Non‐specific Ulcerative Colitis in Chinese and Indians in Singapore

Fung, Wye-Poh; Monteiro, Estela; Murugasu, J. J.; Ng, KwokeiJ.; Kho, K. M.; Lee, S. K.

doi:10.5694/j.1326-5377.1971.tb50597.x

Cited by 11 publications

(11 citation statements)

References 18 publications

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“… 1-150 References7 81 94-96 99 101-108 110 113-117 120-122 124 127 128 132 133 135-138 140 142 143 145 148 150 155 157 159 161 163 165 167 170-173 176 177 180–182 185–189 191–205 1-151 References93 98 100 109 112 123 126 134 141 146 147 149 151-154 158 160 162 166 168 169 175 ‡ References10 97 111 118 119 125 129-131 139 144 156 164 174 178 179 183 184 190 …”

Section: Resultsmentioning

confidence: 99%

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The risk of colorectal cancer in ulcerative colitis: a meta-analysis

Eaden

Abrams

Mayberry

2001

Gut

2,594

1,706

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Background and aims-Controversy surrounds the risk of colorectal cancer (CRC) in ulcerative colitis (UC). Many studies have investigated this risk and reported widely varying rates. Methods-A literature search using Medline with the explosion of references identified 194 studies. Of these, 116 met our inclusion criteria from which the number of patients and cancers detected could be extracted. Overall pooled estimates, with 95% confidence intervals (CI), of cancer prevalence and incidence were obtained using a random eVects model on either the log odds or log incidence scale, as appropriate. Results-The overall prevalence of CRC in any UC patient, based on 116 studies, was estimated to be 3.7% (95% CI 3.2-4.2%). Of the 116 studies, 41 reported colitis duration. From these the overall incidence rate was 3/1000 person years duration (pyd), (95% CI 2/1000 to 4/1000). The overall incidence rate for any child was 6/1000 pyd (95% CI 3/1000 to 13/1000). Of the 41 studies, 19 reported results stratified into 10 year intervals of disease duration. For the first 10 years the incidence rate was 2/1000 pyd (95% CI 1/1000 to 2/1000), for the second decade the incidence rate was estimated to be 7/1000 pyd (95% CI 4/1000 to 12/1000), and in the third decade the incidence rate was 12/1000 pyd (95% CI 7/1000 to 19/1000). These incidence rates corresponded to cumulative probabilities of 2% by 10 years, 8% by 20 years, and 18% by 30 years. The worldwide cancer incidence rates varied geographically, being 5/1000 pyd in the USA, 4/1000 pyd in the UK, and 2/1000 pyd in Scandinavia and other countries. Over time the cancer risk has increased since 1955 but this finding was not significant (p=0.8). Conclusions-Using new meta-analysis techniques we determined the risk of CRC in UC by decade of disease and defined the risk in pancolitics and children. We found a non-significant increase in risk over time and estimated how risk varies with geography. (Gut 2001;48:526-535)

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Section: Resultsmentioning

confidence: 99%

“…1-150 References7 81 94-96 99 101-108 110 113-117 120-122 124 127 128 132 133 135-138 140 142 143 145 148 150 155 157 159 161 163 165 167 170-173 176 177 180–182 185–189 191–205 …”

Section: Resultsmentioning

confidence: 99%

The risk of colorectal cancer in ulcerative colitis: a meta-analysis

Eaden

Abrams

Mayberry

2001

Gut

2,594

1,706

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“…The highest incidence of IBD is in Western countries such as North America, Northern Europe, and Australia, with CD incidence ranging from 10.6 to 29.3 per 100,000 person-years and UC incidence ranging from 17.4 to 24.3 per 100,000 person-years in 1998–2010 [3]. In comparison, population-based incidence data were not available in Asia until the 1970s, reflecting an “emerging” disease pattern in Asia [4, 5]. In Singapore [4, 5], Hong Kong [6], Japan [7], and South Korea [8], where population-based statistics are available, the CD incidence rates per 100,000 person-years have increased from 0.04–0.6 in 1970–1992 to 1.0–1.3 in 1998–2006, and UC incidence rate increased from 0.1–2.0 in 1970–1990 to 3.1 in 2001–2005.…”

Section: Introductionmentioning

confidence: 99%

Smoking and Inflammatory Bowel Disease: A Comparison of China, India, and the USA

Wang

Ghadermarzi

et al. 2018

Dig Dis Sci

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“…IBD has previously been considered to be uncommon amongst Asians. Fung and Khoo reported in 1969 on two patients with non‐specific UC 3 and Goh et al. in 1980 reported on12 patients with CD over a 10‐year period and termed this an ‘uncommon disease in the tropics’ 4 .…”

Section: Introductionmentioning

confidence: 99%

Inflammatory bowel disease: A survey of the epidemiology in Asia

Goh¹,

Xiao²

2009

J of Digest Diseases

113

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Inflammatory bowel disease (IBD) has long been considered a disease that affects predominantly a Western population. The incidence and prevalence rates from Asian populations are much lower in comparison. More recent data, however, have shown significantly higher rates in Asians and time trend studies have shown an increase in the incidence of ulcerative colitis (UC) and a similar but lower rise in Crohn's disease (CD). The epidemiological changes that are taking place mirror that of the Western experience seen 50 years previously and seem to occur in parallel with the rapid socioeconomic development taking place in Asia. It appears that certain racial groups are more prone than others to develop IBD. For instance, Indians in South‐East Asia have higher rates compared to Chinese and Malays. While there is host genetic predisposition, environmental factor(s) may be responsible for this difference. Migrant studies of South Asians in the UK, where second‐generation immigrants have assumed incidence rates as high as the indigenous whites and Asian Jews who develop high incidence rates comparable to Jews from Europe or North America in Israel point to the role of environmental factors. It is unclear which specific factors are responsible. Studies have suggested a change in diet to a more Westernized one may underlie this epidemiological change in the Asian population. It is likely that there are racial groups amongst Asians who are more susceptible to IBD and who will demonstrate a higher frequency of IBD when exposed to putative environmental factors.

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Non‐specific Ulcerative Colitis in Chinese and Indians in Singapore

Cited by 11 publications

References 18 publications

The risk of colorectal cancer in ulcerative colitis: a meta-analysis

The risk of colorectal cancer in ulcerative colitis: a meta-analysis

Smoking and Inflammatory Bowel Disease: A Comparison of China, India, and the USA

Inflammatory bowel disease: A survey of the epidemiology in Asia

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