Non-specific vaginitis: its diagnosis and treatment

Teare, E.L.; Bakhtiar, M.; Rogers, Thomas R.; Oates, Jennifer

doi:10.1093/jac/8.6.496

Cited by 2 publications

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“…They may lack the anaerobic synergent and thus remain free of the symptoms. As it is recognized that a large number of women who are colonized with G. vaginalis do not have vaginitis, it has also been known that certain percentage of patients with symptoms and signs consistent with NSV do not yield G. vaginalis in culture (10,13,19,20). As studies continue to elucidate the etiology and pathogenesis of NSV which now appears to be a polymicrobial infection, G. vaginalis may best serve as an indicator organism for the laboratory determination of NSV in the majority of women with this syndrome.…”

Section: Resultsmentioning

confidence: 99%

“…Gardnerella vaginalis has been implicated as the etiological agent of nonspecific vaginitis (NSV) in numerous studies (1,11,13,15,19,20) foliowing the initial report by Gardner and Dukes (6). However, the significance of the isolation of this organism from the lower genital tract has been controversial because asymptomatic women are frequently found to have positive cultures for G. vaginalis (5,12,14).…”

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confidence: 99%

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Semiquantitative culture of Gardnerella vaginalis in laboratory determination of nonspecific vaginitis

Ratnam¹,

Fitzgerald²

1983

J Clin Microbiol

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To evaluate the usefulness of quantitative cultures of Gardnerella vaginalis in the laboratory determination of nonspecific vaginitis, the actual and relative numbers of G. vaginalis in genital cultures of a general patient population were assessed semiquantitatively, and the laboratory results were then correlated with the clinical findings. Of the 1,585 women studied, 417 (26.3%) yielded G. vaginalis in culture. Of these, only 113 (27.1%) were found to have symptoms and signs consistent with nonspecific vaginitis. G. vaginalis was obtained in pure or predominant growth from 87 of 100 consecutive cases with nonspecific vaginitis and 32 of 100 consecutive cases without the symptoms or signs of vaginitis (P less than 0.001). Hence, the positive predictive value of isolation of G. vaginalis in pure and predominant growths was determined to be 73% (87 of 119). Conversely, G. vaginalis was isolated in mixed or light growth significantly more often from asymptomatic women than from symptomatic patients, i.e., 68 versus 13 cases. Therefore, the negative predictive value of isolation of G. vaginalis in mixed and light growths was found to be 84% (68 of 81). Quantitation of the relative amount of G. vaginalis growth had higher predictive values as compared with the assessment of G. vaginalis growth alone. We conclude that quantitative culture of G. vaginalis is essential to obtain maximum reliability of culture results in the laboratory determination of nonspecific vaginitis. Although quantitated cultures of G. vaginalis have high predictive values, laboratory results must be interpreted in conjunction with the clinical findings.

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Section: Resultsmentioning

confidence: 99%