia-spectrum illness

et al. 2010

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These largely negative findings are discussed in the light of strong predictive relationships existing between genetic risk, diagnosis and functional outcomes. The pattern of predictive relationships suggests that overall cognitive functioning may play less of a role in schizophrenia-spectrum pathology than is widely believed, at least among populations with an evident family history of schizophrenia.

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Non-selective impairment of Wisconsin Card Sorting Test performance in patients with schizophrenia

Cited by 25 publications

References 50 publications

Endophenotypes in schizophrenia: A selective review

Endophenotypes in schizophrenia: A selective review

Relative Sparing of Executive Functions in the Early Phase of Schizophrenia

Intellectual functioning and the long-term course of schizophrenia-spectrum illness

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