Non‐suppurative Hepatitis: A Study of Acute and Chronic Forms With Special Reference to Biochemical and Histological Changes

Ij, Wood; We, King

doi:10.5694/j.1326-5377.1948.tb97104.x

Cited by 32 publications

(3 citation statements)

References 40 publications

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“…One of the earliest publications to describe what we now know as AIH, reported it as a persistent, relapsing jaundice with a preponderance in young females, less than 30 years of age, and raised serum globulins [5]. It was recognized as an 'anomaly of immune tolerance', with viral hepatitis as a trigger.…”

Section: Early Descriptionsmentioning

confidence: 99%

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Autoimmune Hepatitis: From Evolution to Current Status—A Pathologist’s Perspective

Sakhuja,

Goyal

2024

Diagnostics

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Autoimmune hepatitis (AIH) is a chronic, relapsing and remitting, immune-mediated liver disease that progresses to cirrhosis if left untreated. A significant number of patients may present with acute hepatitis or acute liver failure, which are often misdiagnosed as toxic liver injury. AIH shows a preponderance in young women but may be seen in children and the elderly. Diagnosis requires the integration of clinical, biochemical, and serologic parameters, along with supportive liver histology and exclusion of other causes of liver disease. Liver biopsy is a prerequisite for diagnosis of AIH, to assess severity and stage of disease, exclude other entities, and recognize any concurrent morbidities. No single biomarker or histologic feature is pathognomonic for AIH. The diagnostic and histologic criteria have undergone several modifications since the original scoring system was proposed by the International Autoimmune Hepatitis Group (IAIHG) in 1993. Recently, the IAIHG has proposed consensus recommendations for histologic criteria, relevant for both acute and chronic AIH. This review article will describe the evolving diagnostic criteria for AIH, with their limitations and utility, and with an emphasis on the role of liver histology in the diagnosis and management of AIH.

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Section: Early Descriptionsmentioning

confidence: 99%

“…of age, and raised serum globulins [5]. It was recognized as an 'anomaly of immune tolerance', with viral hepatitis as a trigger.…”

Section: Portal Inflammationmentioning

confidence: 99%

Autoimmune Hepatitis: From Evolution to Current Status—A Pathologist’s Perspective

Sakhuja,

Goyal

2024

Diagnostics

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“…He joined the Clinical Research Unit (CRU) of the Royal Melbourne Hospital and the WEHI headed by Ian Wood. Macfarlane Burnet, Director of the Institute, had switched interests to immunology and Ian Wood had assembled many cases of chronic hepatitis studied by himself, King, Saint and Joske and Ian Mackay 1–3 . Mackay entered a collaboration with a visiting scientist DC Gajdusek who was developing a serological test for hepatitis virus infection 4 .…”

Section: The Early Era and Autoimmune Liver Diseasementioning

confidence: 99%

Overview: Liver disease and transplantation

Powell

2009

J of Gastro and Hepatol

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Australia has had a proud and enviable record of seminal contributions to hepatology, with many contributors. Thus, any attempt to summarize these contributions ab initio in a brief review article is a significant challenge, primarily because it is so easy to overlook or underestimate particular aspects. In this article, I have confined my comments primarily to the areas where the contributions have had a significant global impact and have clearly been recognized internationally. This means that many worthwhile Australian additions will be omitted if there was less apparent international impact. The first significant interest in liver disease in Australia was from the Melbourne group at the Walter and Eliza Hall Institute (WEHI) and Royal Melbourne Hospital, leading to seminal contributions to the description, diagnosis, aetiopathogenesis and therapy of autoimmune hepatitis and primary biliary cirrhosis. Others from Royal Prince Alfred Hospital in Sydney contributed substantially to the effects of immunosuppression of autoimmune hepatitis and to early descriptions of primary sclerosing cholangitis. Other areas where Australians have contributed significantly include steatohepatitis, iron metabolism (and in particular hemochromatosis), viral hepatitis (both at the molecular and clinical level), portal hypertension, and transplant immunology. The remarkable contribution of Professor Dame Sheila Sherlock to Australian hepatology is also summarized.

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Macroglobulins in Chronic Pancreatitis and Liver Cirrhosis

Svartz¹

1967

JAMA

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Non‐suppurative Hepatitis: A Study of Acute and Chronic Forms With Special Reference to Biochemical and Histological Changes

Cited by 32 publications

References 40 publications

Autoimmune Hepatitis: From Evolution to Current Status—A Pathologist’s Perspective

Autoimmune Hepatitis: From Evolution to Current Status—A Pathologist’s Perspective

Overview: Liver disease and transplantation

Macroglobulins in Chronic Pancreatitis and Liver Cirrhosis

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