Non-small-cell lung cancer metastasis to the oral cavity: A case report

Abstract

Abstract. We herein report an unusual occurrence of lung cancer metastasis to the oral cavity, reflecting the progression of the primary malignancy. A biopsy of oral lesions should always be performed, even of those located in uncommon sites, in patients with a history of uncontrolled lung cancer. Although this is a rare occurrence, our patient exhibited characteristics suggestive of oral metastasis from lung cancer, namely presence of lung adenocarcinoma, development of oral metastasis during the clinical course of the disease, accompanying multiple metastatic lesions, including to the brain and abdomen, and rapid fatal progression after the manifestation of oral metastasis. It is important to acknowledge the possibility of metastasis to the oral cavity in lung cancer patients with extensive metastases. Prompt diagnosis by biopsy of the lesion is required to establish the correct diagnosis.

Two rare cases of oral metastasis arising from lung adenocarcinoma and esophageal carcinoma

“…In the literature, there are more cases of metastasis to the jawbones than to oral soft tissues ( 1 , 10 ). However, as in the majority of the cases both the bone and the mucosa are affected, the first metastatic site may not always be apparent ( 11 ). The clinical presentation of oral metastasis may vary from local swelling or pain to paresthesia and numbness ( 2 , 11 ).…”

“…However, as in the majority of the cases both the bone and the mucosa are affected, the first metastatic site may not always be apparent ( 11 ). The clinical presentation of oral metastasis may vary from local swelling or pain to paresthesia and numbness ( 2 , 11 ). Here we describe two cases of metastasis to the oral soft tissue (cavity) originating from the lung and esophagus presenting advanced stage and evolution to death within one month after the diagnosis of metastasis in the mouth.…”

“…Lung cancer, one of the most prevalent conditions in the world, is the most frequent cause of cancer-related death worldwide, and smoking is the predominant risk factor ( 11 - 13 ). Moreover, the lung is the most common source for metastasis to the oral soft tissues in men, and the attached gingiva is the most common affected site followed by the tongue ( 1 , 6 , 8 ).…”

Histopathological analysis of metastatic tumours of the oral cavity with example of metastatic renal cell carcinoma to tongue

“…Carcinoma of bile ducts is positive for cytokeratin 19. The urothelial carcinoma is positive for Urothelin and WT1, while hepatocellular liver carcinoma is positive for Hep Par 1 3,4,6,8,13 .…”

“…Malignant tumours of the lung, breast, kidney, liver, bone, prostate, thyroid gland, skin, colon and female genital organs most commonly give metastases in oral region. The incidence of metastatic tumours of oral region is rising, according to the fact that patients with cancers live longer due to advances in cancer diagnosis and management 2,[4][5][6] .…”