Non-small cell lung cancer and silent brain metastasis

Cos, Julio Sánchez de; González, M. Agustín Sojo; Montero, María Victoria; Calvo, María Cristina Pérez; Vicente, María Jesús Martín; Valle, Manuel Hernández

doi:10.1016/j.lungcan.2008.04.013

Cited by 102 publications

(64 citation statements)

References 18 publications

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“…The majority of NSCLC patients are diagnosed at an advanced stage, presenting with metastatically or locally advanced disease, leading to ~90% of lung cancer patients succumbing to metastasis (3). The metastasis progression of NSCLC involves multi-step genetic events, and the molecular underlying mechanisms have not been documented to date (4).…”

Section: Introductionmentioning

confidence: 99%

miR-154 inhibits migration and invasion of human non-small cell lung cancer by targeting ZEB2

et al. 2016

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Abstract. Emerging evidence suggests that microRNAs (miRs) play critical roles in the development and progression of non-small cell lung cancer (NSCLC). In a previous study, the present authors demonstrated that miR-154 acts as a tumor suppressor in NSCLC; however, its underlying molecular mechanism and target in NSCLC remain poorly understood. In the present study, ectopic expression of miR-154 remarkably suppressed cell migration and invasion in NSCLC cells.Zinc finger E-box binding homeobox 2 (ZEB2) was identified as a direct target of miR-154 in NSCLC cells. Furthermore, overexpression of miR-154 could decrease the expression of ZEB2 at the messenger RNA and protein levels. Ectopic expression of miR-154 also increased the levels of E-cadherin, an epithelial marker, and decreased the levels of vimentin, a mesenchymal marker, which contributed to suppress epithelial-mesenchymal transition (EMT) and to inhibit cell migration and invasion. In addition, downregulation of ZEB2 exerted similar effects to those caused by miR-154 overexpression on NSCLC cell migration and invasion, while upregulation of ZEB2 could significantly reverse the inhibitory effects on migration and invasion caused by miR-154 on NSCLC cells. These findings demonstrated that miR-154 inhibited migration and invasion of NSCLC cells by regulating EMT through targeting ZEB2, suggesting that miR-154 may be a potential anticancer therapeutic target for NSCLC.

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Section: Introductionmentioning

confidence: 99%

miR-154 inhibits migration and invasion of human non-small cell lung cancer by targeting ZEB2

et al. 2016

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“…First, brain and bone metastases were not unfavorable prognostic factors in our study; however, several previous studies reported brain metastasis to be one of the unfavorable prognostic factors, as neurological symptoms due to metastasis may be irreversible (4,13,14). Bone metastasis has also been considered to be associated with poor survival due to skeletal-related events, such as pathological fractures, spinal cord compression and hypercalcemia of malignancy (15).…”

Section: Median Os (Months) -----------------------------------------mentioning

confidence: 49%

Specific organ metastases and survival in metastatic non-small-cell lung cancer

Tamura

Kurishima

Nakazawa

et al. 2014

Molecular and Clinical Oncology

278

193

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Abstract. The present retrospective study was performed to evaluate the clinicopathological characteristics associated with distant metastasis from non-small-cell lung cancer (NSCLC). The records of NSCLC patients with metastasis at the time of diagnosis between 1999 and 2012 were reviewed. Of the consecutive 1,542 NSCLC patients diagnosed during the study period, 729 (47.3%) patients presented with distant metastasis. Among those 729 metastatic NSCLC patients, 250 (34.3%), 234 (32.1%), 207 (28.4%), 122 (16.7%), 98 (13.4%) and 69 (9.5%) had bone, lung, brain, adrenal gland, liver and extrathoracic lymph node metastasis, respectively. In a multivariate analysis using the Cox proportional hazards model, liver and adrenal gland metastases were unfavorable prognostic factors. However, brain and bone metastases were not statistically significant prognostic factors. Using a logistic regression analysis, metastasis to the adrenal glands and the presence of pleural and̸or pericardial fluid effusion were correlated with a poor performance status. Therefore, when planning the treatment of NSCLC patients, particularly those with liver and adrenal gland metastases, we should take into consideration information regarding these unfavorable organ metastases.

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“…According to pathological pattern, non-small-cell lung cancer (NSCLC) is mainly divided into squamous cell carcinoma (SCC) and adenocarcinoma (AC) [1]. The rate of 5-year survival was very low (approximately 10-15%) [2]. Metastasis, which is characterized by the ability of cancer cells to invade into adjacent area, extravagate into blood or lymphatic vessels, and extravagate into a distant environment, is required for prognosis of patients with aggressive NSCLC [3].…”

Section: Introductionmentioning

confidence: 99%

Downregulation of miR‐638 promotes invasion and proliferation by regulating SOX2 and induces EMT in NSCLC

Xia

Liu

et al. 2014

FEBS Letters

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Edited by Tamas DalmayKeywords: miR-638 SRY (sex determining region Y)-box 2 Proliferation Invasion Epithelial-to-mesenchymal transition Non-small-cell lung cancer a b s t r a c t Aberrant expression of microRNAs has been shown to regulate the biological processes of lung cancer cells. However, the role of miR-638 in the development of NSCLC is still unclear. In this study, low miR-638 and high SOX2 were shown to be associated with tumor size and metastasis of NSCLC patients. Downregulated miR-638 could promote cell invasion and proliferation, while high miR-638 expression reversed the effect. Furthermore, miR-638 could regulate SOX2 by directly binding to its 3 0 -UTR. Silencing of SOX2 by siRNA partially abolished the enhancement of cell invasion and proliferation induced by downregulated miR-638. Aberrant miR-638 expression could modulate the expression levels of markers of epithelial-to-mesenchymal transition. Our results indicate that miR-638 may play a pivotal role in the development of NSCLC.

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Non-small cell lung cancer and silent brain metastasis

Cited by 102 publications

References 18 publications

miR-154 inhibits migration and invasion of human non-small cell lung cancer by targeting ZEB2

miR-154 inhibits migration and invasion of human non-small cell lung cancer by targeting ZEB2

Specific organ metastases and survival in metastatic non-small-cell lung cancer

Downregulation of miR‐638 promotes invasion and proliferation by regulating SOX2 and induces EMT in NSCLC

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