Non-surgical therapies for peripheral nerve injury

Albornoz, Pilar Martínez de; Delgado, Pedro J.; Forriol, Francisco; Maffulli, Nicola

doi:10.1093/bmb/ldr005

Cited by 75 publications

(43 citation statements)

References 97 publications

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“…When injured, the nerve can lose its function, causing motor or sensitive deficits. There is retrograde axonal degeneration to the area of the lesion, so regeneration occurs slowly and sometimes incompletely [18,19]. …”

Section: Introductionmentioning

confidence: 99%

Photobiomodulation Therapy (PBMT) in Peripheral Nerve Regeneration: A Systematic Review

et al. 2018

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Photobiomodulation therapy (PBMT) has been investigated because of its intimate relationship with tissue recovery processes, such as on peripheral nerve damage. Based on the wide range of benefits that the PBMT has shown and its clinical relevance, the aim of this research was to carry out a systematic review of the last 10 years, ascertaining the influence of the PBMT in the regeneration of injured peripheral nerves. The search was performed in the PubMed/MEDLINE database with the combination of the keywords: low-level laser therapy AND nerve regeneration. Initially, 54 articles were obtained, 26 articles of which were chosen for the study according to the inclusion criteria. In the qualitative aspect, it was observed that PBMT was able to accelerate the process of nerve regeneration, presenting an increase in the number of myelinated fibers and a better lamellar organization of myelin sheath, besides improvement of electrophysiological function, immunoreactivity, high functionality rate, decrease of inflammation, pain, and the facilitation of neural regeneration, release of growth factors, increase of vascular network and collagen. It was concluded that PBMT has beneficial effects on the recovery of nerve lesions, especially when related to a faster regeneration and functional improvement, despite the variety of parameters.

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Section: Introductionmentioning

confidence: 99%

Photobiomodulation Therapy (PBMT) in Peripheral Nerve Regeneration: A Systematic Review

et al. 2018

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“…Therefore, the nerve can be injured by neuropraxia, axonotmosis or neurotmesis, the latter being more severe, which can lead to motor, sensory and functional losses, significantly interfering with the individual's daily, employment, social and emotional activities [1][2][3]. The incidence rate in the population compared to those of peripheral nerve damage is about 2% to 2.8%, reaching 5% when involving nerve plexuses and root nerves [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Low-Level Laser Therapy (LLLT) Improves the Repair Process of Peripheral Nerve Injuries: A Mini Review

Rosso¹,

Buchaim²,

Rosa³

et al. 2017

Int J Neurorehabilitation Eng

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Purpose: The aim of this study was to perform a mini-review on the effects of low-level laser therapy on nerve regeneration. Methods:In this study, the authors associated the new fibrin sealant derived from snake venom as a method of nerve repair end-to-side. Results and conclusion:The use of fibrin sealant effectively provided an axonal regeneration, and the association with low-level laser therapy elevated this regenerative process, as demonstrated in the morphometric and morphological analyzes.

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“…Peripheral nerve injuries have a major impact on patients and their ability to perform daily activities including returning to work; this creates social and economic concerns (de Albornoz et al, 2011; Faroni et al, 2015). One of the experimental models used to study this type of injury is sciatic nerve compression in rats, which is the most common compressive neuropathy of the lower limb, has easy surgical access and its ramifications are well characterised (Craig, 2013; Savastano et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

The morphological and functional effects of exercise in the aquatic environment, performed before and/or after sciatic nerve compression in Wistar rats

Kakihata¹,

Malanotte²,

Karvat³

et al. 2016

J Exerc Rehabil

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The aim of this study was to evaluate the effects of exercise in the aquatic environment, performed before and/or after sciatic nerve compression in Wistar rats on morphological and functional parameters. Twenty-five Wistar rats were divided into the following groups: control (C), lesion (L), trained+lesion (TL), lesion+exercise (LE), and training+lesion+exercise (TLE), who underwent right sciatic nerve compression on day 21 of the experiment. The TL and TLE groups were submitted to a jumping exercise in a water environment for 20 days prior to injury and the LE and TLE groups after injury. The functional analysis was carried out using the sciatic functional index (SFI). On the last day of the experiment, the right sciatic nerves were collected, processed and analysed according to morphology and morphometry. The C group showed higher SFI in relation to the other groups. In the morphometric analysis, in comparison to C, all groups showed a decrease in the diameter of the injured nerve fibre, the myelin sheath and an increase in the percentage of connective tissue. There was a decrease in axon diameter in L, TL, and LE groups and a decrease in the density of nerve fibres in the TL and LE groups. The exercise did not affect functional recovery. However, the exercise prior to the injury improved morphology of the nervous tissue, and when performed pre- and postinjury, there was also an improvement in nerve regeneration, but this was not the case with exercise performed after the injury demonstrating worse results.

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Non-surgical therapies for peripheral nerve injury

Abstract: The hypotheses proved in animals and in vitro should be translated to human clinical practice.

Cited by 75 publications

References 97 publications

Photobiomodulation Therapy (PBMT) in Peripheral Nerve Regeneration: A Systematic Review

Photobiomodulation Therapy (PBMT) in Peripheral Nerve Regeneration: A Systematic Review

Low-Level Laser Therapy (LLLT) Improves the Repair Process of Peripheral Nerve Injuries: A Mini Review

The morphological and functional effects of exercise in the aquatic environment, performed before and/or after sciatic nerve compression in Wistar rats

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