Current long-term use of calcium channel blockers was associated with a significantly reduced risk of a Parkinson disease diagnosis, while the risk was not materially altered for users of angiotensin converting enzyme inhibitors or beta-blockers and, with less statistical precision, for users of angiotensin II antagonists.

Whereas some researchers have argued that perfectionism in sports is maladaptive because it is related to dysfunctional characteristics such as higher competitive anxiety, the present article argues that striving for perfection is not maladaptive and is unrelated to competitive anxiety. Four samples of athletes (high school athletes, female soccer players, and two samples of university student athletes) completed measures of perfectionism during competitions and competitive anxiety. Across samples, results show that overall perfectionism was associated with higher cognitive and somatic competitive anxiety. However, when striving for perfection and negative reactions to imperfection were differentiated, only the latter were associated with higher anxiety, whereas striving for perfection was unrelated to anxiety. Moreover, once the influence of negative reactions to imperfection was partialled out, striving for perfection was associated with lower anxiety and higher self-confidence. The present findings suggest that striving for perfection in sports is not maladaptive. On the contrary, athletes who strive for perfection and successfully control their negative reactions to imperfection may even experience less anxiety and more self-confidence during competitions.

No abstract

This study aims at answering two basic questions regarding the mechanisms with which hormones modulate functional cerebral asymmetries. Which steroids or gonadotropins fluctuating during the menstrual cycle affect perceptual asymmetries? Can these effects be demonstrated in a cross-sectional (follicular and midluteal cycle phases analyzed) and a longitudinal design, in which the continuous hormone and asymmetry fluctuations were measured over a time course of 6 weeks? To answer these questions, 12 spontaneously cycling right-handed women participated in an experiment in which their levels of progesterone, estradiol, testosterone, LH, and FSH were assessed every 3 days by blood-sample based radioimmunoassays (RIAs). At the same points in time their asymmetries were analyzed with visual half-field (VHF) techniques using a lexical decision, a figure recognition, and a face discrimination task. Both cross-sectional and longitudinal analyzes showed that an increase of progesterone is related to a reduction in asymmetries in a figure recognition task by increasing the performance of the left-hemisphere which is less specialized for this task. Cross-sectionally, estradiol was shown to have significant relationships to the accuracy and the response speed of both hemispheres. However, since these effects were in the same direction, asymmetry was not affected. This was not the case in the longitudinal design, where estradiol affected the asymmetry in the lexical decision and the figural comparison task. Overall, these data show that hormonal fluctuations within the menstrual cycle have important impacts on functional cerebral asymmetries. The effect of progesterone was highly reliable and could be shown in both analysis schemes. By contrast, estradiol mainly, but not exclusively, affected both hemispheres in the same direction.

Use of metformin was associated with a decreased risk of pancreatic cancer in women only, whereas use of sulfonylureas and of insulin was associated with an increased risk of pancreatic cancer.