Non‐steroidal anti‐inflammatory drugs and the risk of head and neck cancer: A case‐control analysis

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) and acetylsalicylic acid (aspirin) have been associated with a reduced risk for certain cancers. We explored the association between use of NSAIDs and the risk of head and neck cancer (HNC). We conducted a case-control analysis in the UK-based Clinical Practice Research Datalink (CPRD) among people below the age of 90 years with incident HNC between 1995 and 2013. Six controls per case were matched on age, sex, calendar time, general practice, and number of years of active history in the CPRD prior to the HNC diagnosis. Other potential confounders including comorbidities and comedication were also evaluated, and we adjusted our final analyses for BMI, smoking and alcohol consumption. Our analyses included 2,745 HNC cases and 16,470 controls. Aspirin or NSAID use overall did not significantly change the HNC risk. However, patients with six or more prescriptions for ibuprofen were at a statistically significantly reduced risk for HNC (adjusted OR 0.59, 95% CI 0.37-0.94). The HNC risk tended to decrease with increasing cumulative exposure to ibuprofen, and to be more pronounced for cancer of the larynx. To conclude, in this large population-based observational study we found a decreased risk for HNC associated with regular use of ibuprofen.

Infrequent tooth brushing and teeth lost may increase the risk of oral and pharyngeal cancers: A nationwide population-based cohort study in Korea.

“…NSAID is a group of drugs commonly prescribed during the treatment of periodontal disease. Though the results are not consistent, the potential chemo-preventive effect of NSAIDs for oral and pharyngeal cancer had been studied and suggested recently [36][37][38][39].…”

Use of nonaspirin nonsteroidal anti‐inflammatory drugs and risk of head and neck cancer: A nationwide case–control study

“…Our finding of decreased risk estimates among long‐term consistent nonaspirin NSAID users supports previous studies reporting reduced HNC risk in ibuprofen users, who take the medication daily or had ≥6 prescriptions issued . Similar to our results, these studies found no association between HNC risk and ever‐use of nonaspirin NSAIDs.…”

“…The literature assessing risk of HNC in relation to use of NSAIDs has primarily focused on aspirin use and reported equivocal results. Only few observational studies have examined the association between nonaspirin NSAID use and risk of HNC and the results are inconsistent . Limitations of these studies include small sample sizes, self‐reported exposure information and lack of both information on potential confounders as well as thorough assessments of patterns of use (dose–response relationships).…”

“…Only few observational studies have examined the association between nonaspirin NSAID use and risk of HNC and the results are inconsistent. [11][12][13][14][15][16] Limitations of these studies include small sample sizes, self-reported exposure information and lack of both information on potential confounders as well as thorough assessments of patterns of use (dose-response relationships). In Denmark, the prevalence of HPV in oropharyngeal cancer is high and the incidence of HPV-associated oropharyngeal cancer is increasing.…”

Antitumoral effects of γCdcPLI, a PLA2 inhibitor from Crotalus durissus collilineatus via PI3K/Akt pathway on MDA-MB-231 breast cancer cell

“…Many chemical or natural inhibitors of the PLA 2 pathway show antitumor effects and may be potential anti-cancer drugs 19 – 24 . Some non-steroidal anti-inflammatory drugs that inhibit the prostaglandin pathway (COX-2), such as Ibuprofen, have been described as potentially reducing the risk of cancer 24 , 25 .…”